Predictors of adherence behaviour among HIV positive patients receiving Antiretroviral Therapy (ART) in Malaysia
Introduction: Success of antiretroviral treatment depends on a host of factors, the most important of which is the patient’s adherence behaviour. The objective of this study was to determine whether the introduction of mobile phone technology (SMS and telephone call reminders) can significantly impr...
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| Format: | Article |
| Language: | English |
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Malaysian Medical Association
2015
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| Online Access: | http://psasir.upm.edu.my/id/eprint/45936/ http://psasir.upm.edu.my/id/eprint/45936/1/Predictors%20of%20adherence%20behaviour%20among%20HIV%20positive%20patients%20receiving%20Antiretroviral%20Therapy%20%28ART%29%20in%20Malaysia.pdf |
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| author | Abdulrahman, Surajudeen Abiola Rampal, Lekhraj Radhakrishnan, Anuradha P. Ibrahim, Faisal Othman, Norlijah Shahar, Hayati Kadir |
| author_facet | Abdulrahman, Surajudeen Abiola Rampal, Lekhraj Radhakrishnan, Anuradha P. Ibrahim, Faisal Othman, Norlijah Shahar, Hayati Kadir |
| author_sort | Abdulrahman, Surajudeen Abiola |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Introduction: Success of antiretroviral treatment depends on a host of factors, the most important of which is the patient’s adherence behaviour. The objective of this study was to determine whether the introduction of mobile phone technology (SMS and telephone call reminders) can significantly improve adherence and treatment outcomes among HIV positive patients on ART. This paper highlights ‘context-specific’ predictors of adherence behaviour among a cohort of Malaysian patients receiving ART. Methods: A single-blinded RCT was carried out in Hospital Sungai Buloh between January and December 2014 among HIV positive patients on ART. Data on socio-demographic factors, clinical symptoms, and adherence behaviour, assessed using the modified and pre-validated Adult AIDS Clinic Trials Group adherence questionnaires were collected. CD4 count, viral load, weight, full blood count, blood pressure, liver function and renal profile tests were also conducted and recorded. Multivariate regression models were used to examine the relationship between study variables using SPSS version 21 and R software. Results: The overall mean age of 242 respondents was 33.4 (standard deviation (SD) 9.2, range 18-64) years. Majority (88.8%) were males. Overall, 47.9% of respondents were placed on ZDV/3TC/EFV regimen, 47.1% took TDF/FTC/EFV regimen at baseline (ART initiation) while other HAART regimens accounted for only 5% of the distribution altogether. Univariate logistic regression analysis showed that adherence behaviour was significantly associated with ethnicity, monthly income and employment status. After controlling for the effect of age and treatment group, multivariate multinomial logistic regression analysis showed that patient’s employment status (adjusted Odds Ratio 4.46; 95% CI: 3.22, 6.18) was a significant predictor of adherence behaviour among HIV positive patients receiving ART in Malaysia. Conclusion: The findings provide additional support to the growing body of evidence on the strong relationship between patient’s employment status and their adherence behaviour, particularly in concentrated epidemics and low-to-middle income economies. |
| first_indexed | 2025-11-15T10:08:17Z |
| format | Article |
| id | upm-45936 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T10:08:17Z |
| publishDate | 2015 |
| publisher | Malaysian Medical Association |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-459362022-05-19T04:37:25Z http://psasir.upm.edu.my/id/eprint/45936/ Predictors of adherence behaviour among HIV positive patients receiving Antiretroviral Therapy (ART) in Malaysia Abdulrahman, Surajudeen Abiola Rampal, Lekhraj Radhakrishnan, Anuradha P. Ibrahim, Faisal Othman, Norlijah Shahar, Hayati Kadir Introduction: Success of antiretroviral treatment depends on a host of factors, the most important of which is the patient’s adherence behaviour. The objective of this study was to determine whether the introduction of mobile phone technology (SMS and telephone call reminders) can significantly improve adherence and treatment outcomes among HIV positive patients on ART. This paper highlights ‘context-specific’ predictors of adherence behaviour among a cohort of Malaysian patients receiving ART. Methods: A single-blinded RCT was carried out in Hospital Sungai Buloh between January and December 2014 among HIV positive patients on ART. Data on socio-demographic factors, clinical symptoms, and adherence behaviour, assessed using the modified and pre-validated Adult AIDS Clinic Trials Group adherence questionnaires were collected. CD4 count, viral load, weight, full blood count, blood pressure, liver function and renal profile tests were also conducted and recorded. Multivariate regression models were used to examine the relationship between study variables using SPSS version 21 and R software. Results: The overall mean age of 242 respondents was 33.4 (standard deviation (SD) 9.2, range 18-64) years. Majority (88.8%) were males. Overall, 47.9% of respondents were placed on ZDV/3TC/EFV regimen, 47.1% took TDF/FTC/EFV regimen at baseline (ART initiation) while other HAART regimens accounted for only 5% of the distribution altogether. Univariate logistic regression analysis showed that adherence behaviour was significantly associated with ethnicity, monthly income and employment status. After controlling for the effect of age and treatment group, multivariate multinomial logistic regression analysis showed that patient’s employment status (adjusted Odds Ratio 4.46; 95% CI: 3.22, 6.18) was a significant predictor of adherence behaviour among HIV positive patients receiving ART in Malaysia. Conclusion: The findings provide additional support to the growing body of evidence on the strong relationship between patient’s employment status and their adherence behaviour, particularly in concentrated epidemics and low-to-middle income economies. Malaysian Medical Association 2015 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/45936/1/Predictors%20of%20adherence%20behaviour%20among%20HIV%20positive%20patients%20receiving%20Antiretroviral%20Therapy%20%28ART%29%20in%20Malaysia.pdf Abdulrahman, Surajudeen Abiola and Rampal, Lekhraj and Radhakrishnan, Anuradha P. and Ibrahim, Faisal and Othman, Norlijah and Shahar, Hayati Kadir (2015) Predictors of adherence behaviour among HIV positive patients receiving Antiretroviral Therapy (ART) in Malaysia. Medical Journal of Malaysia, 70 (suppl.1). p. 29. ISSN 0300-5283 http://www.e-mjm.org/2015/v70s1/mjm-sept-suppl-2116.html |
| spellingShingle | Abdulrahman, Surajudeen Abiola Rampal, Lekhraj Radhakrishnan, Anuradha P. Ibrahim, Faisal Othman, Norlijah Shahar, Hayati Kadir Predictors of adherence behaviour among HIV positive patients receiving Antiretroviral Therapy (ART) in Malaysia |
| title | Predictors of adherence behaviour among HIV positive patients receiving Antiretroviral Therapy (ART) in Malaysia |
| title_full | Predictors of adherence behaviour among HIV positive patients receiving Antiretroviral Therapy (ART) in Malaysia |
| title_fullStr | Predictors of adherence behaviour among HIV positive patients receiving Antiretroviral Therapy (ART) in Malaysia |
| title_full_unstemmed | Predictors of adherence behaviour among HIV positive patients receiving Antiretroviral Therapy (ART) in Malaysia |
| title_short | Predictors of adherence behaviour among HIV positive patients receiving Antiretroviral Therapy (ART) in Malaysia |
| title_sort | predictors of adherence behaviour among hiv positive patients receiving antiretroviral therapy (art) in malaysia |
| url | http://psasir.upm.edu.my/id/eprint/45936/ http://psasir.upm.edu.my/id/eprint/45936/ http://psasir.upm.edu.my/id/eprint/45936/1/Predictors%20of%20adherence%20behaviour%20among%20HIV%20positive%20patients%20receiving%20Antiretroviral%20Therapy%20%28ART%29%20in%20Malaysia.pdf |