γ-secretase inhibitors and modulators induce distinct conformational changes in the active sites of γ-secretase and signal peptide peptidase

γ-secretase inhibitors and modulators induce distinct conformational changes in the active sites of γ-secretase and signal peptide peptidase

γ-Secretase inhibitors (GSIs) and modulators (GSMs) are at the frontline of cancer and Alzheimer’s disease research, respectively. While both are therapeutically promising, not much is known about their interactions with proteins other than γ-secretase. Signal peptide peptidase (SPP), like γ-secreta...

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Bibliographic Details
Main Authors: Gertsik, Natalya, Chau, De Ming, Li, Yue Ming
Format: Article
Language:English
Published: American Chemical Society 2015
Online Access:http://psasir.upm.edu.my/id/eprint/46916/
http://psasir.upm.edu.my/id/eprint/46916/1/%CE%B3-secretase%20inhibitors%20and%20modulators%20induce%20distinct%20conformational%20changes%20in%20the%20active%20sites%20of%20%CE%B3-secretase%20and%20signal%20peptide%20peptidase.pdf

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