Observation of risk factors, clinical manifestations and genetic characterization of recent Newcastle disease virus outbreak in West Malaysia
Background: Newcastle disease virus remains a constant threat in commercial poultry farms despite intensive vaccination programs. Outbreaks attributed to ND can escalate and spread across farms and states contributing to major economic loss in poultry farms. Results: Phylogenetic analysis in our stu...
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| Format: | Article |
| Language: | English |
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BioMed Central
2015
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| Online Access: | http://psasir.upm.edu.my/id/eprint/45640/ http://psasir.upm.edu.my/id/eprint/45640/1/VIRUS.pdf |
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| author | Ooi, Peck Toung Phang, Lai Yee Allaudin, Zeenathul Nazariah Yip, Lai Siong Choo, Pow Yoon Lim, Ban Keong Lemiere, Stephane Audonnet, Christophe Jaganathan, Seetha |
| author_facet | Ooi, Peck Toung Phang, Lai Yee Allaudin, Zeenathul Nazariah Yip, Lai Siong Choo, Pow Yoon Lim, Ban Keong Lemiere, Stephane Audonnet, Christophe Jaganathan, Seetha |
| author_sort | Ooi, Peck Toung |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Background: Newcastle disease virus remains a constant threat in commercial poultry farms despite intensive vaccination programs. Outbreaks attributed to ND can escalate and spread across farms and states contributing to major economic loss in poultry farms. Results: Phylogenetic analysis in our study showed that eleven of the samples belonged to genotype VIId. All farms were concurrently positive with two immunosuppressive viruses; Infectious Bursal Disease Virus (IBDV) and Marek’s Disease Virus (MDV). Amino acid sequence analysis confirmed that eleven of the samples had sequence motifs for velogenic/mesogenic strains; three were lentogenic. Conclusion: In conclusion, no new NDV genotype was isolated from the 2011 NDV outbreak. This study suggests that the presence of other immunosuppressive agents such as IBD and MDV could have contributed to the dysfunction of the immune system of the chickens, causing severe NDV outbreaks in 2011. Risk factors related to biosecurity and farm practices appear to have a significant role in the severity of the disease observed in affected farms. |
| first_indexed | 2025-11-15T10:07:41Z |
| format | Article |
| id | upm-45640 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T10:07:41Z |
| publishDate | 2015 |
| publisher | BioMed Central |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-456402021-01-23T22:43:34Z http://psasir.upm.edu.my/id/eprint/45640/ Observation of risk factors, clinical manifestations and genetic characterization of recent Newcastle disease virus outbreak in West Malaysia Ooi, Peck Toung Phang, Lai Yee Allaudin, Zeenathul Nazariah Yip, Lai Siong Choo, Pow Yoon Lim, Ban Keong Lemiere, Stephane Audonnet, Christophe Jaganathan, Seetha Background: Newcastle disease virus remains a constant threat in commercial poultry farms despite intensive vaccination programs. Outbreaks attributed to ND can escalate and spread across farms and states contributing to major economic loss in poultry farms. Results: Phylogenetic analysis in our study showed that eleven of the samples belonged to genotype VIId. All farms were concurrently positive with two immunosuppressive viruses; Infectious Bursal Disease Virus (IBDV) and Marek’s Disease Virus (MDV). Amino acid sequence analysis confirmed that eleven of the samples had sequence motifs for velogenic/mesogenic strains; three were lentogenic. Conclusion: In conclusion, no new NDV genotype was isolated from the 2011 NDV outbreak. This study suggests that the presence of other immunosuppressive agents such as IBD and MDV could have contributed to the dysfunction of the immune system of the chickens, causing severe NDV outbreaks in 2011. Risk factors related to biosecurity and farm practices appear to have a significant role in the severity of the disease observed in affected farms. BioMed Central 2015 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/45640/1/VIRUS.pdf Ooi, Peck Toung and Phang, Lai Yee and Allaudin, Zeenathul Nazariah and Yip, Lai Siong and Choo, Pow Yoon and Lim, Ban Keong and Lemiere, Stephane and Audonnet, Christophe and Jaganathan, Seetha (2015) Observation of risk factors, clinical manifestations and genetic characterization of recent Newcastle disease virus outbreak in West Malaysia. BMC veterinary research, 11 (219). pp. 1-9. ISSN 1746-6148 https://bmcvetres.biomedcentral.com/articles/10.1186/s12917-015-0537-z 10.1186/s12917-015-0537-z |
| spellingShingle | Ooi, Peck Toung Phang, Lai Yee Allaudin, Zeenathul Nazariah Yip, Lai Siong Choo, Pow Yoon Lim, Ban Keong Lemiere, Stephane Audonnet, Christophe Jaganathan, Seetha Observation of risk factors, clinical manifestations and genetic characterization of recent Newcastle disease virus outbreak in West Malaysia |
| title | Observation of risk factors, clinical manifestations and genetic characterization of recent Newcastle disease virus outbreak in West Malaysia |
| title_full | Observation of risk factors, clinical manifestations and genetic characterization of recent Newcastle disease virus outbreak in West Malaysia |
| title_fullStr | Observation of risk factors, clinical manifestations and genetic characterization of recent Newcastle disease virus outbreak in West Malaysia |
| title_full_unstemmed | Observation of risk factors, clinical manifestations and genetic characterization of recent Newcastle disease virus outbreak in West Malaysia |
| title_short | Observation of risk factors, clinical manifestations and genetic characterization of recent Newcastle disease virus outbreak in West Malaysia |
| title_sort | observation of risk factors, clinical manifestations and genetic characterization of recent newcastle disease virus outbreak in west malaysia |
| url | http://psasir.upm.edu.my/id/eprint/45640/ http://psasir.upm.edu.my/id/eprint/45640/ http://psasir.upm.edu.my/id/eprint/45640/ http://psasir.upm.edu.my/id/eprint/45640/1/VIRUS.pdf |