Xanthorrhizol: a review of its pharmacological activities and anticancer properties
Xanthorrhizol (XNT) is a bisabolane-type sesquiterpenoid compound extracted from Curcuma xanthorrhiza Roxb. It has been well established to possess a variety of biological activities such as anticancer, antimicrobial, anti-inflammatory, antioxidant, antihyperglycemic, antihypertensive, antiplatelet,...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BioMed Central
2015
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| Online Access: | http://psasir.upm.edu.my/id/eprint/46908/ http://psasir.upm.edu.my/id/eprint/46908/1/Xanthorrhizol%3B%20a%20review%20of%20its%20pharmacological%20activities%20and%20anticancer%20properties.pdf |
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| author | Oon, Seok Fang Nallappan, Meenakshii Tee, Thiam Tsui Shohaimi, Shamarina Kassim, Nur Kartinee Sa'ariwijaya, Mohd Shazrul Fazry Cheah, Yew Hoong |
| author_facet | Oon, Seok Fang Nallappan, Meenakshii Tee, Thiam Tsui Shohaimi, Shamarina Kassim, Nur Kartinee Sa'ariwijaya, Mohd Shazrul Fazry Cheah, Yew Hoong |
| author_sort | Oon, Seok Fang |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Xanthorrhizol (XNT) is a bisabolane-type sesquiterpenoid compound extracted from Curcuma xanthorrhiza Roxb. It has been well established to possess a variety of biological activities such as anticancer, antimicrobial, anti-inflammatory, antioxidant, antihyperglycemic, antihypertensive, antiplatelet, nephroprotective, hepatoprotective, estrogenic and anti-estrogenic effects. Since many synthetic drugs possess toxic side effects and are unable to support the increasing prevalence of disease, there is significant interest in developing natural product as new therapeutics. XNT is a very potent natural bioactive compound that could fulfil the current need for new drug discovery. Despite its importance, a comprehensive review of XNT’s pharmacological activities has not been published in the scientific literature to date. Here, the present review aims to summarize the available information in this area, focus on its anticancer properties and indicate the current status of the research. This helps to facilitate the understanding of XNT’s pharmacological role in drug discovery, thus suggesting areas where further research is required. |
| first_indexed | 2025-11-15T10:11:24Z |
| format | Article |
| id | upm-46908 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T10:11:24Z |
| publishDate | 2015 |
| publisher | BioMed Central |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-469082022-05-25T03:35:13Z http://psasir.upm.edu.my/id/eprint/46908/ Xanthorrhizol: a review of its pharmacological activities and anticancer properties Oon, Seok Fang Nallappan, Meenakshii Tee, Thiam Tsui Shohaimi, Shamarina Kassim, Nur Kartinee Sa'ariwijaya, Mohd Shazrul Fazry Cheah, Yew Hoong Xanthorrhizol (XNT) is a bisabolane-type sesquiterpenoid compound extracted from Curcuma xanthorrhiza Roxb. It has been well established to possess a variety of biological activities such as anticancer, antimicrobial, anti-inflammatory, antioxidant, antihyperglycemic, antihypertensive, antiplatelet, nephroprotective, hepatoprotective, estrogenic and anti-estrogenic effects. Since many synthetic drugs possess toxic side effects and are unable to support the increasing prevalence of disease, there is significant interest in developing natural product as new therapeutics. XNT is a very potent natural bioactive compound that could fulfil the current need for new drug discovery. Despite its importance, a comprehensive review of XNT’s pharmacological activities has not been published in the scientific literature to date. Here, the present review aims to summarize the available information in this area, focus on its anticancer properties and indicate the current status of the research. This helps to facilitate the understanding of XNT’s pharmacological role in drug discovery, thus suggesting areas where further research is required. BioMed Central 2015 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/46908/1/Xanthorrhizol%3B%20a%20review%20of%20its%20pharmacological%20activities%20and%20anticancer%20properties.pdf Oon, Seok Fang and Nallappan, Meenakshii and Tee, Thiam Tsui and Shohaimi, Shamarina and Kassim, Nur Kartinee and Sa'ariwijaya, Mohd Shazrul Fazry and Cheah, Yew Hoong (2015) Xanthorrhizol: a review of its pharmacological activities and anticancer properties. Cancer Cell International, 15. art. no. 100. pp. 1-15. ISSN 1475-2867 https://cancerci.biomedcentral.com/articles/10.1186/s12935-015-0255-4 10.1186/s12935-015-0255-4 |
| spellingShingle | Oon, Seok Fang Nallappan, Meenakshii Tee, Thiam Tsui Shohaimi, Shamarina Kassim, Nur Kartinee Sa'ariwijaya, Mohd Shazrul Fazry Cheah, Yew Hoong Xanthorrhizol: a review of its pharmacological activities and anticancer properties |
| title | Xanthorrhizol: a review of its pharmacological activities and anticancer properties |
| title_full | Xanthorrhizol: a review of its pharmacological activities and anticancer properties |
| title_fullStr | Xanthorrhizol: a review of its pharmacological activities and anticancer properties |
| title_full_unstemmed | Xanthorrhizol: a review of its pharmacological activities and anticancer properties |
| title_short | Xanthorrhizol: a review of its pharmacological activities and anticancer properties |
| title_sort | xanthorrhizol: a review of its pharmacological activities and anticancer properties |
| url | http://psasir.upm.edu.my/id/eprint/46908/ http://psasir.upm.edu.my/id/eprint/46908/ http://psasir.upm.edu.my/id/eprint/46908/ http://psasir.upm.edu.my/id/eprint/46908/1/Xanthorrhizol%3B%20a%20review%20of%20its%20pharmacological%20activities%20and%20anticancer%20properties.pdf |