The effect of environmental chemicals on the tumor microenvironment
Potentially carcinogenic compounds may cause cancer through direct DNA damage or through indirect cellular or physiological effects. To study possible carcinogens, the fields of endocrinology, genetics, epigenetics, medicine, environmental health, toxicology, pharmacology and oncology must be consid...
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Oxford University Press
2015
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/46554/ http://psasir.upm.edu.my/id/eprint/46554/1/The%20effect%20of%20environmental%20chemicals%20on%20the%20tumor%20microenvironment.pdf |
| _version_ | 1848850685599154176 |
|---|---|
| author | Casey, Stephanie C. Vaccari, Monica Al-Mulla, Fahd Al-Temaimi, Rabeah Amedei, Amedeo Barcellos-Hoff, Mary Helen Brown, Dustin G. Chapellier, Marion Christopher, Joseph A. Curran, Colleen S. Forte, Stefano Abd Hamid, Roslida Heneberg, Petr Koch, Daniel C. Krishnakumar, P. K. |
| author_facet | Casey, Stephanie C. Vaccari, Monica Al-Mulla, Fahd Al-Temaimi, Rabeah Amedei, Amedeo Barcellos-Hoff, Mary Helen Brown, Dustin G. Chapellier, Marion Christopher, Joseph A. Curran, Colleen S. Forte, Stefano Abd Hamid, Roslida Heneberg, Petr Koch, Daniel C. Krishnakumar, P. K. |
| author_sort | Casey, Stephanie C. |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Potentially carcinogenic compounds may cause cancer through direct DNA damage or through indirect cellular or physiological effects. To study possible carcinogens, the fields of endocrinology, genetics, epigenetics, medicine, environmental health, toxicology, pharmacology and oncology must be considered. Disruptive chemicals may also contribute to multiple stages of tumor development through effects on the tumor microenvironment. In turn, the tumor microenvironment consists of a complex interaction among blood vessels that feed the tumor, the extracellular matrix that provides structural and biochemical support, signaling molecules that send messages and soluble factors such as cytokines. The tumor microenvironment also consists of many host cellular effectors including multipotent stromal cells/mesenchymal stem cells, fibroblasts, endothelial cell precursors, antigen-presenting cells, lymphocytes and innate immune cells. Carcinogens can influence the tumor microenvironment through effects on epithelial cells, the most common origin of cancer, as well as on stromal cells, extracellular matrix components and immune cells. Here, we review how environmental exposures can perturb the tumor microenvironment. We suggest a role for disrupting chemicals such as nickel chloride, Bisphenol A, butyltins, methylmercury and paraquat as well as more traditional carcinogens, such as radiation, and pharmaceuticals, such as diabetes medications, in the disruption of the tumor microenvironment. Further studies interrogating the role of chemicals and their mixtures in dose-dependent effects on the tumor microenvironment could have important general mechanistic implications for the etiology and prevention of tumorigenesis. |
| first_indexed | 2025-11-15T10:10:13Z |
| format | Article |
| id | upm-46554 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T10:10:13Z |
| publishDate | 2015 |
| publisher | Oxford University Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-465542022-06-20T06:52:12Z http://psasir.upm.edu.my/id/eprint/46554/ The effect of environmental chemicals on the tumor microenvironment Casey, Stephanie C. Vaccari, Monica Al-Mulla, Fahd Al-Temaimi, Rabeah Amedei, Amedeo Barcellos-Hoff, Mary Helen Brown, Dustin G. Chapellier, Marion Christopher, Joseph A. Curran, Colleen S. Forte, Stefano Abd Hamid, Roslida Heneberg, Petr Koch, Daniel C. Krishnakumar, P. K. Potentially carcinogenic compounds may cause cancer through direct DNA damage or through indirect cellular or physiological effects. To study possible carcinogens, the fields of endocrinology, genetics, epigenetics, medicine, environmental health, toxicology, pharmacology and oncology must be considered. Disruptive chemicals may also contribute to multiple stages of tumor development through effects on the tumor microenvironment. In turn, the tumor microenvironment consists of a complex interaction among blood vessels that feed the tumor, the extracellular matrix that provides structural and biochemical support, signaling molecules that send messages and soluble factors such as cytokines. The tumor microenvironment also consists of many host cellular effectors including multipotent stromal cells/mesenchymal stem cells, fibroblasts, endothelial cell precursors, antigen-presenting cells, lymphocytes and innate immune cells. Carcinogens can influence the tumor microenvironment through effects on epithelial cells, the most common origin of cancer, as well as on stromal cells, extracellular matrix components and immune cells. Here, we review how environmental exposures can perturb the tumor microenvironment. We suggest a role for disrupting chemicals such as nickel chloride, Bisphenol A, butyltins, methylmercury and paraquat as well as more traditional carcinogens, such as radiation, and pharmaceuticals, such as diabetes medications, in the disruption of the tumor microenvironment. Further studies interrogating the role of chemicals and their mixtures in dose-dependent effects on the tumor microenvironment could have important general mechanistic implications for the etiology and prevention of tumorigenesis. Oxford University Press 2015 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/46554/1/The%20effect%20of%20environmental%20chemicals%20on%20the%20tumor%20microenvironment.pdf Casey, Stephanie C. and Vaccari, Monica and Al-Mulla, Fahd and Al-Temaimi, Rabeah and Amedei, Amedeo and Barcellos-Hoff, Mary Helen and Brown, Dustin G. and Chapellier, Marion and Christopher, Joseph A. and Curran, Colleen S. and Forte, Stefano and Abd Hamid, Roslida and Heneberg, Petr and Koch, Daniel C. and Krishnakumar, P. K. (2015) The effect of environmental chemicals on the tumor microenvironment. Carcinogenesis, 36 (suppl. 1). S160-S183. ISSN 0143-3334; ESSN: 1460-2180 https://academic.oup.com/carcin/article/36/Suppl_1/S160/315417 10.1093/carcin/bgv035 |
| spellingShingle | Casey, Stephanie C. Vaccari, Monica Al-Mulla, Fahd Al-Temaimi, Rabeah Amedei, Amedeo Barcellos-Hoff, Mary Helen Brown, Dustin G. Chapellier, Marion Christopher, Joseph A. Curran, Colleen S. Forte, Stefano Abd Hamid, Roslida Heneberg, Petr Koch, Daniel C. Krishnakumar, P. K. The effect of environmental chemicals on the tumor microenvironment |
| title | The effect of environmental chemicals on the tumor microenvironment |
| title_full | The effect of environmental chemicals on the tumor microenvironment |
| title_fullStr | The effect of environmental chemicals on the tumor microenvironment |
| title_full_unstemmed | The effect of environmental chemicals on the tumor microenvironment |
| title_short | The effect of environmental chemicals on the tumor microenvironment |
| title_sort | effect of environmental chemicals on the tumor microenvironment |
| url | http://psasir.upm.edu.my/id/eprint/46554/ http://psasir.upm.edu.my/id/eprint/46554/ http://psasir.upm.edu.my/id/eprint/46554/ http://psasir.upm.edu.my/id/eprint/46554/1/The%20effect%20of%20environmental%20chemicals%20on%20the%20tumor%20microenvironment.pdf |