Characterisation of sol–gel method synthesised MgZnFe2O4 nanoparticles and its cytotoxic effects on breast cancer cell line, MDA MB-231 in vitro
In this study, nanocrystalline magnesium zinc ferrite nanoparticles were successfully prepared by a simple sol–gel method using copper nitrate and ferric nitrate as raw materials. The calcined samples were characterised by differential thermal analysis/thermogravimetric analysis, Fourier transform i...
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| Format: | Article |
| Language: | English |
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The Institution of Engineering and Technology
2017
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| Online Access: | http://psasir.upm.edu.my/id/eprint/52109/ http://psasir.upm.edu.my/id/eprint/52109/1/Characterisation%20of%20sol%E2%80%93gel%20method%20synthesised%20MgZnFe2O4%20nanoparticles%20and%20its%20cytotoxic%20effects%20on%20breast%20cancer%20cell%20line%2C%20MDA%20MB-231%20in%20vitro.pdf |
| _version_ | 1848852015622389760 |
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| author | Nordin, Noraini Kanagesan, Samikannu Zamberi, Nur Rizi Yeap, Swee Keong Abu, Nadiah Subramani, Tamilselvan Hashim, Mansor Mohammed Alitheen, Noorjahan Banu |
| author_facet | Nordin, Noraini Kanagesan, Samikannu Zamberi, Nur Rizi Yeap, Swee Keong Abu, Nadiah Subramani, Tamilselvan Hashim, Mansor Mohammed Alitheen, Noorjahan Banu |
| author_sort | Nordin, Noraini |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | In this study, nanocrystalline magnesium zinc ferrite nanoparticles were successfully prepared by a simple sol–gel method using copper nitrate and ferric nitrate as raw materials. The calcined samples were characterised by differential thermal analysis/thermogravimetric analysis, Fourier transform infrared spectroscopy and X-ray diffraction. Transmission electron microscopy revealed that the average particle size of the calcined sample was in a range of 17–41 nm with an average of 29 nm and has spherical size. A cytotoxicity test was performed on human breast cancer cells (MDA MB-231) and (MCF-7) at various concentrations starting from (0 µg/ml) to (800 µg/ml). The sample possessed a mild toxic effect toward MDA MB-231 and MCF-7 after being examined with MTT (3-[4, 5-dimethylthiazol-2-yl]-2, 5 diphenyltetrazolium bromide) assay for up to 72 h of incubation. Higher reduction of cells viability was observed as the concentration of sample was increased in MDA MB-231 cell line than in MCF-7. Therefore, further cytotoxicity tests were performed on MDA MB-231 cell line. |
| first_indexed | 2025-11-15T10:31:22Z |
| format | Article |
| id | upm-52109 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T10:31:22Z |
| publishDate | 2017 |
| publisher | The Institution of Engineering and Technology |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-521092017-05-05T02:58:19Z http://psasir.upm.edu.my/id/eprint/52109/ Characterisation of sol–gel method synthesised MgZnFe2O4 nanoparticles and its cytotoxic effects on breast cancer cell line, MDA MB-231 in vitro Nordin, Noraini Kanagesan, Samikannu Zamberi, Nur Rizi Yeap, Swee Keong Abu, Nadiah Subramani, Tamilselvan Hashim, Mansor Mohammed Alitheen, Noorjahan Banu In this study, nanocrystalline magnesium zinc ferrite nanoparticles were successfully prepared by a simple sol–gel method using copper nitrate and ferric nitrate as raw materials. The calcined samples were characterised by differential thermal analysis/thermogravimetric analysis, Fourier transform infrared spectroscopy and X-ray diffraction. Transmission electron microscopy revealed that the average particle size of the calcined sample was in a range of 17–41 nm with an average of 29 nm and has spherical size. A cytotoxicity test was performed on human breast cancer cells (MDA MB-231) and (MCF-7) at various concentrations starting from (0 µg/ml) to (800 µg/ml). The sample possessed a mild toxic effect toward MDA MB-231 and MCF-7 after being examined with MTT (3-[4, 5-dimethylthiazol-2-yl]-2, 5 diphenyltetrazolium bromide) assay for up to 72 h of incubation. Higher reduction of cells viability was observed as the concentration of sample was increased in MDA MB-231 cell line than in MCF-7. Therefore, further cytotoxicity tests were performed on MDA MB-231 cell line. The Institution of Engineering and Technology 2017 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/52109/1/Characterisation%20of%20sol%E2%80%93gel%20method%20synthesised%20MgZnFe2O4%20nanoparticles%20and%20its%20cytotoxic%20effects%20on%20breast%20cancer%20cell%20line%2C%20MDA%20MB-231%20in%20vitro.pdf Nordin, Noraini and Kanagesan, Samikannu and Zamberi, Nur Rizi and Yeap, Swee Keong and Abu, Nadiah and Subramani, Tamilselvan and Hashim, Mansor and Mohammed Alitheen, Noorjahan Banu (2017) Characterisation of sol–gel method synthesised MgZnFe2O4 nanoparticles and its cytotoxic effects on breast cancer cell line, MDA MB-231 in vitro. IET Nanobiotechnology, 11 (3). pp. 343-348. ISSN 1751-8741; ESSN: 1751-875X http://digital-library.theiet.org/content/journals/10.1049/iet-nbt.2016.0007 10.1049/iet-nbt.2016.0007 |
| spellingShingle | Nordin, Noraini Kanagesan, Samikannu Zamberi, Nur Rizi Yeap, Swee Keong Abu, Nadiah Subramani, Tamilselvan Hashim, Mansor Mohammed Alitheen, Noorjahan Banu Characterisation of sol–gel method synthesised MgZnFe2O4 nanoparticles and its cytotoxic effects on breast cancer cell line, MDA MB-231 in vitro |
| title | Characterisation of sol–gel method synthesised MgZnFe2O4 nanoparticles and its cytotoxic effects on breast cancer cell line, MDA MB-231 in vitro |
| title_full | Characterisation of sol–gel method synthesised MgZnFe2O4 nanoparticles and its cytotoxic effects on breast cancer cell line, MDA MB-231 in vitro |
| title_fullStr | Characterisation of sol–gel method synthesised MgZnFe2O4 nanoparticles and its cytotoxic effects on breast cancer cell line, MDA MB-231 in vitro |
| title_full_unstemmed | Characterisation of sol–gel method synthesised MgZnFe2O4 nanoparticles and its cytotoxic effects on breast cancer cell line, MDA MB-231 in vitro |
| title_short | Characterisation of sol–gel method synthesised MgZnFe2O4 nanoparticles and its cytotoxic effects on breast cancer cell line, MDA MB-231 in vitro |
| title_sort | characterisation of sol–gel method synthesised mgznfe2o4 nanoparticles and its cytotoxic effects on breast cancer cell line, mda mb-231 in vitro |
| url | http://psasir.upm.edu.my/id/eprint/52109/ http://psasir.upm.edu.my/id/eprint/52109/ http://psasir.upm.edu.my/id/eprint/52109/ http://psasir.upm.edu.my/id/eprint/52109/1/Characterisation%20of%20sol%E2%80%93gel%20method%20synthesised%20MgZnFe2O4%20nanoparticles%20and%20its%20cytotoxic%20effects%20on%20breast%20cancer%20cell%20line%2C%20MDA%20MB-231%20in%20vitro.pdf |