Tetraprenyltoluquinone, an anticancer compound from Garcinia cowa Roxb induce cell cycle arrest on H460 non small lung cancer cell line
Tetraprenyltoluquinone (TPTQ), isolated compound from stem bark of Garcinia cowa Roxb showed selective cytotoxicity towards H460 lung cancer cell line. We further investigated the ability of this compound in inducing cell cycle arrest by flow cytometry. Cell cycle analysis revealed that TPTQ caused...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Global Research Online Publishing House
2015
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/46511/ http://psasir.upm.edu.my/id/eprint/46511/1/Tetraprenyltoluquinone%2C%20an%20anticancer%20compound%20from%20Garcinia%20cowa%20Roxb%20induce%20cell%20cycle%20arrest%20on%20h460%20non%20small%20lung%20cancer%20cell%20line_New.pdf |
| _version_ | 1848850675400704000 |
|---|---|
| author | Wahyuni, Fatma Sri Lim, Siang Hui Stanslas, Johnson Lajis, Nordin Hamidi, Dachriyanus |
| author_facet | Wahyuni, Fatma Sri Lim, Siang Hui Stanslas, Johnson Lajis, Nordin Hamidi, Dachriyanus |
| author_sort | Wahyuni, Fatma Sri |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Tetraprenyltoluquinone (TPTQ), isolated compound from stem bark of Garcinia cowa Roxb showed selective cytotoxicity towards H460 lung cancer cell line. We further investigated the ability of this compound in inducing cell cycle arrest by flow cytometry. Cell cycle analysis revealed that TPTQ caused cell cycle arrest in G0/G1 phase. Our results indicate that TPTQ induces cell cycle arrest and apoptosis in H-460 cells, suggesting that it might represent a potential new chemotherapeutic agent. |
| first_indexed | 2025-11-15T10:10:03Z |
| format | Article |
| id | upm-46511 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T10:10:03Z |
| publishDate | 2015 |
| publisher | Global Research Online Publishing House |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-465112022-06-20T03:48:47Z http://psasir.upm.edu.my/id/eprint/46511/ Tetraprenyltoluquinone, an anticancer compound from Garcinia cowa Roxb induce cell cycle arrest on H460 non small lung cancer cell line Wahyuni, Fatma Sri Lim, Siang Hui Stanslas, Johnson Lajis, Nordin Hamidi, Dachriyanus Tetraprenyltoluquinone (TPTQ), isolated compound from stem bark of Garcinia cowa Roxb showed selective cytotoxicity towards H460 lung cancer cell line. We further investigated the ability of this compound in inducing cell cycle arrest by flow cytometry. Cell cycle analysis revealed that TPTQ caused cell cycle arrest in G0/G1 phase. Our results indicate that TPTQ induces cell cycle arrest and apoptosis in H-460 cells, suggesting that it might represent a potential new chemotherapeutic agent. Global Research Online Publishing House 2015 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/46511/1/Tetraprenyltoluquinone%2C%20an%20anticancer%20compound%20from%20Garcinia%20cowa%20Roxb%20induce%20cell%20cycle%20arrest%20on%20h460%20non%20small%20lung%20cancer%20cell%20line_New.pdf Wahyuni, Fatma Sri and Lim, Siang Hui and Stanslas, Johnson and Lajis, Nordin and Hamidi, Dachriyanus (2015) Tetraprenyltoluquinone, an anticancer compound from Garcinia cowa Roxb induce cell cycle arrest on H460 non small lung cancer cell line. International Journal of Pharmaceutical Sciences Review and Research, 32 (2). art. no. 27. pp. 166-168. ISSN 0976-044X https://www.globalresearchonline.net/pharmajournal/vol32iss2.aspx |
| spellingShingle | Wahyuni, Fatma Sri Lim, Siang Hui Stanslas, Johnson Lajis, Nordin Hamidi, Dachriyanus Tetraprenyltoluquinone, an anticancer compound from Garcinia cowa Roxb induce cell cycle arrest on H460 non small lung cancer cell line |
| title | Tetraprenyltoluquinone, an anticancer compound from Garcinia cowa Roxb induce cell cycle arrest on H460 non small lung cancer cell line |
| title_full | Tetraprenyltoluquinone, an anticancer compound from Garcinia cowa Roxb induce cell cycle arrest on H460 non small lung cancer cell line |
| title_fullStr | Tetraprenyltoluquinone, an anticancer compound from Garcinia cowa Roxb induce cell cycle arrest on H460 non small lung cancer cell line |
| title_full_unstemmed | Tetraprenyltoluquinone, an anticancer compound from Garcinia cowa Roxb induce cell cycle arrest on H460 non small lung cancer cell line |
| title_short | Tetraprenyltoluquinone, an anticancer compound from Garcinia cowa Roxb induce cell cycle arrest on H460 non small lung cancer cell line |
| title_sort | tetraprenyltoluquinone, an anticancer compound from garcinia cowa roxb induce cell cycle arrest on h460 non small lung cancer cell line |
| url | http://psasir.upm.edu.my/id/eprint/46511/ http://psasir.upm.edu.my/id/eprint/46511/ http://psasir.upm.edu.my/id/eprint/46511/1/Tetraprenyltoluquinone%2C%20an%20anticancer%20compound%20from%20Garcinia%20cowa%20Roxb%20induce%20cell%20cycle%20arrest%20on%20h460%20non%20small%20lung%20cancer%20cell%20line_New.pdf |