Antistress and antioxidant effects of virgin coconut oil in vivo
Virgin coconut oil (VCO) has been consumed worldwide for various health-related reasons and some of its benefits have been scientifically evaluated. Medium-chain fatty acids were found to be a potential antidepressant functional food; however, this effect had not been evaluated in VCO, which is rich...
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| Format: | Article |
| Language: | English |
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Spandidos Publications
2015
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| Online Access: | http://psasir.upm.edu.my/id/eprint/43807/ http://psasir.upm.edu.my/id/eprint/43807/1/Antistress%20and%20antioxidant%20effects%20of%20virgin%20coconut%20oil%20in%20vivo.pdf |
| _version_ | 1848850328206704640 |
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| author | Swee, Keong Yeap Boon, Kee Beh Mohd Ali, Norlaily Mohd Yusof, Hamidah Wan, Yong Ho Soo, Peng Koh Alitheen, Noorjahan Banu Long, Kamariah |
| author_facet | Swee, Keong Yeap Boon, Kee Beh Mohd Ali, Norlaily Mohd Yusof, Hamidah Wan, Yong Ho Soo, Peng Koh Alitheen, Noorjahan Banu Long, Kamariah |
| author_sort | Swee, Keong Yeap |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Virgin coconut oil (VCO) has been consumed worldwide for various health-related reasons and some of its benefits have been scientifically evaluated. Medium-chain fatty acids were found to be a potential antidepressant functional food; however, this effect had not been evaluated in VCO, which is rich in polyphenols and medium-chain fatty acids. The aim of this study was to evaluate the antistress and antioxidant effects of VCO in vivo, using mice with stress-induced injury. The antistress effect of VCO (administered per os, at a dose of 10 ml/kg body weight) was evaluated using the forced swim test and chronic cold restraint stress models. VCO was able to reduce immobility time and restore oxidative stress in mice post-swim test. Furthermore, mice treated with VCO were found to exhibit higher levels of brain antioxidants, lower levels of brain 5-hydroxytryptamine and reduced weight of the adrenal glands. Consequently, the serum cholesterol, triglyceride, glucose and corticosterone levels were also lower in VCO-treated mice. These results suggest the potential value of VCO as an antistress functional oil. |
| first_indexed | 2025-11-15T10:04:32Z |
| format | Article |
| id | upm-43807 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T10:04:32Z |
| publishDate | 2015 |
| publisher | Spandidos Publications |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-438072016-09-21T04:39:05Z http://psasir.upm.edu.my/id/eprint/43807/ Antistress and antioxidant effects of virgin coconut oil in vivo Swee, Keong Yeap Boon, Kee Beh Mohd Ali, Norlaily Mohd Yusof, Hamidah Wan, Yong Ho Soo, Peng Koh Alitheen, Noorjahan Banu Long, Kamariah Virgin coconut oil (VCO) has been consumed worldwide for various health-related reasons and some of its benefits have been scientifically evaluated. Medium-chain fatty acids were found to be a potential antidepressant functional food; however, this effect had not been evaluated in VCO, which is rich in polyphenols and medium-chain fatty acids. The aim of this study was to evaluate the antistress and antioxidant effects of VCO in vivo, using mice with stress-induced injury. The antistress effect of VCO (administered per os, at a dose of 10 ml/kg body weight) was evaluated using the forced swim test and chronic cold restraint stress models. VCO was able to reduce immobility time and restore oxidative stress in mice post-swim test. Furthermore, mice treated with VCO were found to exhibit higher levels of brain antioxidants, lower levels of brain 5-hydroxytryptamine and reduced weight of the adrenal glands. Consequently, the serum cholesterol, triglyceride, glucose and corticosterone levels were also lower in VCO-treated mice. These results suggest the potential value of VCO as an antistress functional oil. Spandidos Publications 2015 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/43807/1/Antistress%20and%20antioxidant%20effects%20of%20virgin%20coconut%20oil%20in%20vivo.pdf Swee, Keong Yeap and Boon, Kee Beh and Mohd Ali, Norlaily and Mohd Yusof, Hamidah and Wan, Yong Ho and Soo, Peng Koh and Alitheen, Noorjahan Banu and Long, Kamariah (2015) Antistress and antioxidant effects of virgin coconut oil in vivo. Experimental and Therapeutic Medicine, 9 (1). pp. 39-42. ISSN 1792-0981; ESSN: 1792-1015 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247320/ 10.3892/etm.2014.2045 |
| spellingShingle | Swee, Keong Yeap Boon, Kee Beh Mohd Ali, Norlaily Mohd Yusof, Hamidah Wan, Yong Ho Soo, Peng Koh Alitheen, Noorjahan Banu Long, Kamariah Antistress and antioxidant effects of virgin coconut oil in vivo |
| title | Antistress and antioxidant effects of virgin coconut oil in vivo |
| title_full | Antistress and antioxidant effects of virgin coconut oil in vivo |
| title_fullStr | Antistress and antioxidant effects of virgin coconut oil in vivo |
| title_full_unstemmed | Antistress and antioxidant effects of virgin coconut oil in vivo |
| title_short | Antistress and antioxidant effects of virgin coconut oil in vivo |
| title_sort | antistress and antioxidant effects of virgin coconut oil in vivo |
| url | http://psasir.upm.edu.my/id/eprint/43807/ http://psasir.upm.edu.my/id/eprint/43807/ http://psasir.upm.edu.my/id/eprint/43807/ http://psasir.upm.edu.my/id/eprint/43807/1/Antistress%20and%20antioxidant%20effects%20of%20virgin%20coconut%20oil%20in%20vivo.pdf |