Primary mediastinal choriocarcinoma masquerading as lung metastasis: a rare disease with a fatal outcome
Background: Most germ cell tumors eg. choriocarcinomas are located in the gonads, however about 2–5% arise from extragonadal regions, such as the mediastinum, retroperitoneum, and central nervous system. Non-gestational choriocarcinoma in mediastinum without a detectable primary in the gonads is ter...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Community Health Society Malaysia
2015
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| Online Access: | http://psasir.upm.edu.my/id/eprint/46002/ http://psasir.upm.edu.my/id/eprint/46002/1/Primary%20mediastinal%20choriocarcinoma%20masquerading%20as%20lung%20metastasis%20a%20rare%20disease%20with%20a%20fatal%20outcome.pdf |
| _version_ | 1848850576299786240 |
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| author | D., Balakrishnan S., Suppiah S., Md Sidek O., Noriah |
| author_facet | D., Balakrishnan S., Suppiah S., Md Sidek O., Noriah |
| author_sort | D., Balakrishnan |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Background: Most germ cell tumors eg. choriocarcinomas are located in the gonads, however about 2–5% arise from extragonadal regions, such as the mediastinum, retroperitoneum, and central nervous system. Non-gestational choriocarcinoma in mediastinum without a detectable primary in the gonads is termed primary mediastinal choriocarcinoma. Materials and method: Contrast-enhanced whole body computed tomography scan and correlated with tumour markers such as beta human chorionic gonadotropin are used to assess the mediastinal mass. Confirmation of diagnosis was made with image guided biopsy, histopathological examination and special staining. Results: Primary mediastinal choriocarcinoma was confirmed by lack of testicular lesion on ultrasound examination and presence of mediastinal mass with multiple metastatic lesions. Confirmation by CKAE1/AE3 (immunohistochemical study) positive which showed presence of multinucleated epithelial cells. Conclusion: Contrast-enhanced computed tomography is useful tool to diagnose this condition as also provide image guided access for biopsy. In correlation with tumour markers investigation and special immunohistochemical studies can help to clinch the diagnosis. |
| first_indexed | 2025-11-15T10:08:29Z |
| format | Article |
| id | upm-46002 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T10:08:29Z |
| publishDate | 2015 |
| publisher | Community Health Society Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-460022022-03-30T03:37:29Z http://psasir.upm.edu.my/id/eprint/46002/ Primary mediastinal choriocarcinoma masquerading as lung metastasis: a rare disease with a fatal outcome D., Balakrishnan S., Suppiah S., Md Sidek O., Noriah Background: Most germ cell tumors eg. choriocarcinomas are located in the gonads, however about 2–5% arise from extragonadal regions, such as the mediastinum, retroperitoneum, and central nervous system. Non-gestational choriocarcinoma in mediastinum without a detectable primary in the gonads is termed primary mediastinal choriocarcinoma. Materials and method: Contrast-enhanced whole body computed tomography scan and correlated with tumour markers such as beta human chorionic gonadotropin are used to assess the mediastinal mass. Confirmation of diagnosis was made with image guided biopsy, histopathological examination and special staining. Results: Primary mediastinal choriocarcinoma was confirmed by lack of testicular lesion on ultrasound examination and presence of mediastinal mass with multiple metastatic lesions. Confirmation by CKAE1/AE3 (immunohistochemical study) positive which showed presence of multinucleated epithelial cells. Conclusion: Contrast-enhanced computed tomography is useful tool to diagnose this condition as also provide image guided access for biopsy. In correlation with tumour markers investigation and special immunohistochemical studies can help to clinch the diagnosis. Community Health Society Malaysia 2015 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/46002/1/Primary%20mediastinal%20choriocarcinoma%20masquerading%20as%20lung%20metastasis%20a%20rare%20disease%20with%20a%20fatal%20outcome.pdf D., Balakrishnan and S., Suppiah and S., Md Sidek and O., Noriah (2015) Primary mediastinal choriocarcinoma masquerading as lung metastasis: a rare disease with a fatal outcome. International Journal of Public Health and Clinical Sciences, 2 (6). pp. 132-140. ISSN 2289-7577 http://publichealthmy.org/ejournal/ojs2/index.php/ijphcs/article/view/251 |
| spellingShingle | D., Balakrishnan S., Suppiah S., Md Sidek O., Noriah Primary mediastinal choriocarcinoma masquerading as lung metastasis: a rare disease with a fatal outcome |
| title | Primary mediastinal choriocarcinoma masquerading as lung metastasis: a rare disease with a fatal outcome |
| title_full | Primary mediastinal choriocarcinoma masquerading as lung metastasis: a rare disease with a fatal outcome |
| title_fullStr | Primary mediastinal choriocarcinoma masquerading as lung metastasis: a rare disease with a fatal outcome |
| title_full_unstemmed | Primary mediastinal choriocarcinoma masquerading as lung metastasis: a rare disease with a fatal outcome |
| title_short | Primary mediastinal choriocarcinoma masquerading as lung metastasis: a rare disease with a fatal outcome |
| title_sort | primary mediastinal choriocarcinoma masquerading as lung metastasis: a rare disease with a fatal outcome |
| url | http://psasir.upm.edu.my/id/eprint/46002/ http://psasir.upm.edu.my/id/eprint/46002/ http://psasir.upm.edu.my/id/eprint/46002/1/Primary%20mediastinal%20choriocarcinoma%20masquerading%20as%20lung%20metastasis%20a%20rare%20disease%20with%20a%20fatal%20outcome.pdf |