Xanthones from Calophyllum inophyllum
Repeated separation and purification of fractions from the crude chloroform extract of Calophyllum inophyllum via column chromatography afforded five known xanthone caloxanthones A, B, C, macluraxanthone and pyranojacareubin. Structural elucidations and determination of the isolated compounds were s...
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| Format: | Article |
| Language: | English |
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Universiti Putra Malaysia Press
2017
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| Online Access: | http://psasir.upm.edu.my/id/eprint/51636/ http://psasir.upm.edu.my/id/eprint/51636/1/8-JTAS-0869-2016-5thProof.pdf |
| _version_ | 1848851885459505152 |
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| author | Lee, Kar Wei Ee, Gwendoline Cheng Lian Daud, Shaari Karunakaran, Thiruventhan |
| author_facet | Lee, Kar Wei Ee, Gwendoline Cheng Lian Daud, Shaari Karunakaran, Thiruventhan |
| author_sort | Lee, Kar Wei |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Repeated separation and purification of fractions from the crude chloroform extract of Calophyllum inophyllum via column chromatography afforded five known xanthone caloxanthones A, B, C, macluraxanthone and pyranojacareubin. Structural elucidations and determination of the isolated compounds were supported by spectral analyses obtained by subjecting the compounds to various spectroscopic techniques. The chloroform extract, when tested against RAW264.7 cells for anti-inflammatory potentials, exhibited the most promising activity with an IC50 value of 14.81±0.04 µg/mL compared to moderate activities shown by the ethyl acetate and n-hexane extracts. Antimicrobial tests showed that the n-hexane and chloroform extracts acted moderately against Staphylococcus epidermidis S273 and Bacillus subtilis B145. |
| first_indexed | 2025-11-15T10:29:17Z |
| format | Article |
| id | upm-51636 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T10:29:17Z |
| publishDate | 2017 |
| publisher | Universiti Putra Malaysia Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-516362017-04-05T05:27:53Z http://psasir.upm.edu.my/id/eprint/51636/ Xanthones from Calophyllum inophyllum Lee, Kar Wei Ee, Gwendoline Cheng Lian Daud, Shaari Karunakaran, Thiruventhan Repeated separation and purification of fractions from the crude chloroform extract of Calophyllum inophyllum via column chromatography afforded five known xanthone caloxanthones A, B, C, macluraxanthone and pyranojacareubin. Structural elucidations and determination of the isolated compounds were supported by spectral analyses obtained by subjecting the compounds to various spectroscopic techniques. The chloroform extract, when tested against RAW264.7 cells for anti-inflammatory potentials, exhibited the most promising activity with an IC50 value of 14.81±0.04 µg/mL compared to moderate activities shown by the ethyl acetate and n-hexane extracts. Antimicrobial tests showed that the n-hexane and chloroform extracts acted moderately against Staphylococcus epidermidis S273 and Bacillus subtilis B145. Universiti Putra Malaysia Press 2017 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/51636/1/8-JTAS-0869-2016-5thProof.pdf Lee, Kar Wei and Ee, Gwendoline Cheng Lian and Daud, Shaari and Karunakaran, Thiruventhan (2017) Xanthones from Calophyllum inophyllum. Pertanika Journal of Tropical Agricultural Science, 40 (1). pp. 111-118. ISSN 1511-3701; ESSN: 2231-8542 http://www.pertanika.upm.edu.my/Pertanika%20PAPERS/JTAS%20Vol.%2040%20(1)%20Feb.%202017/8-JTAS-0869-2016-5thProof.pdf |
| spellingShingle | Lee, Kar Wei Ee, Gwendoline Cheng Lian Daud, Shaari Karunakaran, Thiruventhan Xanthones from Calophyllum inophyllum |
| title | Xanthones from Calophyllum inophyllum |
| title_full | Xanthones from Calophyllum inophyllum |
| title_fullStr | Xanthones from Calophyllum inophyllum |
| title_full_unstemmed | Xanthones from Calophyllum inophyllum |
| title_short | Xanthones from Calophyllum inophyllum |
| title_sort | xanthones from calophyllum inophyllum |
| url | http://psasir.upm.edu.my/id/eprint/51636/ http://psasir.upm.edu.my/id/eprint/51636/ http://psasir.upm.edu.my/id/eprint/51636/1/8-JTAS-0869-2016-5thProof.pdf |