Cytotoxicity studies of tetraprelyltoluquinone, a prenilated hydroquinone from Garcina cowa Roxb on H-460, MCF-7 and DU-145
Objective: The aim of the present study was to examine the cytotoxicity of a new ring-reduced tetra prenyltoluquinone (TPTQ), [2E,6E,10E]-(+)-4b-hydroxy-3-methyl-5b-(3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenyl-2-cyclohexen-1-one against H-460, MCF-7 and DU-145 cell lines. Methods: Different co...
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| Format: | Article |
| Language: | English |
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Innovare Academic Sciences
2015
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| Online Access: | http://psasir.upm.edu.my/id/eprint/44233/ http://psasir.upm.edu.my/id/eprint/44233/1/Cytotoxicity%20studies%20of%20tetraprelyltoluquinone.pdf |
| _version_ | 1848850422351003648 |
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| author | Wahyuni, Fatma Sri Stanslas, Johnson Lajis, Nordin Hamidi, Dachriyanus |
| author_facet | Wahyuni, Fatma Sri Stanslas, Johnson Lajis, Nordin Hamidi, Dachriyanus |
| author_sort | Wahyuni, Fatma Sri |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Objective: The aim of the present study was to examine the cytotoxicity of a new ring-reduced tetra prenyltoluquinone (TPTQ), [2E,6E,10E]-(+)-4b-hydroxy-3-methyl-5b-(3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenyl-2-cyclohexen-1-one against H-460, MCF-7 and DU-145 cell lines. Methods: Different concentrations of TPTQ were subjected to cytotoxicity study by using MTT method and calculate the percentage of cell viability. Results: The results of this study showed that this compound has IC50 value 16.3 ± 3.0 µM in H-460 cancer cell lines without any activities towards another two type of cell lines. Conclusion: TPTQ had selective activity against H-460 cancer cell lines. |
| first_indexed | 2025-11-15T10:06:02Z |
| format | Article |
| id | upm-44233 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T10:06:02Z |
| publishDate | 2015 |
| publisher | Innovare Academic Sciences |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-442332018-01-17T03:34:02Z http://psasir.upm.edu.my/id/eprint/44233/ Cytotoxicity studies of tetraprelyltoluquinone, a prenilated hydroquinone from Garcina cowa Roxb on H-460, MCF-7 and DU-145 Wahyuni, Fatma Sri Stanslas, Johnson Lajis, Nordin Hamidi, Dachriyanus Objective: The aim of the present study was to examine the cytotoxicity of a new ring-reduced tetra prenyltoluquinone (TPTQ), [2E,6E,10E]-(+)-4b-hydroxy-3-methyl-5b-(3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenyl-2-cyclohexen-1-one against H-460, MCF-7 and DU-145 cell lines. Methods: Different concentrations of TPTQ were subjected to cytotoxicity study by using MTT method and calculate the percentage of cell viability. Results: The results of this study showed that this compound has IC50 value 16.3 ± 3.0 µM in H-460 cancer cell lines without any activities towards another two type of cell lines. Conclusion: TPTQ had selective activity against H-460 cancer cell lines. Innovare Academic Sciences 2015 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/44233/1/Cytotoxicity%20studies%20of%20tetraprelyltoluquinone.pdf Wahyuni, Fatma Sri and Stanslas, Johnson and Lajis, Nordin and Hamidi, Dachriyanus (2015) Cytotoxicity studies of tetraprelyltoluquinone, a prenilated hydroquinone from Garcina cowa Roxb on H-460, MCF-7 and DU-145. International Journal of Pharmacy and Pharmaceutical Sciences, 7 (3). pp. 60-63. ISSN 0975-1491 https://innovareacademics.in/journals/index.php/ijpps/article/view/3637 |
| spellingShingle | Wahyuni, Fatma Sri Stanslas, Johnson Lajis, Nordin Hamidi, Dachriyanus Cytotoxicity studies of tetraprelyltoluquinone, a prenilated hydroquinone from Garcina cowa Roxb on H-460, MCF-7 and DU-145 |
| title | Cytotoxicity studies of tetraprelyltoluquinone, a prenilated hydroquinone from Garcina cowa Roxb on H-460, MCF-7 and DU-145 |
| title_full | Cytotoxicity studies of tetraprelyltoluquinone, a prenilated hydroquinone from Garcina cowa Roxb on H-460, MCF-7 and DU-145 |
| title_fullStr | Cytotoxicity studies of tetraprelyltoluquinone, a prenilated hydroquinone from Garcina cowa Roxb on H-460, MCF-7 and DU-145 |
| title_full_unstemmed | Cytotoxicity studies of tetraprelyltoluquinone, a prenilated hydroquinone from Garcina cowa Roxb on H-460, MCF-7 and DU-145 |
| title_short | Cytotoxicity studies of tetraprelyltoluquinone, a prenilated hydroquinone from Garcina cowa Roxb on H-460, MCF-7 and DU-145 |
| title_sort | cytotoxicity studies of tetraprelyltoluquinone, a prenilated hydroquinone from garcina cowa roxb on h-460, mcf-7 and du-145 |
| url | http://psasir.upm.edu.my/id/eprint/44233/ http://psasir.upm.edu.my/id/eprint/44233/ http://psasir.upm.edu.my/id/eprint/44233/1/Cytotoxicity%20studies%20of%20tetraprelyltoluquinone.pdf |