Skin intervention of fullerene-integrated nanoemulsion in structural and collagen regeneration against skin aging
Despite the fact that intrinsic oxidative stress is inevitable, the extrinsic factor such as ultraviolet radiation enhances reactive oxygen species (ROS) generation resulting in premature skin aging. Nanoemulsion was loaded with fullerene, a strong free radical scavenger, and its efficacy to provide...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2015
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| Online Access: | http://psasir.upm.edu.my/id/eprint/46301/ http://psasir.upm.edu.my/id/eprint/46301/1/Skin%20intervention%20of%20fullerene-integrated%20nanoemulsion%20in%20structural%20and%20collagen%20regeneration%20against%20skin%20aging.pdf |
| _version_ | 1848850634075275264 |
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| author | Cheng, Loong Ngan Basri, Mahiran Tripathy, Minaketan Karjiban, Roghayeh Abedi Abd. Malek, Emilia |
| author_facet | Cheng, Loong Ngan Basri, Mahiran Tripathy, Minaketan Karjiban, Roghayeh Abedi Abd. Malek, Emilia |
| author_sort | Cheng, Loong Ngan |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Despite the fact that intrinsic oxidative stress is inevitable, the extrinsic factor such as ultraviolet radiation enhances reactive oxygen species (ROS) generation resulting in premature skin aging. Nanoemulsion was loaded with fullerene, a strong free radical scavenger, and its efficacy to provide protection and regenerative effect against ROS-induced collagen breakdown in human skin was studied. Stable fullerene nanoemulsions were formulated using high shear homogenization and ultrasonic dispersion technique. An open trial was conducted using fullerene nanoemulsion on skin twice a day for 28 days. The mean collagen score significantly increased (P<0.05) from 36.53±4.39 to 48.69±5.46 with 33.29% increment at the end of the treatment. Biophysical characteristics of skin revealed that skin hydration was increased significantly (P<0.05) from 40.91±7.01 to 58.55±6.08 corneometric units (43.12% increment) and the water was able to contain within the stratum corneum without any increased in transepidermal water loss. In the in vitro safety evaluation, fullerene nanoemulsion showed no acute toxicity on 3T3 fibroblast cell line for 48h and no indication of potential dermal irritation. Hence, the fullerene nanoemulsion may assist in protecting collagen from breakdown with cosmeceutical benefit. |
| first_indexed | 2025-11-15T10:09:24Z |
| format | Article |
| id | upm-46301 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T10:09:24Z |
| publishDate | 2015 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-463012022-06-17T04:09:24Z http://psasir.upm.edu.my/id/eprint/46301/ Skin intervention of fullerene-integrated nanoemulsion in structural and collagen regeneration against skin aging Cheng, Loong Ngan Basri, Mahiran Tripathy, Minaketan Karjiban, Roghayeh Abedi Abd. Malek, Emilia Despite the fact that intrinsic oxidative stress is inevitable, the extrinsic factor such as ultraviolet radiation enhances reactive oxygen species (ROS) generation resulting in premature skin aging. Nanoemulsion was loaded with fullerene, a strong free radical scavenger, and its efficacy to provide protection and regenerative effect against ROS-induced collagen breakdown in human skin was studied. Stable fullerene nanoemulsions were formulated using high shear homogenization and ultrasonic dispersion technique. An open trial was conducted using fullerene nanoemulsion on skin twice a day for 28 days. The mean collagen score significantly increased (P<0.05) from 36.53±4.39 to 48.69±5.46 with 33.29% increment at the end of the treatment. Biophysical characteristics of skin revealed that skin hydration was increased significantly (P<0.05) from 40.91±7.01 to 58.55±6.08 corneometric units (43.12% increment) and the water was able to contain within the stratum corneum without any increased in transepidermal water loss. In the in vitro safety evaluation, fullerene nanoemulsion showed no acute toxicity on 3T3 fibroblast cell line for 48h and no indication of potential dermal irritation. Hence, the fullerene nanoemulsion may assist in protecting collagen from breakdown with cosmeceutical benefit. Elsevier 2015-04 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/46301/1/Skin%20intervention%20of%20fullerene-integrated%20nanoemulsion%20in%20structural%20and%20collagen%20regeneration%20against%20skin%20aging.pdf Cheng, Loong Ngan and Basri, Mahiran and Tripathy, Minaketan and Karjiban, Roghayeh Abedi and Abd. Malek, Emilia (2015) Skin intervention of fullerene-integrated nanoemulsion in structural and collagen regeneration against skin aging. European Journal of Pharmaceutical Sciences, 70. pp. 22-28. ISSN 0928-0987; ESSN: 1879-0720 https://www.sciencedirect.com/science/article/pii/S092809871500024X?via%3Dihub 10.1016/j.ejps.2015.01.006 |
| spellingShingle | Cheng, Loong Ngan Basri, Mahiran Tripathy, Minaketan Karjiban, Roghayeh Abedi Abd. Malek, Emilia Skin intervention of fullerene-integrated nanoemulsion in structural and collagen regeneration against skin aging |
| title | Skin intervention of fullerene-integrated nanoemulsion in structural and collagen regeneration against skin aging |
| title_full | Skin intervention of fullerene-integrated nanoemulsion in structural and collagen regeneration against skin aging |
| title_fullStr | Skin intervention of fullerene-integrated nanoemulsion in structural and collagen regeneration against skin aging |
| title_full_unstemmed | Skin intervention of fullerene-integrated nanoemulsion in structural and collagen regeneration against skin aging |
| title_short | Skin intervention of fullerene-integrated nanoemulsion in structural and collagen regeneration against skin aging |
| title_sort | skin intervention of fullerene-integrated nanoemulsion in structural and collagen regeneration against skin aging |
| url | http://psasir.upm.edu.my/id/eprint/46301/ http://psasir.upm.edu.my/id/eprint/46301/ http://psasir.upm.edu.my/id/eprint/46301/ http://psasir.upm.edu.my/id/eprint/46301/1/Skin%20intervention%20of%20fullerene-integrated%20nanoemulsion%20in%20structural%20and%20collagen%20regeneration%20against%20skin%20aging.pdf |