Solitary fibrous tumour of the chest wall
Extrapleural solitary fibrous tumours (SFTs) are rare tumours characterized by patternless spindle cells with haemangiopericytoma-like vascular spaces. Previously the tumours have been classified as haemangiopericytoma, an entity that is now considered obsolete. We report a case of extrapleural SFT...
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| Format: | Article |
| Language: | English |
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Malaysian Society of Pathologists
2016
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| Online Access: | http://psasir.upm.edu.my/id/eprint/46334/ http://psasir.upm.edu.my/id/eprint/46334/1/Solitary%20fibrous%20tumour%20of%20the%20chest%20wall.pdf |
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| author | Mohtarrudin, Norhafizah Nor Hanipah, Zubaidah Mohd Dusa, Noraini |
| author_facet | Mohtarrudin, Norhafizah Nor Hanipah, Zubaidah Mohd Dusa, Noraini |
| author_sort | Mohtarrudin, Norhafizah |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Extrapleural solitary fibrous tumours (SFTs) are rare tumours characterized by patternless spindle cells with haemangiopericytoma-like vascular spaces. Previously the tumours have been classified as haemangiopericytoma, an entity that is now considered obsolete. We report a case of extrapleural SFT arising in the soft tissue of the chest wall. The patient was a 31-year-old Malay lady presenting with a mobile swelling of the right chest wall for more than five years. During excision the tumour was noted to be well-circumscribed and yellowish in colour, giving an impression of lipoma. Microscopically, the tumour had patternless architecture, characterized by hypocellular and hypercellular areas. It was composed of uniform, spindle-shaped cells displaying oval nuclei, inconspicuous nucleoli, pale cytoplasm and indistinct cell borders. The mitotic count was 2 per 10 HPF. Branching, medium-sized thin-walled blood vessels in a haemangiopericytomatous growth pattern, some with hyalinised wall were identified. The neoplastic cells were immunoreactive to CD99 and CD34 and were non-immunoreactive to Desmin, Smooth Muscle Actin, S100 protein and EMA. We elucidate the challenges in diagnosing this tumour in this unusual location. |
| first_indexed | 2025-11-15T10:09:31Z |
| format | Article |
| id | upm-46334 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T10:09:31Z |
| publishDate | 2016 |
| publisher | Malaysian Society of Pathologists |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-463342022-06-17T08:06:18Z http://psasir.upm.edu.my/id/eprint/46334/ Solitary fibrous tumour of the chest wall Mohtarrudin, Norhafizah Nor Hanipah, Zubaidah Mohd Dusa, Noraini Extrapleural solitary fibrous tumours (SFTs) are rare tumours characterized by patternless spindle cells with haemangiopericytoma-like vascular spaces. Previously the tumours have been classified as haemangiopericytoma, an entity that is now considered obsolete. We report a case of extrapleural SFT arising in the soft tissue of the chest wall. The patient was a 31-year-old Malay lady presenting with a mobile swelling of the right chest wall for more than five years. During excision the tumour was noted to be well-circumscribed and yellowish in colour, giving an impression of lipoma. Microscopically, the tumour had patternless architecture, characterized by hypocellular and hypercellular areas. It was composed of uniform, spindle-shaped cells displaying oval nuclei, inconspicuous nucleoli, pale cytoplasm and indistinct cell borders. The mitotic count was 2 per 10 HPF. Branching, medium-sized thin-walled blood vessels in a haemangiopericytomatous growth pattern, some with hyalinised wall were identified. The neoplastic cells were immunoreactive to CD99 and CD34 and were non-immunoreactive to Desmin, Smooth Muscle Actin, S100 protein and EMA. We elucidate the challenges in diagnosing this tumour in this unusual location. Malaysian Society of Pathologists 2016-04 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/46334/1/Solitary%20fibrous%20tumour%20of%20the%20chest%20wall.pdf Mohtarrudin, Norhafizah and Nor Hanipah, Zubaidah and Mohd Dusa, Noraini (2016) Solitary fibrous tumour of the chest wall. Malaysian Journal of Pathology, 38 (1). pp. 61-64. ISSN 0126-8635 https://pubmed.ncbi.nlm.nih.gov/27126667/#:~:text=Abstract,that%20is%20now%20considered%20obsolete. |
| spellingShingle | Mohtarrudin, Norhafizah Nor Hanipah, Zubaidah Mohd Dusa, Noraini Solitary fibrous tumour of the chest wall |
| title | Solitary fibrous tumour of the chest wall |
| title_full | Solitary fibrous tumour of the chest wall |
| title_fullStr | Solitary fibrous tumour of the chest wall |
| title_full_unstemmed | Solitary fibrous tumour of the chest wall |
| title_short | Solitary fibrous tumour of the chest wall |
| title_sort | solitary fibrous tumour of the chest wall |
| url | http://psasir.upm.edu.my/id/eprint/46334/ http://psasir.upm.edu.my/id/eprint/46334/ http://psasir.upm.edu.my/id/eprint/46334/1/Solitary%20fibrous%20tumour%20of%20the%20chest%20wall.pdf |