Nigella sativa fixed and essential oil improves antioxidant status through modulation of antioxidant enzymes and immunity
The onset of 21st century witnessed the awareness among the masses regarding the diet-health linkages. The researchers attempted to explore traditional products/plants were in the domain of pharmacy and nutrition focussing on their health benefits. In the present research intervention, we investigat...
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| Format: | Article |
| Language: | English |
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Pakistan Journal of Pharmaceutical Sciences
2015
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| Online Access: | http://psasir.upm.edu.my/id/eprint/45598/ http://psasir.upm.edu.my/id/eprint/45598/1/SATIVA.pdf |
| _version_ | 1848850521300926464 |
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| author | Karim, Roselina Sultan, Muhammad Tauseef Butt, Masood Sadiq Ahmad, Atif Nisar Ahmad, Rabia Shabbir Ahmad, Waqas |
| author_facet | Karim, Roselina Sultan, Muhammad Tauseef Butt, Masood Sadiq Ahmad, Atif Nisar Ahmad, Rabia Shabbir Ahmad, Waqas |
| author_sort | Karim, Roselina |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | The onset of 21st century witnessed the awareness among the masses regarding the diet-health linkages. The researchers attempted to explore traditional products/plants were in the domain of pharmacy and nutrition focussing on their health benefits. In the present research intervention, we investigate the role of Nigella sativa fixed oil (NSFO) and essential oil (NSEO) in improving antioxidant status and modulation of enzymes. The National Institute of Health (NIH) provided us 30 Sprague Dawley rats that were equally placed in three groups. The groups were fed on their respective diets (56 days) two experimental diets i.e. D2 (NSFO @ 4.0%) and D3 (NSEO @ 0.30%) and control. The indices pertaining to antioxidant status, antioxidant enzymes, and parameters pertaining to immunity were evaluated at 4 weeks interval. The experimental diets (NSFO@ 4.0% & NSEO@ 0.30%) modulated the activities of antioxidant enzymes i.e., catalase (CAT), superoxide dismutase (SOD), glutathione transferase (GST), glutathione reductase (GR) and glutathione peroxidase (GPx), positively. Indices of antioxidant status like tocopherols and glutathione were in linear relationship with that of GPx, GR and GST (P<0.01). Myeloperoxidase activities were in negative correlation with GST (P<0.01) but positive correlation with some other parameters. In the nutshell, the fixed and essential oil of Nigella sativa are effective in improving the indices pertaining to antioxidant status, however, the immune boosting potential needs further clarification. However, authors are of the view that there is need to explore the molecular targets of Nigella sativa fixed and essential oils. Findings from such studies would be useful to validate this instant study for health promoting potential against diabetes mellitus and cardiovascular disorders. |
| first_indexed | 2025-11-15T10:07:36Z |
| format | Article |
| id | upm-45598 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T10:07:36Z |
| publishDate | 2015 |
| publisher | Pakistan Journal of Pharmaceutical Sciences |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-455982021-01-26T19:29:10Z http://psasir.upm.edu.my/id/eprint/45598/ Nigella sativa fixed and essential oil improves antioxidant status through modulation of antioxidant enzymes and immunity Karim, Roselina Sultan, Muhammad Tauseef Butt, Masood Sadiq Ahmad, Atif Nisar Ahmad, Rabia Shabbir Ahmad, Waqas The onset of 21st century witnessed the awareness among the masses regarding the diet-health linkages. The researchers attempted to explore traditional products/plants were in the domain of pharmacy and nutrition focussing on their health benefits. In the present research intervention, we investigate the role of Nigella sativa fixed oil (NSFO) and essential oil (NSEO) in improving antioxidant status and modulation of enzymes. The National Institute of Health (NIH) provided us 30 Sprague Dawley rats that were equally placed in three groups. The groups were fed on their respective diets (56 days) two experimental diets i.e. D2 (NSFO @ 4.0%) and D3 (NSEO @ 0.30%) and control. The indices pertaining to antioxidant status, antioxidant enzymes, and parameters pertaining to immunity were evaluated at 4 weeks interval. The experimental diets (NSFO@ 4.0% & NSEO@ 0.30%) modulated the activities of antioxidant enzymes i.e., catalase (CAT), superoxide dismutase (SOD), glutathione transferase (GST), glutathione reductase (GR) and glutathione peroxidase (GPx), positively. Indices of antioxidant status like tocopherols and glutathione were in linear relationship with that of GPx, GR and GST (P<0.01). Myeloperoxidase activities were in negative correlation with GST (P<0.01) but positive correlation with some other parameters. In the nutshell, the fixed and essential oil of Nigella sativa are effective in improving the indices pertaining to antioxidant status, however, the immune boosting potential needs further clarification. However, authors are of the view that there is need to explore the molecular targets of Nigella sativa fixed and essential oils. Findings from such studies would be useful to validate this instant study for health promoting potential against diabetes mellitus and cardiovascular disorders. Pakistan Journal of Pharmaceutical Sciences 2015 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/45598/1/SATIVA.pdf Karim, Roselina and Sultan, Muhammad Tauseef and Butt, Masood Sadiq and Ahmad, Atif Nisar and Ahmad, Rabia Shabbir and Ahmad, Waqas (2015) Nigella sativa fixed and essential oil improves antioxidant status through modulation of antioxidant enzymes and immunity. Pakistan Journal of Pharmaceutical Sciences, 28 (2). pp. 589-595. ISSN 1011-601X |
| spellingShingle | Karim, Roselina Sultan, Muhammad Tauseef Butt, Masood Sadiq Ahmad, Atif Nisar Ahmad, Rabia Shabbir Ahmad, Waqas Nigella sativa fixed and essential oil improves antioxidant status through modulation of antioxidant enzymes and immunity |
| title | Nigella sativa fixed and essential oil improves antioxidant status through modulation of antioxidant enzymes and immunity |
| title_full | Nigella sativa fixed and essential oil improves antioxidant status through modulation of antioxidant enzymes and immunity |
| title_fullStr | Nigella sativa fixed and essential oil improves antioxidant status through modulation of antioxidant enzymes and immunity |
| title_full_unstemmed | Nigella sativa fixed and essential oil improves antioxidant status through modulation of antioxidant enzymes and immunity |
| title_short | Nigella sativa fixed and essential oil improves antioxidant status through modulation of antioxidant enzymes and immunity |
| title_sort | nigella sativa fixed and essential oil improves antioxidant status through modulation of antioxidant enzymes and immunity |
| url | http://psasir.upm.edu.my/id/eprint/45598/ http://psasir.upm.edu.my/id/eprint/45598/1/SATIVA.pdf |