Synthesis, characterization and biological evaluation of transition metal complexes derived from N, S bidentate ligands
Two bidentate NS ligands were synthesized by the condensation reaction of S-2-methylbenzyldithiocarbazate (S2MBDTC) with 2-methoxybenzaldehyde (2MB) and 3-methoxybenzaldehyde (3MB). The ligands were reacted separately with acetates of Cu(II), Ni(II) and Zn(II) yielding 1:2 (metal:ligand) complexes....
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI
2015
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| Online Access: | http://psasir.upm.edu.my/id/eprint/46478/ http://psasir.upm.edu.my/id/eprint/46478/1/Synthesis%2C%20characterization%20and%20biological%20evaluation%20of%20transition%20metal%20complexes%20derived%20from%20N%2C%20S%20bidentate%20ligands.pdf |
| _version_ | 1848850668663603200 |
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| author | Md Yusof, Enis Nadia Ravoof, Thahira Begum S. A. Tiekink, Edward R. T. Veerakumarasivam, Abhimanyu Crouse, Karen Anne Mohamed Tahir, Mohamed Ibrahim Ahmad, Haslina |
| author_facet | Md Yusof, Enis Nadia Ravoof, Thahira Begum S. A. Tiekink, Edward R. T. Veerakumarasivam, Abhimanyu Crouse, Karen Anne Mohamed Tahir, Mohamed Ibrahim Ahmad, Haslina |
| author_sort | Md Yusof, Enis Nadia |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Two bidentate NS ligands were synthesized by the condensation reaction of S-2-methylbenzyldithiocarbazate (S2MBDTC) with 2-methoxybenzaldehyde (2MB) and 3-methoxybenzaldehyde (3MB). The ligands were reacted separately with acetates of Cu(II), Ni(II) and Zn(II) yielding 1:2 (metal:ligand) complexes. The metal complexes formed were expected to have a general formula of [M(NS)2] where M = Cu2+, Ni2+, and Zn2+. These compounds were characterized by elemental analysis, molar conductivity, magnetic susceptibility and various spectroscopic techniques. The magnetic susceptibility measurements and spectral results supported the predicted coordination geometry in which the Schiff bases behaved as bidentate NS donor ligands coordinating via the azomethine nitrogen and thiolate sulfur. The molecular structures of the isomeric S2M2MBH (1) and S2M3MBH (2) were established by X-ray crystallography to have very similar l-shaped structures. The Schiff bases and their metal complexes were evaluated for their biological activities against estrogen receptor-positive (MCF-7) and estrogen receptor-negative (MDA-MB-231) breast cancer cell lines. Only the Cu(II) complexes showed marked cytotoxicity against the cancer cell lines. Both Schiff bases and other metal complexes were found to be inactive. In concordance with the cytotoxicity studies, the DNA binding studies indicated that Cu(II) complexes have a strong DNA binding affinity. |
| first_indexed | 2025-11-15T10:09:57Z |
| format | Article |
| id | upm-46478 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T10:09:57Z |
| publishDate | 2015 |
| publisher | MDPI |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-464782018-02-27T03:29:07Z http://psasir.upm.edu.my/id/eprint/46478/ Synthesis, characterization and biological evaluation of transition metal complexes derived from N, S bidentate ligands Md Yusof, Enis Nadia Ravoof, Thahira Begum S. A. Tiekink, Edward R. T. Veerakumarasivam, Abhimanyu Crouse, Karen Anne Mohamed Tahir, Mohamed Ibrahim Ahmad, Haslina Two bidentate NS ligands were synthesized by the condensation reaction of S-2-methylbenzyldithiocarbazate (S2MBDTC) with 2-methoxybenzaldehyde (2MB) and 3-methoxybenzaldehyde (3MB). The ligands were reacted separately with acetates of Cu(II), Ni(II) and Zn(II) yielding 1:2 (metal:ligand) complexes. The metal complexes formed were expected to have a general formula of [M(NS)2] where M = Cu2+, Ni2+, and Zn2+. These compounds were characterized by elemental analysis, molar conductivity, magnetic susceptibility and various spectroscopic techniques. The magnetic susceptibility measurements and spectral results supported the predicted coordination geometry in which the Schiff bases behaved as bidentate NS donor ligands coordinating via the azomethine nitrogen and thiolate sulfur. The molecular structures of the isomeric S2M2MBH (1) and S2M3MBH (2) were established by X-ray crystallography to have very similar l-shaped structures. The Schiff bases and their metal complexes were evaluated for their biological activities against estrogen receptor-positive (MCF-7) and estrogen receptor-negative (MDA-MB-231) breast cancer cell lines. Only the Cu(II) complexes showed marked cytotoxicity against the cancer cell lines. Both Schiff bases and other metal complexes were found to be inactive. In concordance with the cytotoxicity studies, the DNA binding studies indicated that Cu(II) complexes have a strong DNA binding affinity. MDPI 2015 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/46478/1/Synthesis%2C%20characterization%20and%20biological%20evaluation%20of%20transition%20metal%20complexes%20derived%20from%20N%2C%20S%20bidentate%20ligands.pdf Md Yusof, Enis Nadia and Ravoof, Thahira Begum S. A. and Tiekink, Edward R. T. and Veerakumarasivam, Abhimanyu and Crouse, Karen Anne and Mohamed Tahir, Mohamed Ibrahim and Ahmad, Haslina (2015) Synthesis, characterization and biological evaluation of transition metal complexes derived from N, S bidentate ligands. International Journal of Molecular Sciences, 16 (5). pp. 11034-11054. ISSN 1661-6596; ESSN:1422-0067 http://www.mdpi.com/journal/ijms 10.3390/ijms160511034 |
| spellingShingle | Md Yusof, Enis Nadia Ravoof, Thahira Begum S. A. Tiekink, Edward R. T. Veerakumarasivam, Abhimanyu Crouse, Karen Anne Mohamed Tahir, Mohamed Ibrahim Ahmad, Haslina Synthesis, characterization and biological evaluation of transition metal complexes derived from N, S bidentate ligands |
| title | Synthesis, characterization and biological evaluation of transition metal complexes derived from N, S bidentate ligands |
| title_full | Synthesis, characterization and biological evaluation of transition metal complexes derived from N, S bidentate ligands |
| title_fullStr | Synthesis, characterization and biological evaluation of transition metal complexes derived from N, S bidentate ligands |
| title_full_unstemmed | Synthesis, characterization and biological evaluation of transition metal complexes derived from N, S bidentate ligands |
| title_short | Synthesis, characterization and biological evaluation of transition metal complexes derived from N, S bidentate ligands |
| title_sort | synthesis, characterization and biological evaluation of transition metal complexes derived from n, s bidentate ligands |
| url | http://psasir.upm.edu.my/id/eprint/46478/ http://psasir.upm.edu.my/id/eprint/46478/ http://psasir.upm.edu.my/id/eprint/46478/ http://psasir.upm.edu.my/id/eprint/46478/1/Synthesis%2C%20characterization%20and%20biological%20evaluation%20of%20transition%20metal%20complexes%20derived%20from%20N%2C%20S%20bidentate%20ligands.pdf |