The effect of experimental fascioliasis on the pharmacokinetics of antipyrine and sulphadimidine in desert sheep
Healthy adult male desert sheep were experimentally infected with Fasciola gigantica, to investigate the influence of experimental fasciolasis on the pharmacokinetics of antipyrine and sulphadimidine. Each animal received 500 metacercariae orally. The experimental infection was confirmed histologica...
| Main Authors: | , |
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| Format: | Article |
| Language: | English English |
| Published: |
Blackwell Science
1997
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| Online Access: | http://psasir.upm.edu.my/id/eprint/51105/ http://psasir.upm.edu.my/id/eprint/51105/1/51105.pdf http://psasir.upm.edu.my/id/eprint/51105/7/51105.pdf |
| _version_ | 1848851742993678336 |
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| author | Elsheikh, Hatim Ali Ali, Badreldin H. |
| author_facet | Elsheikh, Hatim Ali Ali, Badreldin H. |
| author_sort | Elsheikh, Hatim Ali |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Healthy adult male desert sheep were experimentally infected with Fasciola gigantica, to investigate the influence of experimental fasciolasis on the pharmacokinetics of antipyrine and sulphadimidine. Each animal received 500 metacercariae orally. The experimental infection was confirmed histologically, by detection of Fasciola eggs in faeces and by measuring the activities of the enzymes sorbitol dehydrogenase (SD), glutamate dehydrogenase (GD) and aspartate aminotransferase (AST) in plasma during the course of the disease. Changes in the pharmacokinetics of antipyrine and sulphadimidine were reported in the experimentally infected animals. Significant prolongation of antipyrine half life was observed 16 weeks after infection. The half-life of sulphadimidine was also significantly prolonged 5, 9 and 16 weeks after infection. Clearance of the sulphonamide was decreased significantly 5 and 9 weeks after infection and it regained its pre-infection value 16 weeks after infection. |
| first_indexed | 2025-11-15T10:27:02Z |
| format | Article |
| id | upm-51105 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-15T10:27:02Z |
| publishDate | 1997 |
| publisher | Blackwell Science |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-511052024-10-15T04:15:01Z http://psasir.upm.edu.my/id/eprint/51105/ The effect of experimental fascioliasis on the pharmacokinetics of antipyrine and sulphadimidine in desert sheep Elsheikh, Hatim Ali Ali, Badreldin H. Healthy adult male desert sheep were experimentally infected with Fasciola gigantica, to investigate the influence of experimental fasciolasis on the pharmacokinetics of antipyrine and sulphadimidine. Each animal received 500 metacercariae orally. The experimental infection was confirmed histologically, by detection of Fasciola eggs in faeces and by measuring the activities of the enzymes sorbitol dehydrogenase (SD), glutamate dehydrogenase (GD) and aspartate aminotransferase (AST) in plasma during the course of the disease. Changes in the pharmacokinetics of antipyrine and sulphadimidine were reported in the experimentally infected animals. Significant prolongation of antipyrine half life was observed 16 weeks after infection. The half-life of sulphadimidine was also significantly prolonged 5, 9 and 16 weeks after infection. Clearance of the sulphonamide was decreased significantly 5 and 9 weeks after infection and it regained its pre-infection value 16 weeks after infection. Blackwell Science 1997 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/51105/1/51105.pdf text en http://psasir.upm.edu.my/id/eprint/51105/7/51105.pdf Elsheikh, Hatim Ali and Ali, Badreldin H. (1997) The effect of experimental fascioliasis on the pharmacokinetics of antipyrine and sulphadimidine in desert sheep. Journal of Veterinary Pharmacology and Therapeutics, 20 (3). pp. 167-172. ISSN 0140-7783; eISSN: 1365-2885 http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2885.1997.tb00091.x/abstract 10.1111/j.1365-2885.1997.tb00091.x |
| spellingShingle | Elsheikh, Hatim Ali Ali, Badreldin H. The effect of experimental fascioliasis on the pharmacokinetics of antipyrine and sulphadimidine in desert sheep |
| title | The effect of experimental fascioliasis on the pharmacokinetics of antipyrine and sulphadimidine in desert sheep |
| title_full | The effect of experimental fascioliasis on the pharmacokinetics of antipyrine and sulphadimidine in desert sheep |
| title_fullStr | The effect of experimental fascioliasis on the pharmacokinetics of antipyrine and sulphadimidine in desert sheep |
| title_full_unstemmed | The effect of experimental fascioliasis on the pharmacokinetics of antipyrine and sulphadimidine in desert sheep |
| title_short | The effect of experimental fascioliasis on the pharmacokinetics of antipyrine and sulphadimidine in desert sheep |
| title_sort | effect of experimental fascioliasis on the pharmacokinetics of antipyrine and sulphadimidine in desert sheep |
| url | http://psasir.upm.edu.my/id/eprint/51105/ http://psasir.upm.edu.my/id/eprint/51105/ http://psasir.upm.edu.my/id/eprint/51105/ http://psasir.upm.edu.my/id/eprint/51105/1/51105.pdf http://psasir.upm.edu.my/id/eprint/51105/7/51105.pdf |