SRS06, a new semisynthetic andrographolide derivative with improved anticancer potency and selectivity, inhibits nuclear factor-kB nuclear binding in the A549 non-small cell lung cancer cell line

SRS06, a new semisynthetic andrographolide derivative with improved anticancer potency and selectivity, inhibits nuclear factor-kB nuclear binding in the A549 non-small cell lung cancer cell line

Background: Andrographolide has been reported with anticancer and anti-inflammatory properties through the inhibition of the activity of signaling molecules such as v-Src, nuclear factor-κB (NF-κB), STAT3, and PI3K. NF-κB has been proven to promote cancer cell survival, and targeting this pathway wi...

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Bibliographic Details
Main Authors: Lim, Jonathan Chee Woei, Jeyaraj, Ethel Jeyaseela, Sagineedu, Sreenivasa Rao, Wong, Wai Shiu Fred, Stanslas, Johnson
Format: Article
Language:English
Published: Karger Publishers 2015
Online Access:http://psasir.upm.edu.my/id/eprint/46370/
http://psasir.upm.edu.my/id/eprint/46370/1/SRS06%2C%20a%20new%20semisynthetic%20andrographolide%20derivative%20with%20improved%20anticancer%20potency%20and%20selectivity%2C%20inhibits%20nuclear%20factor-kB%20nuclear%20binding%20in%20the%20A549%20non-small%20cell%20lung%20cancer%20cell%20line.pdf

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