Formulation and evaluation of galantamine gel as drug reservoir in transdermal patch delivery system
Galantamine hydrobromide is formulated in tablets and capsules prescribed through oral delivery for the treatment of Alzheimer’s disease. However, oral delivery of drugs can cause severe side effects such as nausea, vomiting, and gastrointestinal disturbance. Transdermal delivery of galantamine hy...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Hindawi
2015
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| Online Access: | http://psasir.upm.edu.my/id/eprint/44846/ http://psasir.upm.edu.my/id/eprint/44846/1/Formulation%20and%20evaluation%20of%20galantamine%20gel%20as%20drug%20reservoir%20in%20transdermal%20patch%20delivery%20system%20.pdf |
| _version_ | 1848850463975276544 |
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| author | Woo, Fong Yen Basri, Mahiran Ahmad, Mansor Ismail, Maznah |
| author_facet | Woo, Fong Yen Basri, Mahiran Ahmad, Mansor Ismail, Maznah |
| author_sort | Woo, Fong Yen |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Galantamine hydrobromide is formulated in tablets and capsules prescribed through oral delivery for the treatment of
Alzheimer’s disease. However, oral delivery of drugs can cause severe side effects such as nausea, vomiting, and gastrointestinal
disturbance. Transdermal delivery of galantamine hydrobromide could avoid these unwanted side effects. In this work, galantamine
hydrobromide was formulated in gel drug reservoir which was then fabricated in the transdermal patch. The in vitro drug release
studies revealed that the drug release from the donor chamber to receptor chamber of Franz diffusion cell was affected by the
amount of polymer, amount of neutralizer, amount of drug, types of permeation enhancer, and amount of permeation enhancer.
Visual observations of the gels showed that all formulated gels are translucent, homogeneous, smooth, and stable. These gels have
pH in the suitable range for skin. The gel also showed high drug content uniformity. Hence, this formulation can be further used
in the preparation of transdermal patch drug delivery system. |
| first_indexed | 2025-11-15T10:06:42Z |
| format | Article |
| id | upm-44846 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T10:06:42Z |
| publishDate | 2015 |
| publisher | Hindawi |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-448462021-04-20T05:47:41Z http://psasir.upm.edu.my/id/eprint/44846/ Formulation and evaluation of galantamine gel as drug reservoir in transdermal patch delivery system Woo, Fong Yen Basri, Mahiran Ahmad, Mansor Ismail, Maznah Galantamine hydrobromide is formulated in tablets and capsules prescribed through oral delivery for the treatment of Alzheimer’s disease. However, oral delivery of drugs can cause severe side effects such as nausea, vomiting, and gastrointestinal disturbance. Transdermal delivery of galantamine hydrobromide could avoid these unwanted side effects. In this work, galantamine hydrobromide was formulated in gel drug reservoir which was then fabricated in the transdermal patch. The in vitro drug release studies revealed that the drug release from the donor chamber to receptor chamber of Franz diffusion cell was affected by the amount of polymer, amount of neutralizer, amount of drug, types of permeation enhancer, and amount of permeation enhancer. Visual observations of the gels showed that all formulated gels are translucent, homogeneous, smooth, and stable. These gels have pH in the suitable range for skin. The gel also showed high drug content uniformity. Hence, this formulation can be further used in the preparation of transdermal patch drug delivery system. Hindawi 2015 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/44846/1/Formulation%20and%20evaluation%20of%20galantamine%20gel%20as%20drug%20reservoir%20in%20transdermal%20patch%20delivery%20system%20.pdf Woo, Fong Yen and Basri, Mahiran and Ahmad, Mansor and Ismail, Maznah (2015) Formulation and evaluation of galantamine gel as drug reservoir in transdermal patch delivery system. Scientific World Journal, 2015. art. no. 49527. pp. 1-7. ISSN 2356-6140; ESSN: 1537-744X https://www.hindawi.com/journals/tswj/2015/495271/ 10.1155/2015/495271 |
| spellingShingle | Woo, Fong Yen Basri, Mahiran Ahmad, Mansor Ismail, Maznah Formulation and evaluation of galantamine gel as drug reservoir in transdermal patch delivery system |
| title | Formulation and evaluation of galantamine gel as drug reservoir in transdermal patch delivery system |
| title_full | Formulation and evaluation of galantamine gel as drug reservoir in transdermal patch delivery system |
| title_fullStr | Formulation and evaluation of galantamine gel as drug reservoir in transdermal patch delivery system |
| title_full_unstemmed | Formulation and evaluation of galantamine gel as drug reservoir in transdermal patch delivery system |
| title_short | Formulation and evaluation of galantamine gel as drug reservoir in transdermal patch delivery system |
| title_sort | formulation and evaluation of galantamine gel as drug reservoir in transdermal patch delivery system |
| url | http://psasir.upm.edu.my/id/eprint/44846/ http://psasir.upm.edu.my/id/eprint/44846/ http://psasir.upm.edu.my/id/eprint/44846/ http://psasir.upm.edu.my/id/eprint/44846/1/Formulation%20and%20evaluation%20of%20galantamine%20gel%20as%20drug%20reservoir%20in%20transdermal%20patch%20delivery%20system%20.pdf |