Synthesis of a DNA-targeting nickel (II) complex with testosterone thiosemicarbazone which exhibits selective cytotoxicity towards human prostate cancer cells (LNCaP)

QR Code

Synthesis of a DNA-targeting nickel (II) complex with testosterone thiosemicarbazone which exhibits selective cytotoxicity towards human prostate cancer cells (LNCaP)

Testosterone thiosemicarbazone, L and its nickel (II) complex 1 were synthesized and characterized by using FTIR, CHN, (1)H NMR, and X-ray crystallography. X-ray diffraction study confirmed the formation of L from condensation of testosterone and thiosemicarbazide. Mononuclear complex 1 is coordinat...

Full description

Bibliographic Details
Main Authors:	Mok, Piew Heng, Sinniah, Saravana Kumar, Wuen, Yew Teoh, Kae, Shin Sim, Seik, Weng Ng, Cheah, Yoke Kqueen, Kong, Wai Tan
Format:	Article
Language:	English
Published:	Elsevier 2015
Online Access:	http://psasir.upm.edu.my/id/eprint/46466/ http://psasir.upm.edu.my/id/eprint/46466/1/Synthesis%20of%20a%20DNA-targeting%20nickel%20%28II%29%20complex%20with%20testosterone%20thiosemicarbazone%20which%20exhibits%20selective%20cytotoxicity%20towards%20human%20prostate%20cancer%20cells%20%28LNCaP%29.pdf

Similar Items

Synthesis, characterization, and biological properties of nickel (II) complexes with derivatives of testosterone thiosemicarbazone
by: Heng, Mok Piew
Published: (2015)

Synthesis, cytotoxicity and apoptosis studies on nickel and zinc derivatives of testosterone-N4-substituted-thiosemicarbazones / Heng Mok Piew
by: Heng , Mok Piew
Published: (2020)

Characterisation of alternative splice variants of PIP5K1A in the human metastatic prostate cancer cell line, LNCaP C4-2
by: Roberts, Christopher / C.J.
Published: (2022)

In vivo assessment of the therapeutic effects of lyophilized leech saliva extract from (Huridinaria manillensis) on LNCaP tumor xenograft model in nude mice
by: Ammar, Amr, et al.
Published: (2015)

Cytotoxic activities, apoptotic induction and mitochondrial studies of selected cationic schiff bases from the thiosemicarbazone family / Saravana Kumar Sinniah
by: Saravana Kumar , Sinniah
Published: (2016)

Inhibitory effects of Pueraria mirifica aqueous extracts on 5α-reductase and prostate histomorphometry in testosterone induced benign prostatic hyperplasia Sprague Dawley rats
by: Masrudin, Siti Saleha, et al.
Published: (2023)

Attenuation of testosterone-induced benign prostatic hyperplasia with Andrographis paniculata (burm.f.) leaf extract in Wistar rats
by: Etti, Imaobong Christopher, et al.
Published: (2024)

(E)-4-(Benzyloxy)Benzaldehyde Thiosemicarbazone
by: Tarafder, Md. Tofazzal Hossain, et al.
Published: (2008)

Evaluation of antioxidant properties, cytotoxicity and acute oral toxicity of Gynura procumbens (Compositae)
by: Wuen, Yew Teoh, et al.
Published: (2016)

The potent and novel thiosemicarbazone chelators Di-2-pyridylketone-4,4- dimethyl-3-thiosemicarbazone and 2-benzoylpyridine-4,4-dimethyl-3- thiosemicarbazone affect crucial thiol systems required for ribonucleotide reductase activity
by: Yu, Yu, et al.
Published: (2011)

Coordination chemistry of organotin(IV) complexes with substitute thiosemicarbazone ligands
by: Adibah Amirah, Binti Abdul Nasir
Published: (2012)

Bioactivities of Gynura spp. and phytochemical investigations of Gynura Bicolor / Teoh Wuen Yew
by: Teoh, Wuen Yew
Published: (2016)

Study of bacterial diversity in the oral cavity of Malaysian subjects / Teoh Wuen Yew
by: Teoh, Wuen Yew
Published: (2010)

Tuberculosis of the prostate presenting as benign prostatic hyperplasia.
by: Fazarina M,, et al.
Published: (2013)

Synthesis and biological studies of nickel(II) complexes of thiosemicarbazones / S Savina Savir
by: S Savina , Savir
Published: (2021)

Thiosemicarbazone Iron Chelator: Evaluation of the anti-cancer activity and mechanisms of action
by: Yu, W., et al.
Published: (2011)

The role of gonadotropins and testosterone in the regulation of beta amyloid metabolism
by: Verdile, Giuseppe, et al.
Published: (2009)

The Effects of Testosterone Supplementation on Cognitive Functioning in Older Men
by: Wahjoepramono, E., et al.
Published: (2016)

Determination of plasma levels of dehydroepiandrosterone sulphate and testosterone in the boar.
by: Raeside, J.I., et al.
Published: (1976)

Exhibiting on the Edge
by: Farren, Anne
Published: (2011)

Studies on the bioactive properties of selected plant and fermented extracts / Saravana Kumar Sinniah
by: Kumar Sinniah, Saravana
Published: (2010)

A study on survivin expression in prostate cancer and benign prostatic hyperplasia; and its association with pre-operative serum prostate specific antigen and gleason score in prostate cancer
by: Hadi, Normila Abdul
Published: (2016)

Effect of eurycoma longifolia on the testosterone level in adult male rats
by: Alfaqeh, Hamoud Hussein Mohammed, et al.
Published: (2018)

Kesan testosteron terhadap larva ascaris suum pada mencit
by: Rohani A. Ahmad,, et al.
Published: (1996)

Can testosterone replacement decrease the memory problem of old age?
by: Lim, David, et al.
Published: (2003)

Prediction of fetal sex in cattle by testosterone levels in allantoic fluid
by: Bongso, Tuan Ariffeen, et al.
Published: (1976)

Synthesis, characterization and biological properties of cyclic thiosemicarbazone zinc(II) complexes / Vikneswara Rajamuthy
by: Vikneswaran, Rajamuthy
Published: (2016)

Synthesis, characterization,reaction mechanism and theoreticalstudy of anntimicrobial inhibitor from heteroaromatics based thiosemicarbazone
by: Jori Roslan, Muhammad Qusyairi, et al.
Published: (2018)

Prostatic diseases: is it toxic or genetic? Study of TNF alpha gene polymorphism and cigarette smoking in cases of prostate cancer and benign prostatic hyperplasia
by: M. Attalla, Sohayla, et al.
Published: (2016)

Affect-based Exhibition
by: Harris, Jennifer
Published: (2016)

Development of exhibition cabinet
by: Mohd Afizan, A Ripin @ Ariffin
Published: (2007)

Inventive product exhibition
by: Wan Jumani, Fauzi
Published: (2009)

Which English?
by: McAlinden, Maggie, et al.
Published: (2013)

Which Indians?
by: The Star, Martin Vengadesan
Published: (2008)

Prenatal testosterone exposure is related to sexually dimorphic facial morphology in adulthood
by: Whitehouse, A., et al.
Published: (2015)

Serum testosterone levels correlate with haemoglobin in middle-aged and older men
by: Yeap, B., et al.
Published: (2009)

Distinct Effects of Testosterone on Plasma and Cerebrospinal Fluid Amyloid-ß Levels
by: Wahjoepramono, E., et al.
Published: (2008)

Development And Evaluation Of A Matrix Controlled Release Implant System For Testosterone
by: Hamad, Islam
Published: (2002)

The effect of noise stress on the serum testosterone level in spraque dwaley rats
by: Chandralekha, G.

The effect of noise stress on the serum testosterone level in spraque dawley rats
by: Chandralekha, G.
Published: (2005)