Effects of bortezomib on HIF-1 and HIF-2 transcriptional activities

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Effects of bortezomib on HIF-1 and HIF-2 transcriptional activities

Bortezomib is the first proteasomal inhibitor (PI) to be used therapeutically in humans for treating relapse cases of multiple myeloma and mantle cell lymphoma. A proposed mechanism is that it prevents proteasomal degradation of pro-apoptotic proteins, leading to enhance apoptosis. Although the alp...

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Bibliographic Details
Main Author:	Abd Aziz, Noraini
Format:	Thesis
Language:	English
Published:	2013
Subjects:	Protease inhibitors - Therapeutic use Cancer - Chemotherapy
Online Access:	http://psasir.upm.edu.my/id/eprint/48690/ http://psasir.upm.edu.my/id/eprint/48690/1/FBSB%202013%2039R.pdf

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