Association of brain-derived neurotrophic factor valine to methionine polymorphism with sexual dysfunction following selective serotonin reuptake inhibitor treatment in female patients with major depressive disorder
Introduction: The occurrence of female sexual dysfunction (FSD) in patients with major depressive disorder (MDD) receiving selective serotonin reuptake inhibitors (SSRIs) treatment gives negative impacts on patients' quality of life and causes treatment discontinuation. We aimed to investigate...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015
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| Online Access: | http://psasir.upm.edu.my/id/eprint/43881/ http://psasir.upm.edu.my/id/eprint/43881/1/Association%20of%20brain-derived%20neurotrophic%20factor%20valine%20to%20methionine%20polymorphism%20.pdf |
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| author | Nazree, Nur Elia Mohamed, Zahurin Reynolds, Gavin P. Mohd Zain, Shamsul Masiran, Ruziana Sidi, Hatta Lu, Ann Chong Anne, Yee Hway Adlan, Aida Syarinaz Zainal, Nor Zuraida |
| author_facet | Nazree, Nur Elia Mohamed, Zahurin Reynolds, Gavin P. Mohd Zain, Shamsul Masiran, Ruziana Sidi, Hatta Lu, Ann Chong Anne, Yee Hway Adlan, Aida Syarinaz Zainal, Nor Zuraida |
| author_sort | Nazree, Nur Elia |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Introduction: The occurrence of female sexual dysfunction (FSD) in patients with major depressive disorder (MDD) receiving selective serotonin reuptake inhibitors (SSRIs) treatment gives negative impacts on patients' quality of life and causes treatment discontinuation. We aimed to investigate whether genetic polymorphism of identified candidate gene is associated with FSD in our study population.
Methods: This is a cross-sectional study. A total of 95 female patients with MDD who met the criteria of the study were recruited and were specifically assessed on the sexual function by trained psychiatrists. Patients' DNA was genotyped for BDNF Val66Met polymorphism using real-time polymerase chain reaction.
Results: The prevalence of FSD in this study is 31.6%. In the FSD group, patients with problematic marriage were significantly more frequent compared with patients who did not have problematic marriage (P=0.009). Significant association was detected in the lubrication domain with BDNF Val66Met polymorphism (P=0.030) using additive genetic model, with even stronger association when using the recessive model (P=0.013).
Discussion: This study suggested that there was no significant association between BDNF Val66Met with FSD. However, this polymorphism is significantly associated with lubrication disorder in patients treated with SSRIs. |
| first_indexed | 2025-11-15T10:04:52Z |
| format | Article |
| id | upm-43881 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T10:04:52Z |
| publishDate | 2015 |
| publisher | Wiley |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-438812016-10-27T01:37:41Z http://psasir.upm.edu.my/id/eprint/43881/ Association of brain-derived neurotrophic factor valine to methionine polymorphism with sexual dysfunction following selective serotonin reuptake inhibitor treatment in female patients with major depressive disorder Nazree, Nur Elia Mohamed, Zahurin Reynolds, Gavin P. Mohd Zain, Shamsul Masiran, Ruziana Sidi, Hatta Lu, Ann Chong Anne, Yee Hway Adlan, Aida Syarinaz Zainal, Nor Zuraida Introduction: The occurrence of female sexual dysfunction (FSD) in patients with major depressive disorder (MDD) receiving selective serotonin reuptake inhibitors (SSRIs) treatment gives negative impacts on patients' quality of life and causes treatment discontinuation. We aimed to investigate whether genetic polymorphism of identified candidate gene is associated with FSD in our study population. Methods: This is a cross-sectional study. A total of 95 female patients with MDD who met the criteria of the study were recruited and were specifically assessed on the sexual function by trained psychiatrists. Patients' DNA was genotyped for BDNF Val66Met polymorphism using real-time polymerase chain reaction. Results: The prevalence of FSD in this study is 31.6%. In the FSD group, patients with problematic marriage were significantly more frequent compared with patients who did not have problematic marriage (P=0.009). Significant association was detected in the lubrication domain with BDNF Val66Met polymorphism (P=0.030) using additive genetic model, with even stronger association when using the recessive model (P=0.013). Discussion: This study suggested that there was no significant association between BDNF Val66Met with FSD. However, this polymorphism is significantly associated with lubrication disorder in patients treated with SSRIs. Wiley 2015 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/43881/1/Association%20of%20brain-derived%20neurotrophic%20factor%20valine%20to%20methionine%20polymorphism%20.pdf Nazree, Nur Elia and Mohamed, Zahurin and Reynolds, Gavin P. and Mohd Zain, Shamsul and Masiran, Ruziana and Sidi, Hatta and Lu, Ann Chong and Anne, Yee Hway and Adlan, Aida Syarinaz and Zainal, Nor Zuraida (2015) Association of brain-derived neurotrophic factor valine to methionine polymorphism with sexual dysfunction following selective serotonin reuptake inhibitor treatment in female patients with major depressive disorder. Asia Pacific Psychiatry. ISSN 1758-5864; ESSN: 1758-5872 10.1111/appy.12210 |
| spellingShingle | Nazree, Nur Elia Mohamed, Zahurin Reynolds, Gavin P. Mohd Zain, Shamsul Masiran, Ruziana Sidi, Hatta Lu, Ann Chong Anne, Yee Hway Adlan, Aida Syarinaz Zainal, Nor Zuraida Association of brain-derived neurotrophic factor valine to methionine polymorphism with sexual dysfunction following selective serotonin reuptake inhibitor treatment in female patients with major depressive disorder |
| title | Association of brain-derived neurotrophic factor valine to methionine polymorphism with sexual dysfunction following selective serotonin reuptake inhibitor treatment in female patients with major depressive disorder |
| title_full | Association of brain-derived neurotrophic factor valine to methionine polymorphism with sexual dysfunction following selective serotonin reuptake inhibitor treatment in female patients with major depressive disorder |
| title_fullStr | Association of brain-derived neurotrophic factor valine to methionine polymorphism with sexual dysfunction following selective serotonin reuptake inhibitor treatment in female patients with major depressive disorder |
| title_full_unstemmed | Association of brain-derived neurotrophic factor valine to methionine polymorphism with sexual dysfunction following selective serotonin reuptake inhibitor treatment in female patients with major depressive disorder |
| title_short | Association of brain-derived neurotrophic factor valine to methionine polymorphism with sexual dysfunction following selective serotonin reuptake inhibitor treatment in female patients with major depressive disorder |
| title_sort | association of brain-derived neurotrophic factor valine to methionine polymorphism with sexual dysfunction following selective serotonin reuptake inhibitor treatment in female patients with major depressive disorder |
| url | http://psasir.upm.edu.my/id/eprint/43881/ http://psasir.upm.edu.my/id/eprint/43881/ http://psasir.upm.edu.my/id/eprint/43881/1/Association%20of%20brain-derived%20neurotrophic%20factor%20valine%20to%20methionine%20polymorphism%20.pdf |