Cytotoxic effect of nanocrystalline MgFe2O4 particles for cancer cure
Nanocrystalline magnesium ferrites (MgFe2O4) were produced with an average grain size of about 20 nm. Their structural, morphological, and magnetic characterizations were studied. The cytotoxic effects of MgFe2O4 nanoparticles in various concentrations (25, 50, 100, 200, 400, and 800 μg/mL) against...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Hindawi Publishing Corporation
2013
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/52210/ http://psasir.upm.edu.my/id/eprint/52210/1/52210.pdf |
| _version_ | 1848852043769315328 |
|---|---|
| author | Kanagesan, Samikannu Hashim, Mansor Subramani, Tamilselvan Mohammed Alitheen, Noorjahan Banu Ismail, Ismayadi Bahmanrokh, Ghazaleh |
| author_facet | Kanagesan, Samikannu Hashim, Mansor Subramani, Tamilselvan Mohammed Alitheen, Noorjahan Banu Ismail, Ismayadi Bahmanrokh, Ghazaleh |
| author_sort | Kanagesan, Samikannu |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Nanocrystalline magnesium ferrites (MgFe2O4) were produced with an average grain size of about 20 nm. Their structural, morphological, and magnetic characterizations were studied. The cytotoxic effects of MgFe2O4 nanoparticles in various concentrations (25, 50, 100, 200, 400, and 800 μg/mL) against MCF-7 human breast cancer cells were analyzed. MTT assay findings suggest the increased accumulation of apoptotic bodies with the increasing concentration of MgFe2O4 nanoparticles in a dose-dependent manner. Flow cytometry analysis shows that MgFe2O4 nanoparticles in 800 μg/mL concentration are more cytotoxic compared to vehicle-treated MCF-7 cells and suggests their potential utility as a drug carrier in the treatment of cancer. |
| first_indexed | 2025-11-15T10:31:48Z |
| format | Article |
| id | upm-52210 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T10:31:48Z |
| publishDate | 2013 |
| publisher | Hindawi Publishing Corporation |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-522102017-06-05T05:05:04Z http://psasir.upm.edu.my/id/eprint/52210/ Cytotoxic effect of nanocrystalline MgFe2O4 particles for cancer cure Kanagesan, Samikannu Hashim, Mansor Subramani, Tamilselvan Mohammed Alitheen, Noorjahan Banu Ismail, Ismayadi Bahmanrokh, Ghazaleh Nanocrystalline magnesium ferrites (MgFe2O4) were produced with an average grain size of about 20 nm. Their structural, morphological, and magnetic characterizations were studied. The cytotoxic effects of MgFe2O4 nanoparticles in various concentrations (25, 50, 100, 200, 400, and 800 μg/mL) against MCF-7 human breast cancer cells were analyzed. MTT assay findings suggest the increased accumulation of apoptotic bodies with the increasing concentration of MgFe2O4 nanoparticles in a dose-dependent manner. Flow cytometry analysis shows that MgFe2O4 nanoparticles in 800 μg/mL concentration are more cytotoxic compared to vehicle-treated MCF-7 cells and suggests their potential utility as a drug carrier in the treatment of cancer. Hindawi Publishing Corporation 2013 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/52210/1/52210.pdf Kanagesan, Samikannu and Hashim, Mansor and Subramani, Tamilselvan and Mohammed Alitheen, Noorjahan Banu and Ismail, Ismayadi and Bahmanrokh, Ghazaleh (2013) Cytotoxic effect of nanocrystalline MgFe2O4 particles for cancer cure. Journal of Nanomaterials, 2013. art. no. 865024. pp. 1-8. ISSN 1687-4110; ESSN: 1687-4129 https://www.hindawi.com/journals/jnm/2013/865024/abs/ 10.1155/2013/865024 |
| spellingShingle | Kanagesan, Samikannu Hashim, Mansor Subramani, Tamilselvan Mohammed Alitheen, Noorjahan Banu Ismail, Ismayadi Bahmanrokh, Ghazaleh Cytotoxic effect of nanocrystalline MgFe2O4 particles for cancer cure |
| title | Cytotoxic effect of nanocrystalline MgFe2O4 particles for cancer cure |
| title_full | Cytotoxic effect of nanocrystalline MgFe2O4 particles for cancer cure |
| title_fullStr | Cytotoxic effect of nanocrystalline MgFe2O4 particles for cancer cure |
| title_full_unstemmed | Cytotoxic effect of nanocrystalline MgFe2O4 particles for cancer cure |
| title_short | Cytotoxic effect of nanocrystalline MgFe2O4 particles for cancer cure |
| title_sort | cytotoxic effect of nanocrystalline mgfe2o4 particles for cancer cure |
| url | http://psasir.upm.edu.my/id/eprint/52210/ http://psasir.upm.edu.my/id/eprint/52210/ http://psasir.upm.edu.my/id/eprint/52210/ http://psasir.upm.edu.my/id/eprint/52210/1/52210.pdf |