Antinociceptive and anti-inflammatory properties of Corchorus capsularis leaves chloroform extract in experimental animal models
The antinociceptive and anti-inflammatory properties of Corchorus capsularis leaves chloroform extract were investigated in experimental animal models. The antinociceptive activity was measured using the writhing, hot plate and formalin tests, while the anti-inflammatory activity was measured using...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
The Pharmaceutical Society of Japan
2007
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| Online Access: | http://psasir.upm.edu.my/id/eprint/48570/ http://psasir.upm.edu.my/id/eprint/48570/1/Antinociceptive%20and%20anti-inflammatory%20properties%20of%20Corchorus%20capsularis%20leaves%20chloroform%20extract%20in%20experimental%20animal%20models.pdf |
| Summary: | The antinociceptive and anti-inflammatory properties of Corchorus capsularis leaves chloroform extract were investigated in experimental animal models. The antinociceptive activity was measured using the writhing, hot plate and formalin tests, while the anti-inflammatory activity was measured using the carrageenan-induced paw edema test. The extract, obtained after 72 h soaking of the air-dried leaves in chloroform followed by in vacuo evaporation to dryness, was weighed and prepared by serial dilution in DMSO in the doses of 20, 100 and 200 mg/kg. The extract was administered (s.c.) 30 min prior to subjection to the respective assays. The extract was found to exhibit significant (p<0.05) antinociceptive and anti-inflammatory activities. As a conclusion, the present study confirmed the traditional claims of using C. capsularis to treat various ailments related to inflammation and pain. |
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