Prevalence of the UGT1A1*6 (c.211G>A) polymorphism and irinotecan toxicity in Iranian populations of different ethnicities

Prevalence of the UGT1A1*6 (c.211G>A) polymorphism and irinotecan toxicity in Iranian populations of different ethnicities

Background: Pharmacogenetic studies on irinotecan treatment in patients with metastatic colorectal cancer have indicated that genetic polymorphisms in UGT1A1*6 can lead to decreased enzyme activity and accumulation of the toxic metabolite SN-38. Here, we compared the prevalence of UGT1A1*6 in an Ira...

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Bibliographic Details
Main Authors: Shakibi, Reyhaneh, Kamalidehghan, Behnam, Ahmadipour, Fatemeh, Meng, Goh Yong, Houshmand, Massoud
Format: Article
Language:English
Published: Karger Publishers 2015
Online Access:http://psasir.upm.edu.my/id/eprint/45994/
http://psasir.upm.edu.my/id/eprint/45994/1/Prevalence%20of%20the%20UGT1A16%20%28c.211GA%29%20polymorphism%20and%20irinotecan%20toxicity%20in%20Iranian%20populations%20of%20different%20ethnicities.pdf

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