Screening for the in vitro anti-tumor-promoting activities of edible plants from Malaysia
A total of 114 methanol extracts from 42 plant families of edible Malaysian plants were screened for their inhibitory activities toward tumor promoter 12-O-hexadecanoylphorbol-13-acetate (HPA)-induced Epstein-Barr virus (EBV) activation in Raji cells. By testing at a concentration of 200 μg/ml, 74%...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English English |
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Japan Society for Bioscience, Biotechnology, and Agrochemistry
2000
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| Online Access: | http://psasir.upm.edu.my/id/eprint/48662/ http://psasir.upm.edu.my/id/eprint/48662/1/Screening%20for%20the%20in%20vitro%20anti-tumor-promoting%20activities%20of%20edible%20plants%20from%20Malaysia.pdf http://psasir.upm.edu.my/id/eprint/48662/7/bbb0009.pdf |
| _version_ | 1848851150032338944 |
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| author | Murakami, Akira Ali, Abdul Manaf Mat Salleh, Kamaruddin Koshimizu, Koichi Ohigashi, Hajime |
| author_facet | Murakami, Akira Ali, Abdul Manaf Mat Salleh, Kamaruddin Koshimizu, Koichi Ohigashi, Hajime |
| author_sort | Murakami, Akira |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | A total of 114 methanol extracts from 42 plant families of edible Malaysian plants were screened for their inhibitory activities toward tumor promoter 12-O-hexadecanoylphorbol-13-acetate (HPA)-induced Epstein-Barr virus (EBV) activation in Raji cells. By testing at a concentration of 200 μg/ml, 74% of the 114 extracts inhibited EBV activation by 30% or more. This rate is comparable to those observed in the previous tests on edible Thai (60%) and Indonesian (71%) plants, and, importantly, much higher than that (26%) observed for Japanese edible plants. Approximately half of the Malaysian plants did not taxonomically overlap those from the other three countries, suggesting that Malaysian plants, as well as Thai and Indonesian plants, are an exclusive source of effective chemopreventive agents. Further dilution experiments indicated an extract from the leaves of Piper betle L. (Piperaceae) to be one of the most promising species. The high potential of edible Southeast Asian plants for cancer chemoprevention is collectively discussed. |
| first_indexed | 2025-11-15T10:17:36Z |
| format | Article |
| id | upm-48662 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-15T10:17:36Z |
| publishDate | 2000 |
| publisher | Japan Society for Bioscience, Biotechnology, and Agrochemistry |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-486622024-07-26T07:45:16Z http://psasir.upm.edu.my/id/eprint/48662/ Screening for the in vitro anti-tumor-promoting activities of edible plants from Malaysia Murakami, Akira Ali, Abdul Manaf Mat Salleh, Kamaruddin Koshimizu, Koichi Ohigashi, Hajime A total of 114 methanol extracts from 42 plant families of edible Malaysian plants were screened for their inhibitory activities toward tumor promoter 12-O-hexadecanoylphorbol-13-acetate (HPA)-induced Epstein-Barr virus (EBV) activation in Raji cells. By testing at a concentration of 200 μg/ml, 74% of the 114 extracts inhibited EBV activation by 30% or more. This rate is comparable to those observed in the previous tests on edible Thai (60%) and Indonesian (71%) plants, and, importantly, much higher than that (26%) observed for Japanese edible plants. Approximately half of the Malaysian plants did not taxonomically overlap those from the other three countries, suggesting that Malaysian plants, as well as Thai and Indonesian plants, are an exclusive source of effective chemopreventive agents. Further dilution experiments indicated an extract from the leaves of Piper betle L. (Piperaceae) to be one of the most promising species. The high potential of edible Southeast Asian plants for cancer chemoprevention is collectively discussed. Japan Society for Bioscience, Biotechnology, and Agrochemistry 2000 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/48662/1/Screening%20for%20the%20in%20vitro%20anti-tumor-promoting%20activities%20of%20edible%20plants%20from%20Malaysia.pdf text en http://psasir.upm.edu.my/id/eprint/48662/7/bbb0009.pdf Murakami, Akira and Ali, Abdul Manaf and Mat Salleh, Kamaruddin and Koshimizu, Koichi and Ohigashi, Hajime (2000) Screening for the in vitro anti-tumor-promoting activities of edible plants from Malaysia. Bioscience, Biotechnology, and Biochemistry, 64 (1). pp. 9-16. ISSN 0916-8451; ESSN: 1347-6947 https://www.jstage.jst.go.jp/article/bbb/64/1/64_1_9/_article 10.1271/bbb.64.9 |
| spellingShingle | Murakami, Akira Ali, Abdul Manaf Mat Salleh, Kamaruddin Koshimizu, Koichi Ohigashi, Hajime Screening for the in vitro anti-tumor-promoting activities of edible plants from Malaysia |
| title | Screening for the in vitro anti-tumor-promoting activities of edible plants from Malaysia |
| title_full | Screening for the in vitro anti-tumor-promoting activities of edible plants from Malaysia |
| title_fullStr | Screening for the in vitro anti-tumor-promoting activities of edible plants from Malaysia |
| title_full_unstemmed | Screening for the in vitro anti-tumor-promoting activities of edible plants from Malaysia |
| title_short | Screening for the in vitro anti-tumor-promoting activities of edible plants from Malaysia |
| title_sort | screening for the in vitro anti-tumor-promoting activities of edible plants from malaysia |
| url | http://psasir.upm.edu.my/id/eprint/48662/ http://psasir.upm.edu.my/id/eprint/48662/ http://psasir.upm.edu.my/id/eprint/48662/ http://psasir.upm.edu.my/id/eprint/48662/1/Screening%20for%20the%20in%20vitro%20anti-tumor-promoting%20activities%20of%20edible%20plants%20from%20Malaysia.pdf http://psasir.upm.edu.my/id/eprint/48662/7/bbb0009.pdf |