Preliminary study on antinociceptove effect of aqueous extract of Boesenbergia pandurata in formalin-induced nociception test in mice
Pain is an unpleasant sensation associated with body state dysfunction that negatively affects the productivity of patients. Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used as over-the-counter pain reliever medication due to its cost effectiveness. However, prolonged usage of NSAIDs...
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| Format: | Conference or Workshop Item |
| Language: | English |
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Department of Biology, Faculty of Science, Universiti Putra Malaysia
2014
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| Online Access: | http://psasir.upm.edu.my/id/eprint/49856/ http://psasir.upm.edu.my/id/eprint/49856/1/BIO%202014-74.pdf |
| _version_ | 1848851389005955072 |
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| author | Ee, Ai Chin Omar Farouk, Ahmad Akira Perimal, Enoch Kumar Israf Ali, Daud Ahmad Lee, Ming Tatt Sulaiman, Mohd Roslan |
| author_facet | Ee, Ai Chin Omar Farouk, Ahmad Akira Perimal, Enoch Kumar Israf Ali, Daud Ahmad Lee, Ming Tatt Sulaiman, Mohd Roslan |
| author_sort | Ee, Ai Chin |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Pain is an unpleasant sensation associated with body state dysfunction that negatively affects the productivity of patients. Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used as over-the-counter pain reliever medication due to its cost effectiveness. However, prolonged usage of NSAIDs usually accompanied with adverse side effects such as ulcer, nausea and even kidney failure. Hence, researchers are now focused on traditional herbal research to search for potential analgesic substances that are with minimal or no adverse effects. Boesenbergia pandurata，it is also known as temu kunci in Malaysia is a perennial herb that belongs to Zingiberaceae family. Boesenbergia pandurata is widely distributed in Southeast Asia and its rhizomes are commonly used as food ingredients or as traditional medicine to treat diseases conditions such as inflammation, cancer, and fungal infection. The aim of this study is to evaluate the inhibitory effect of aqueous extract of Boesenbergia pandurata (AEBP) on formalin-induced nociception test in mice. Mice were pre-treated with AEBP via intraperitoneal injection 30 min before challenged with intraplantar injection of formalin. It was demonstrated that intraperitoneal administration of AEBP at doses (0.3, 1, 3 and 10 mg/kg) produced significant antinociceptive response in both neurogenic and inflammatory phases of pain response induced by formalin. The findings indicated preliminary study on antinociceptive effect of AEBP, but further study should be conducted to explore the exact mechanism of pain inhibition by AEBP. |
| first_indexed | 2025-11-15T10:21:24Z |
| format | Conference or Workshop Item |
| id | upm-49856 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T10:21:24Z |
| publishDate | 2014 |
| publisher | Department of Biology, Faculty of Science, Universiti Putra Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-498562020-04-14T14:20:01Z http://psasir.upm.edu.my/id/eprint/49856/ Preliminary study on antinociceptove effect of aqueous extract of Boesenbergia pandurata in formalin-induced nociception test in mice Ee, Ai Chin Omar Farouk, Ahmad Akira Perimal, Enoch Kumar Israf Ali, Daud Ahmad Lee, Ming Tatt Sulaiman, Mohd Roslan Pain is an unpleasant sensation associated with body state dysfunction that negatively affects the productivity of patients. Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used as over-the-counter pain reliever medication due to its cost effectiveness. However, prolonged usage of NSAIDs usually accompanied with adverse side effects such as ulcer, nausea and even kidney failure. Hence, researchers are now focused on traditional herbal research to search for potential analgesic substances that are with minimal or no adverse effects. Boesenbergia pandurata，it is also known as temu kunci in Malaysia is a perennial herb that belongs to Zingiberaceae family. Boesenbergia pandurata is widely distributed in Southeast Asia and its rhizomes are commonly used as food ingredients or as traditional medicine to treat diseases conditions such as inflammation, cancer, and fungal infection. The aim of this study is to evaluate the inhibitory effect of aqueous extract of Boesenbergia pandurata (AEBP) on formalin-induced nociception test in mice. Mice were pre-treated with AEBP via intraperitoneal injection 30 min before challenged with intraplantar injection of formalin. It was demonstrated that intraperitoneal administration of AEBP at doses (0.3, 1, 3 and 10 mg/kg) produced significant antinociceptive response in both neurogenic and inflammatory phases of pain response induced by formalin. The findings indicated preliminary study on antinociceptive effect of AEBP, but further study should be conducted to explore the exact mechanism of pain inhibition by AEBP. Department of Biology, Faculty of Science, Universiti Putra Malaysia 2014 Conference or Workshop Item PeerReviewed text en http://psasir.upm.edu.my/id/eprint/49856/1/BIO%202014-74.pdf Ee, Ai Chin and Omar Farouk, Ahmad Akira and Perimal, Enoch Kumar and Israf Ali, Daud Ahmad and Lee, Ming Tatt and Sulaiman, Mohd Roslan (2014) Preliminary study on antinociceptove effect of aqueous extract of Boesenbergia pandurata in formalin-induced nociception test in mice. In: Malaysia International Biological Symposium 2014, 28-29 Oct. 2014, Putrajaya, Malaysia. (p. 296). |
| spellingShingle | Ee, Ai Chin Omar Farouk, Ahmad Akira Perimal, Enoch Kumar Israf Ali, Daud Ahmad Lee, Ming Tatt Sulaiman, Mohd Roslan Preliminary study on antinociceptove effect of aqueous extract of Boesenbergia pandurata in formalin-induced nociception test in mice |
| title | Preliminary study on antinociceptove effect of aqueous extract of Boesenbergia pandurata in formalin-induced nociception test in mice |
| title_full | Preliminary study on antinociceptove effect of aqueous extract of Boesenbergia pandurata in formalin-induced nociception test in mice |
| title_fullStr | Preliminary study on antinociceptove effect of aqueous extract of Boesenbergia pandurata in formalin-induced nociception test in mice |
| title_full_unstemmed | Preliminary study on antinociceptove effect of aqueous extract of Boesenbergia pandurata in formalin-induced nociception test in mice |
| title_short | Preliminary study on antinociceptove effect of aqueous extract of Boesenbergia pandurata in formalin-induced nociception test in mice |
| title_sort | preliminary study on antinociceptove effect of aqueous extract of boesenbergia pandurata in formalin-induced nociception test in mice |
| url | http://psasir.upm.edu.my/id/eprint/49856/ http://psasir.upm.edu.my/id/eprint/49856/1/BIO%202014-74.pdf |