The synthetic curcuminoid BHMC restores endotoxin-stimulated HUVEC dysfunction: specific disruption on enzymatic activity of p38 MAPK

QR Code

The synthetic curcuminoid BHMC restores endotoxin-stimulated HUVEC dysfunction: specific disruption on enzymatic activity of p38 MAPK

2,6-bis-(4-hydroxyl-3-methoxybenzylidine)cyclohexanone (BHMC) has been proven to selectively inhibit the synthesis of proinflammatory mediators in lipopolysaccharide-induced U937 monocytes through specific interruption of p38 Mitogen-Activated Protein Kinase enzymatic activity and improves the survi...

Full description

Bibliographic Details
Main Authors:	Chau, Ling Tham, Harith, Hanis Hazeera, Kok, Wai Lam, Yi, Joong Chong, Cheema, Manraj Singh, Sulaiman, Mohd Roslan, Lajis, Nordin, Ahmad Israf, Daud
Format:	Article
Language:	English
Published:	Elsevier 2015
Online Access:	http://psasir.upm.edu.my/id/eprint/46706/ http://psasir.upm.edu.my/id/eprint/46706/1/The%20synthetic%20curcuminoid%20BHMC%20restores%20endotoxin-stimulated%20HUVEC%20dysfunction%20specific%20disruption%20on%20enzymatic%20activity%20of%20p38%20MAPK.pdf

Similar Items

Use of the curcumin analog BHMC in the treatment of endothelial dysfunction and related disorders
by: Israf Ali, Daud Ahmad, et al.
Published: (2012)

A synthetic curcuminoid analogue, 2,6-Bis-4-(Hydroxyl-3-Methoxybenzylidine)-Cyclohexanone (BHMC) ameliorates acute airway inflammation of allergic asthma in ovalbumin-sensitized mice
by: Tham, Chau Ling, et al.
Published: (2021)

Atrovirinone inhibits proinflammatory mediator synthesis through disruption of NF-kappaB nuclear translocation and MAPK phosphorylation in the murine monocytic macrophage RAW 264.7.
by: Israf Ali, Daud Ahmad, et al.
Published: (2010)

The molecular targets and anti-invasive effects of 2,6-bis-(4-hydroxyl-3methoxybenzylidine) cyclohexanone or BHMC in MDA-MB-231 human breast cancer cells
by: Harun, Siti Nor Aini, et al.
Published: (2018)

Development of nanoparticles for targeted delivery of p38 MAPK inhibitor to myeloid dendritic cells
by: You, Jinge
Published: (2024)

Differential regulation of LPS-mediated VE-cadherin disruption in human endothelial cells and the underlying signaling pathways: a mini review
by: Chan, Yee Han, et al.
Published: (2020)

Development and validation of a bioanalytical method for quantification of 2,6-bis-(4-hydroxy-3-methoxybenzylidene)-cyclohexanone (BHMC) in rat plasma
by: Lee, Yu Zhao, et al.
Published: (2012)

Synergistic effects of GSK3 and p38 MAPK inhibitors on growth of Plasmodium falciparum ex vivo
by: Marhalim, L., et al.
Published: (2014)

A synthetic curcuminoid derivative inhibits nitric oxide and proinflammatory cytokine synthesis
by: Tham, Chau Ling, et al.
Published: (2010)

Suppression of PGE2 production via disruption of MAPK phosphorylation by unsymmetrical dicarbonyl curcumin derivatives
by: Mohd Aluwi, Mohd Fadhlizil Fasihi, et al.
Published: (2017)

Suppression of PGE2 production via disruption of MAPK phosphorylation by unsymmetrical dicarbonyl curcumin derivatives
by: Aluwi, Mohd Fadhlizil Fasihi Mohd, et al.
Published: (2017)

Anti-Food allergic activity of sulfated polysaccharide from Gracilaria lemaneiformisis dependent in immunosuppression and inhibition of p38 MAPK
by: Liu, Qing-Mei, et al.
Published: (2016)

Inhibition of the p38 MAPK pathway in human CD1c+ Dendritic Cells enhances their function for cancer immunotherapy
by: Kaur, Aanchal Preet
Published: (2021)

Inhibition of the p38 MAPK pathway as a strategy to overcome tumour immune suppression in CD1c+ dendritic cells
by: Chisanga, Chrispin
Published: (2024)

Thymoquinone inhibits tumor growth and induces apoptosis in a breast cancer xenograft mouse model: The role of p38 MAPK and ROS
by: Woo, C., et al.
Published: (2013)

The protective effects of a synthetic geranyl acetophenone in a cellular model of TNF-α-induced pulmonary epithelial barrier dysfunction
by: Tee, Yee Sim, et al.
Published: (2018)

Cellular iron depletion stimulates the JNK and p38 MAPK signaling transduction pathways, dissociation of ASK1-thioredoxin, and activation of ASK1
by: Yu, Yu, et al.
Published: (2011)

The geranyl acetophenone tHGA attenuates human bronchial smooth muscle proliferation via inhibition of AKT phosphorylation
by: Yap, Hui Min, et al.
Published: (2018)

The effects of a synthetic curcuminoid analogue,2,6-bis-(4-hydroxyl-3-methoxybenzylidine)cyclohexanone on proinflammatorysignaling pathways and CLP-induced lethal sepsis in mice.
by: Chau, Ling Tham, et al.
Published: (2011)

Cissus quadrangularis inhibits IL -1β induced inflammatory responses on chondrocytes and alleviates bone deterioration in osteotomized rats via p38 MAPK signaling
by: Kanwar, Jagat R, et al.
Published: (2015)

Anti-angiogenic effect of Ardisia crispa root in human umbilical vein endothelial cells (HUVECS)
by: Lim, Wen Jun, et al.
Published: (2015)

Human renal carcinoma cells respond to Newcastle disease virus infection through activation of the p38 MAPK/NF-κB/IκBα pathway
by: Ch'ng, Wei Choong, et al.
Published: (2015)

Removal of endotoxins from plasmid DNA: Analysis of aggregative interaction of mobile divalent metal cations with endotoxins and plasmid DNA
by: Ongkudon, C., et al.
Published: (2012)

Varying magnesium concentration elicits changes in inflammatory response in human umbilical vein endothelial cells (HUVECs)
by: Almousa, Lujain A., et al.
Published: (2018)

Experimental review on the Substance P-enhanced endothelial permeability in human umbilical vein endothelial cells (HUVECS)
by: N. N. H., Khairudin, et al.
Published: (2017)

The effects of curcuminoids on musculoskeletal pain: a systematic review.
by: Gaffey, A., et al.
Published: (2017)

Drug repurposing of clinically approved drugs to target epithelial-mesenchymal transition using molecular docking approach
by: Chun Hao, Ong, et al.
Published: (2023)

TGF-β-induced fibrosis: a review on the underlying mechanism and potential therapeutic strategies
by: Ong, Chun Hao, et al.
Published: (2021)

Nitric oxide inhibitory activity and antioxidant evaluations of 2-benzoyl-6-benzylidenecyclohexanone analogs, a novel series of curcuminoid and diarylpentanoid derivatives
by: Leong, Sze Wei, et al.
Published: (2015)

Complex Coacervated Microcapsules In Cream For Topical Delivery Of The Curcuminoids And Quercetin
by: Ang , Lee Fung
Published: (2015)

Endotoxin induced muscle wasting in avian and murine skeletal muscle
by: Tarabees, Reda Zakaria Ibrahim
Published: (2011)

Endo sensor bacterial endotoxin detector in liquid biological samples
by: John, Akbar, et al.
Published: (2011)

In vitro and in vivo antioxidant studies of curcuminoids extract and fractions / Noorhaslina Hashim
by: Hashim, Noorhaslina
Published: (2011)

Chromaticity Investigation Of Curcuminoid Dye Composite For White Light Down-Conversion
by: Al Shafouri, Mahmood Shaikhan Ta’eeb
Published: (2020)

A phloroglucinol from Melicope ptelefolia preserves barrier integrity of lipopolysaccharide-induced endothelial cells: study on junctional proteins and cytoskeleton remodeling
by: Chong, Yi Joong, et al.
Published: (2015)

Acquisition of aseptic techniques using virtual reality: a randomized trial on performance, emotion and experience
by: Chau Ling, Tham, et al.
Published: (2024)

Student acceptance towards AsepticTech VR: a teaching and learning tool for cell and tissue culture aseptic techniques
by: Cheng Wei, Lim, et al.
Published: (2024)

Methods for bacterial endotoxin quantification in reference to horseshoe crab blood studies
by: B, Akbar John, et al.
Published: (2011)

TAL - a source of bacterial endotoxin detector in liquid biological samples
by: John, Akbar, et al.
Published: (2012)

Endotoxin removal and plasmid DNA recovery in various metal ion solutions
by: Ongkudon, C., et al.
Published: (2011)