Acute and subchronic toxicity studies of an aqueous extract of Morinda citrifolia fruit in rats
This experiment was conducted to evaluate the toxicity of an aqueous extract Morinda citrifolia fruit on Sprague-Dawley male rats through acute (LD50) and subchronic studies. In the LD50 test, rats were given three dosages of M. citrifolia extracts (1.0, 2.0 and 3.0 g/kg of body weight). They were o...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Malaysian Agricultural Research and Development Institute (MARDI)
2003
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/48890/ http://psasir.upm.edu.my/id/eprint/48890/1/Acute%20and%20subchronic%20toxicity%20studies%20of%20an%20aqueous%20extract%20of%20Morinda%20citrifolia%20fruit%20in%20rats.pdf |
| _version_ | 1848851213085310976 |
|---|---|
| author | Hassan, Hadijah Mohd Yatim, Ayub Hambali, Zarida Ahamad, Normah |
| author_facet | Hassan, Hadijah Mohd Yatim, Ayub Hambali, Zarida Ahamad, Normah |
| author_sort | Hassan, Hadijah |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | This experiment was conducted to evaluate the toxicity of an aqueous extract Morinda citrifolia fruit on Sprague-Dawley male rats through acute (LD50) and subchronic studies. In the LD50 test, rats were given three dosages of M. citrifolia extracts (1.0, 2.0 and 3.0 g/kg of body weight). They were observed for any toxic signs, especially death for the first 24 hours and continued up to 14 days. In the subchronic study, effects of M. citrifolia extracts in rats (0.25, 0.50 and 1.0 g/kg of body weight) were determined for 6 weeks by measuring the blood biochemical parameters such as plasma glucose, cholesterol, triglyceride, total protein, albumin, urea, creatinine and enzymes (aspartate transaminase, alanine transaminase, alkaline phosphatase, lactate dehydrogenase and γ glutamyl transferase). |
| first_indexed | 2025-11-15T10:18:36Z |
| format | Article |
| id | upm-48890 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T10:18:36Z |
| publishDate | 2003 |
| publisher | Malaysian Agricultural Research and Development Institute (MARDI) |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-488902016-12-29T09:48:22Z http://psasir.upm.edu.my/id/eprint/48890/ Acute and subchronic toxicity studies of an aqueous extract of Morinda citrifolia fruit in rats Hassan, Hadijah Mohd Yatim, Ayub Hambali, Zarida Ahamad, Normah This experiment was conducted to evaluate the toxicity of an aqueous extract Morinda citrifolia fruit on Sprague-Dawley male rats through acute (LD50) and subchronic studies. In the LD50 test, rats were given three dosages of M. citrifolia extracts (1.0, 2.0 and 3.0 g/kg of body weight). They were observed for any toxic signs, especially death for the first 24 hours and continued up to 14 days. In the subchronic study, effects of M. citrifolia extracts in rats (0.25, 0.50 and 1.0 g/kg of body weight) were determined for 6 weeks by measuring the blood biochemical parameters such as plasma glucose, cholesterol, triglyceride, total protein, albumin, urea, creatinine and enzymes (aspartate transaminase, alanine transaminase, alkaline phosphatase, lactate dehydrogenase and γ glutamyl transferase). Malaysian Agricultural Research and Development Institute (MARDI) 2003 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/48890/1/Acute%20and%20subchronic%20toxicity%20studies%20of%20an%20aqueous%20extract%20of%20Morinda%20citrifolia%20fruit%20in%20rats.pdf Hassan, Hadijah and Mohd Yatim, Ayub and Hambali, Zarida and Ahamad, Normah (2003) Acute and subchronic toxicity studies of an aqueous extract of Morinda citrifolia fruit in rats. Journal of Tropical Agriculture and Food Science, 31 (1). pp. 67-73. ISSN 1394-9829; ESSN: 2289-9650 http://ejtafs.mardi.gov.my/index.php/publication/issues/archive/77-2003/volume-31-no1/461-310112 |
| spellingShingle | Hassan, Hadijah Mohd Yatim, Ayub Hambali, Zarida Ahamad, Normah Acute and subchronic toxicity studies of an aqueous extract of Morinda citrifolia fruit in rats |
| title | Acute and subchronic toxicity studies of an aqueous extract of Morinda citrifolia fruit in rats |
| title_full | Acute and subchronic toxicity studies of an aqueous extract of Morinda citrifolia fruit in rats |
| title_fullStr | Acute and subchronic toxicity studies of an aqueous extract of Morinda citrifolia fruit in rats |
| title_full_unstemmed | Acute and subchronic toxicity studies of an aqueous extract of Morinda citrifolia fruit in rats |
| title_short | Acute and subchronic toxicity studies of an aqueous extract of Morinda citrifolia fruit in rats |
| title_sort | acute and subchronic toxicity studies of an aqueous extract of morinda citrifolia fruit in rats |
| url | http://psasir.upm.edu.my/id/eprint/48890/ http://psasir.upm.edu.my/id/eprint/48890/ http://psasir.upm.edu.my/id/eprint/48890/1/Acute%20and%20subchronic%20toxicity%20studies%20of%20an%20aqueous%20extract%20of%20Morinda%20citrifolia%20fruit%20in%20rats.pdf |