Evaluation of osteogenic potentials of avian demineralized bone matrix in the healing of osseous defects in pigeons
Objectives: To evaluate avian allogeneic demineralized bone matrix (DBM) in the healing of long bone defects as a function of geometry and time in a pigeon model. Study design: Experimental. Animals: Adult rock pigeons (n = 60). Methods: Midshaft ulnar osseous defects were grafted with 2 geometri...
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| Format: | Article |
| Language: | English |
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Wiley
2015
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| Online Access: | http://psasir.upm.edu.my/id/eprint/44693/ http://psasir.upm.edu.my/id/eprint/44693/1/Evaluation%20of%20osteogenic%20potentials%20of%20avian%20demineralized%20bone%20matrix%20in%20the%20healing%20of%20osseous%20defects%20in%20pigeons.pdf |
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| author | Sanaei, Reza Abu, Jalila Nazari, Mojgan Abu Bakar @ Zakaria, Md Zuki Allaudin, Zeenathul Nazariah |
| author_facet | Sanaei, Reza Abu, Jalila Nazari, Mojgan Abu Bakar @ Zakaria, Md Zuki Allaudin, Zeenathul Nazariah |
| author_sort | Sanaei, Reza |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Objectives: To evaluate avian allogeneic demineralized bone matrix (DBM) in the healing of long bone defects as a function of geometry and time in a pigeon model.
Study design: Experimental.
Animals: Adult rock pigeons (n = 60).
Methods: Midshaft ulnar osseous defects were grafted with 2 geometric forms of DBM (tubular vs. chipped) and stabilized with a hybrid fixator. Autologous chips of sternal keel were used in a third group as control. Outcomes were evaluated by radiography and histology/histomorphometry at 4, 8, 12, and 24 weeks postoperatively.
Results: Despite an early rapid healing response, autografts plateaued (histologic score and new bone area) by 8 weeks with no significant improvement afterwards. Conversely, allogeneic DBM implants demonstrated continuous temporal improvement in bone healing, and tubular DBM finally outpaced autograft implants after week 12 with values for metrics achieving statistical significance by week 24. Chip DBM was inferior to tubular DBM and autograft.
Conclusions: Avian DBM is osteogenic, biocompatible, and safe in orthotopic sites with potential usefulness in avian bone grafting. Implant geometry (shape and size) affects such osteogenic potentials. |
| first_indexed | 2025-11-15T10:06:32Z |
| format | Article |
| id | upm-44693 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T10:06:32Z |
| publishDate | 2015 |
| publisher | Wiley |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-446932021-04-20T04:21:01Z http://psasir.upm.edu.my/id/eprint/44693/ Evaluation of osteogenic potentials of avian demineralized bone matrix in the healing of osseous defects in pigeons Sanaei, Reza Abu, Jalila Nazari, Mojgan Abu Bakar @ Zakaria, Md Zuki Allaudin, Zeenathul Nazariah Objectives: To evaluate avian allogeneic demineralized bone matrix (DBM) in the healing of long bone defects as a function of geometry and time in a pigeon model. Study design: Experimental. Animals: Adult rock pigeons (n = 60). Methods: Midshaft ulnar osseous defects were grafted with 2 geometric forms of DBM (tubular vs. chipped) and stabilized with a hybrid fixator. Autologous chips of sternal keel were used in a third group as control. Outcomes were evaluated by radiography and histology/histomorphometry at 4, 8, 12, and 24 weeks postoperatively. Results: Despite an early rapid healing response, autografts plateaued (histologic score and new bone area) by 8 weeks with no significant improvement afterwards. Conversely, allogeneic DBM implants demonstrated continuous temporal improvement in bone healing, and tubular DBM finally outpaced autograft implants after week 12 with values for metrics achieving statistical significance by week 24. Chip DBM was inferior to tubular DBM and autograft. Conclusions: Avian DBM is osteogenic, biocompatible, and safe in orthotopic sites with potential usefulness in avian bone grafting. Implant geometry (shape and size) affects such osteogenic potentials. Wiley 2015-07 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/44693/1/Evaluation%20of%20osteogenic%20potentials%20of%20avian%20demineralized%20bone%20matrix%20in%20the%20healing%20of%20osseous%20defects%20in%20pigeons.pdf Sanaei, Reza and Abu, Jalila and Nazari, Mojgan and Abu Bakar @ Zakaria, Md Zuki and Allaudin, Zeenathul Nazariah (2015) Evaluation of osteogenic potentials of avian demineralized bone matrix in the healing of osseous defects in pigeons. Veterinary Surgery, 44 (5). pp. 603-612. ISSN 0161-3499; ESSN: 1532-950X https://onlinelibrary.wiley.com/doi/full/10.1111/vsu.12292 10.1111/VSU.12292 |
| spellingShingle | Sanaei, Reza Abu, Jalila Nazari, Mojgan Abu Bakar @ Zakaria, Md Zuki Allaudin, Zeenathul Nazariah Evaluation of osteogenic potentials of avian demineralized bone matrix in the healing of osseous defects in pigeons |
| title | Evaluation of osteogenic potentials of avian demineralized bone matrix in the healing of osseous defects in pigeons |
| title_full | Evaluation of osteogenic potentials of avian demineralized bone matrix in the healing of osseous defects in pigeons |
| title_fullStr | Evaluation of osteogenic potentials of avian demineralized bone matrix in the healing of osseous defects in pigeons |
| title_full_unstemmed | Evaluation of osteogenic potentials of avian demineralized bone matrix in the healing of osseous defects in pigeons |
| title_short | Evaluation of osteogenic potentials of avian demineralized bone matrix in the healing of osseous defects in pigeons |
| title_sort | evaluation of osteogenic potentials of avian demineralized bone matrix in the healing of osseous defects in pigeons |
| url | http://psasir.upm.edu.my/id/eprint/44693/ http://psasir.upm.edu.my/id/eprint/44693/ http://psasir.upm.edu.my/id/eprint/44693/ http://psasir.upm.edu.my/id/eprint/44693/1/Evaluation%20of%20osteogenic%20potentials%20of%20avian%20demineralized%20bone%20matrix%20in%20the%20healing%20of%20osseous%20defects%20in%20pigeons.pdf |