Relationship between metabolites composition and biological activities of Phyllanthus niruri extracts prepared by different drying methods and solvents extraction
The study investigated the changes in the metabolite, antioxidant and α-glucosidase inhibitory activities of Phyllanthus niruri after three drying treatments: air, freeze and oven dryings. Water extracts and extracts obtained using different solvent ratios of ethanol and methanol (50, 70, 80 and 100...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Springer
2015
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/46130/ http://psasir.upm.edu.my/id/eprint/46130/1/Relationship%20between%20metabolites%20composition%20and%20biological%20activities%20of%20Phyllanthus%20niruri%20extracts%20prepared%20by%20different%20drying%20methods%20and%20solvents%20extraction.pdf |
| _version_ | 1848850600511406080 |
|---|---|
| author | Mediani, Ahmed Abas, Faridah Khatib, Alfi Tan, Chin Ping Ismail, Intan Safinar Shaari, Khozirah Ismail, Amin Lajis, N. H. |
| author_facet | Mediani, Ahmed Abas, Faridah Khatib, Alfi Tan, Chin Ping Ismail, Intan Safinar Shaari, Khozirah Ismail, Amin Lajis, N. H. |
| author_sort | Mediani, Ahmed |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | The study investigated the changes in the metabolite, antioxidant and α-glucosidase inhibitory activities of Phyllanthus niruri after three drying treatments: air, freeze and oven dryings. Water extracts and extracts obtained using different solvent ratios of ethanol and methanol (50, 70, 80 and 100%) were compared. The relationships among the antioxidant, α-glucosidase inhibitory activity and metabolite levels of the extracts were evaluated using partial least-square analysis (PLS). The solvent selectivity was assessed based on the phytochemical constituents present in the extract and their concentrations quantitatively analyzed using high performance liquid chromatography. The freeze-dried P. niruri samples that were extracted with the mixture of ethanol or methanol with low ratio of water showed higher biological activity values compared with the other extracts. The PLS results for the ethanolic with different ratio and water extracts demonstrated that phenolic acids (chlorogenic acid and ellagic acid) and flavonoids were highly linked to strong α-glucosidase inhibitory and antioxidant activities. |
| first_indexed | 2025-11-15T10:08:52Z |
| format | Article |
| id | upm-46130 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T10:08:52Z |
| publishDate | 2015 |
| publisher | Springer |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-461302022-03-23T04:03:04Z http://psasir.upm.edu.my/id/eprint/46130/ Relationship between metabolites composition and biological activities of Phyllanthus niruri extracts prepared by different drying methods and solvents extraction Mediani, Ahmed Abas, Faridah Khatib, Alfi Tan, Chin Ping Ismail, Intan Safinar Shaari, Khozirah Ismail, Amin Lajis, N. H. The study investigated the changes in the metabolite, antioxidant and α-glucosidase inhibitory activities of Phyllanthus niruri after three drying treatments: air, freeze and oven dryings. Water extracts and extracts obtained using different solvent ratios of ethanol and methanol (50, 70, 80 and 100%) were compared. The relationships among the antioxidant, α-glucosidase inhibitory activity and metabolite levels of the extracts were evaluated using partial least-square analysis (PLS). The solvent selectivity was assessed based on the phytochemical constituents present in the extract and their concentrations quantitatively analyzed using high performance liquid chromatography. The freeze-dried P. niruri samples that were extracted with the mixture of ethanol or methanol with low ratio of water showed higher biological activity values compared with the other extracts. The PLS results for the ethanolic with different ratio and water extracts demonstrated that phenolic acids (chlorogenic acid and ellagic acid) and flavonoids were highly linked to strong α-glucosidase inhibitory and antioxidant activities. Springer 2015 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/46130/1/Relationship%20between%20metabolites%20composition%20and%20biological%20activities%20of%20Phyllanthus%20niruri%20extracts%20prepared%20by%20different%20drying%20methods%20and%20solvents%20extraction.pdf Mediani, Ahmed and Abas, Faridah and Khatib, Alfi and Tan, Chin Ping and Ismail, Intan Safinar and Shaari, Khozirah and Ismail, Amin and Lajis, N. H. (2015) Relationship between metabolites composition and biological activities of Phyllanthus niruri extracts prepared by different drying methods and solvents extraction. Plant Foods For Human Nutrition, 70. pp. 184-192. ISSN 0921-9668; ESSN: 1573-9104 https://link.springer.com/article/10.1007%2Fs11130-015-0478-5 10.1007/s11130-015-0478-5 |
| spellingShingle | Mediani, Ahmed Abas, Faridah Khatib, Alfi Tan, Chin Ping Ismail, Intan Safinar Shaari, Khozirah Ismail, Amin Lajis, N. H. Relationship between metabolites composition and biological activities of Phyllanthus niruri extracts prepared by different drying methods and solvents extraction |
| title | Relationship between metabolites composition and biological activities of Phyllanthus niruri extracts prepared by different drying methods and solvents extraction |
| title_full | Relationship between metabolites composition and biological activities of Phyllanthus niruri extracts prepared by different drying methods and solvents extraction |
| title_fullStr | Relationship between metabolites composition and biological activities of Phyllanthus niruri extracts prepared by different drying methods and solvents extraction |
| title_full_unstemmed | Relationship between metabolites composition and biological activities of Phyllanthus niruri extracts prepared by different drying methods and solvents extraction |
| title_short | Relationship between metabolites composition and biological activities of Phyllanthus niruri extracts prepared by different drying methods and solvents extraction |
| title_sort | relationship between metabolites composition and biological activities of phyllanthus niruri extracts prepared by different drying methods and solvents extraction |
| url | http://psasir.upm.edu.my/id/eprint/46130/ http://psasir.upm.edu.my/id/eprint/46130/ http://psasir.upm.edu.my/id/eprint/46130/ http://psasir.upm.edu.my/id/eprint/46130/1/Relationship%20between%20metabolites%20composition%20and%20biological%20activities%20of%20Phyllanthus%20niruri%20extracts%20prepared%20by%20different%20drying%20methods%20and%20solvents%20extraction.pdf |