Synthesis, biological evaluation and QSAR studies of diarylpentanoid analogues as potential nitric oxide inhibitors

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Synthesis, biological evaluation and QSAR studies of diarylpentanoid analogues as potential nitric oxide inhibitors

A series of forty-five 1,5-diphenylpenta-2,4-dien-1-one analogues were synthesized and evaluated for their nitric oxide (NO) inhibition activity in IFN-γ/LPS-activated RAW 264.7 cells. Compounds 3h, 7a, 7d and 7e exhibited comparable or significantly higher activity than the standard, curcumin (IC50...

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Bibliographic Details
Main Authors:	Mohd Faudzi, S. M., Leong, S. W., Abas, F., Mohd Aluwi, M. F. F., Rullah, K., Lam, K. W., Ahmad, S., Tham, C. L., Shaari, K., Lajis, N. H.
Format:	Article
Language:	English
Published:	Royal Society of Chemistry 2015
Online Access:	http://psasir.upm.edu.my/id/eprint/46477/ http://psasir.upm.edu.my/id/eprint/46477/1/Synthesis%2C%20biological%20evaluation%20and%20QSAR%20studies%20of%20diarylpentanoid%20analogues%20as%20potential%20nitric%20oxide%20inhibitors.pdf

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