The curcumin analogue 1,5-bis(2-hydroxyphenyl)-1,4-pentadiene-3-one induces apoptosis and downregulates E6 and E7 oncogene expression in HPV16 and HPV18-infected cervical cancer cells

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The curcumin analogue 1,5-bis(2-hydroxyphenyl)-1,4-pentadiene-3-one induces apoptosis and downregulates E6 and E7 oncogene expression in HPV16 and HPV18-infected cervical cancer cells

In an effort to study curcumin analogues as an alternative to improve the therapeutic efficacy of curcumin, we screened the cytotoxic potential of four diarylpentanoids using the HeLa and CaSki cervical cancer cell lines. Determination of their EC50 values indicated relatively higher potency of 1,5-...

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Bibliographic Details
Main Authors:	Paulraj, Felicia, Abas, Faridah, Lajis, Nordin, Othman, Iekhsan, Syed Hassan, Sharifah, Naidu, Rakesh
Format:	Article
Language:	English
Published:	MDPI 2015
Online Access:	http://psasir.upm.edu.my/id/eprint/46538/ http://psasir.upm.edu.my/id/eprint/46538/1/The%20curcumin%20analogue%201%2C5-bis%282-hydroxyphenyl%29-1%2C4-pentadiene-3-one%20induces%20apoptosis%20and%20downregulates%20E6%20and%20E7%20oncogene%20expression%20in%20HPV16%20and%20HPV18-infected%20cervical%20cancer%20cells.pdf

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