Physical cues of cell culture materials lead the direction of differentiation lineages of pluripotent stem cells
Both human pluripotent stem cells (hPSCs) from embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSCs) have the potential ability to differentiate into many different cell types originating from all three germ layers. This review discusses physical cues from natural and synthetic bi...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Royal Society of Chemistry
2015
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| Online Access: | http://psasir.upm.edu.my/id/eprint/45850/ http://psasir.upm.edu.my/id/eprint/45850/1/CELL.pdf |
| _version_ | 1848850547685195776 |
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| author | Higuchi, Akon Ling, Qing Dong Kumar, S. Suresh Yung, Chang Alarfaj, Abdullah A. Munusamy, Murugan A. Murugan, Kadarkarai Hsu, Shih Tien Umezawa, Akihiro |
| author_facet | Higuchi, Akon Ling, Qing Dong Kumar, S. Suresh Yung, Chang Alarfaj, Abdullah A. Munusamy, Murugan A. Murugan, Kadarkarai Hsu, Shih Tien Umezawa, Akihiro |
| author_sort | Higuchi, Akon |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Both human pluripotent stem cells (hPSCs) from embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSCs) have the potential ability to differentiate into many different cell types originating from all three germ layers. This review discusses physical cues from natural and synthetic biomaterials that guide the differentiation of hESCs and hiPSCs into several different lineages. We place special focus on how the hPSC differentiation fate is affected by (a) the elasticity of biomaterials used for hPSC culture, (b) the topography of biomaterials used for hPSC culture, and (c) the mechanical forces associated with biomaterials (stretching and electrical stimulation via biomaterials) used for hPSC culture. |
| first_indexed | 2025-11-15T10:08:02Z |
| format | Article |
| id | upm-45850 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T10:08:02Z |
| publishDate | 2015 |
| publisher | Royal Society of Chemistry |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-458502021-05-06T00:00:49Z http://psasir.upm.edu.my/id/eprint/45850/ Physical cues of cell culture materials lead the direction of differentiation lineages of pluripotent stem cells Higuchi, Akon Ling, Qing Dong Kumar, S. Suresh Yung, Chang Alarfaj, Abdullah A. Munusamy, Murugan A. Murugan, Kadarkarai Hsu, Shih Tien Umezawa, Akihiro Both human pluripotent stem cells (hPSCs) from embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSCs) have the potential ability to differentiate into many different cell types originating from all three germ layers. This review discusses physical cues from natural and synthetic biomaterials that guide the differentiation of hESCs and hiPSCs into several different lineages. We place special focus on how the hPSC differentiation fate is affected by (a) the elasticity of biomaterials used for hPSC culture, (b) the topography of biomaterials used for hPSC culture, and (c) the mechanical forces associated with biomaterials (stretching and electrical stimulation via biomaterials) used for hPSC culture. Royal Society of Chemistry 2015 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/45850/1/CELL.pdf Higuchi, Akon and Ling, Qing Dong and Kumar, S. Suresh and Yung, Chang and Alarfaj, Abdullah A. and Munusamy, Murugan A. and Murugan, Kadarkarai and Hsu, Shih Tien and Umezawa, Akihiro (2015) Physical cues of cell culture materials lead the direction of differentiation lineages of pluripotent stem cells. Journal of Materials Chemistry B: Materials for biology and medicine, 3 (41). pp. 8032-8058. ISSN 2050-750X; ESSN: 2050-7518 https://pubs.rsc.org/en/content/articlelanding/2015/tb/c5tb01276g#!divAbstract 10.1039/c5tb01276g |
| spellingShingle | Higuchi, Akon Ling, Qing Dong Kumar, S. Suresh Yung, Chang Alarfaj, Abdullah A. Munusamy, Murugan A. Murugan, Kadarkarai Hsu, Shih Tien Umezawa, Akihiro Physical cues of cell culture materials lead the direction of differentiation lineages of pluripotent stem cells |
| title | Physical cues of cell culture materials lead the direction of differentiation lineages of pluripotent stem cells |
| title_full | Physical cues of cell culture materials lead the direction of differentiation lineages of pluripotent stem cells |
| title_fullStr | Physical cues of cell culture materials lead the direction of differentiation lineages of pluripotent stem cells |
| title_full_unstemmed | Physical cues of cell culture materials lead the direction of differentiation lineages of pluripotent stem cells |
| title_short | Physical cues of cell culture materials lead the direction of differentiation lineages of pluripotent stem cells |
| title_sort | physical cues of cell culture materials lead the direction of differentiation lineages of pluripotent stem cells |
| url | http://psasir.upm.edu.my/id/eprint/45850/ http://psasir.upm.edu.my/id/eprint/45850/ http://psasir.upm.edu.my/id/eprint/45850/ http://psasir.upm.edu.my/id/eprint/45850/1/CELL.pdf |