Antihypercholesterolemic and antioxidant efficacies of zerumbone on the formation, development, and establishment of atherosclerosis in cholesterol-fed rabbits
Owing to the high incidence of cholesterol-induced cardiovascular disease, particularly atherosclerosis, the current study was designed to investigate the preventive and therapeutic efficacies of dietary zerumbone (ZER) supplementation on the formation and development of atherosclerosis in rabbits f...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2015
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| Online Access: | http://psasir.upm.edu.my/id/eprint/43791/ http://psasir.upm.edu.my/id/eprint/43791/1/Antihypercholesterolemic%20and%20antioxidant%20efficacies%20of%20zerumbone%20on%20the%20formation%2C%20.pdf |
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| author | Othman, Hemn Hassan Mohamed Mustapha, Noordin Rahman, Heshu Sulaiman Hamzah, Hazilawati Abu Bakar @ Zakaria, Md Zuki Chartrand, Max Stanley |
| author_facet | Othman, Hemn Hassan Mohamed Mustapha, Noordin Rahman, Heshu Sulaiman Hamzah, Hazilawati Abu Bakar @ Zakaria, Md Zuki Chartrand, Max Stanley |
| author_sort | Othman, Hemn Hassan |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Owing to the high incidence of cholesterol-induced cardiovascular disease, particularly atherosclerosis, the current study was designed to investigate the preventive and therapeutic efficacies of dietary zerumbone (ZER) supplementation on the formation and development of atherosclerosis in rabbits fed with a high cholesterol diet. A total of 72 New Zealand white rabbits were divided randomly on two experimental studies carried out 8 weeks apart. The first experiment was designed to investigate the prophylactic efficacy of ZER in preventing early developed atheromatous lesion. The second experimental trial was aimed at investigating the therapeutic effect of ZER in reducing the atherosclerotic lesion progression and establishment. Sudanophilia, histopathological, and ultrastructural changes showed pronounced reduction in the plaque size in ZER-medicated aortas. On the other hand, dietary supplementation of ZER for almost 10 weeks as a prophylactic measure indicated substantially decreasing lipid profile values, and similarly, plaque size in comparison with high-cholesterol non-supplemented rabbits. Furthermore, the results of oxidative stress and antioxidant biomarker evaluation indicated that ZER is a potent antioxidant in suppressing the generation of free radicals in terms of atherosclerosis prevention and treatment. ZER significantly reduced the value of malondialdehyde and augmented the value of superoxide dismutase. In conclusion, our data indicated that dietary supplementation of ZER at doses of 8, 16, and 20 mg/kg alone as a prophylactic measure, and as a supplementary treatment with simvastatin, significantly reduced early plague formation, development, and establishment via significant reduction in serum lipid profile, together with suppression of oxidative damage, and therefore alleviated atherosclerosis lesions. |
| first_indexed | 2025-11-15T10:04:28Z |
| format | Article |
| id | upm-43791 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T10:04:28Z |
| publishDate | 2015 |
| publisher | Dove Medical Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-437912016-11-21T02:53:52Z http://psasir.upm.edu.my/id/eprint/43791/ Antihypercholesterolemic and antioxidant efficacies of zerumbone on the formation, development, and establishment of atherosclerosis in cholesterol-fed rabbits Othman, Hemn Hassan Mohamed Mustapha, Noordin Rahman, Heshu Sulaiman Hamzah, Hazilawati Abu Bakar @ Zakaria, Md Zuki Chartrand, Max Stanley Owing to the high incidence of cholesterol-induced cardiovascular disease, particularly atherosclerosis, the current study was designed to investigate the preventive and therapeutic efficacies of dietary zerumbone (ZER) supplementation on the formation and development of atherosclerosis in rabbits fed with a high cholesterol diet. A total of 72 New Zealand white rabbits were divided randomly on two experimental studies carried out 8 weeks apart. The first experiment was designed to investigate the prophylactic efficacy of ZER in preventing early developed atheromatous lesion. The second experimental trial was aimed at investigating the therapeutic effect of ZER in reducing the atherosclerotic lesion progression and establishment. Sudanophilia, histopathological, and ultrastructural changes showed pronounced reduction in the plaque size in ZER-medicated aortas. On the other hand, dietary supplementation of ZER for almost 10 weeks as a prophylactic measure indicated substantially decreasing lipid profile values, and similarly, plaque size in comparison with high-cholesterol non-supplemented rabbits. Furthermore, the results of oxidative stress and antioxidant biomarker evaluation indicated that ZER is a potent antioxidant in suppressing the generation of free radicals in terms of atherosclerosis prevention and treatment. ZER significantly reduced the value of malondialdehyde and augmented the value of superoxide dismutase. In conclusion, our data indicated that dietary supplementation of ZER at doses of 8, 16, and 20 mg/kg alone as a prophylactic measure, and as a supplementary treatment with simvastatin, significantly reduced early plague formation, development, and establishment via significant reduction in serum lipid profile, together with suppression of oxidative damage, and therefore alleviated atherosclerosis lesions. Dove Medical Press 2015 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/43791/1/Antihypercholesterolemic%20and%20antioxidant%20efficacies%20of%20zerumbone%20on%20the%20formation%2C%20.pdf Othman, Hemn Hassan and Mohamed Mustapha, Noordin and Rahman, Heshu Sulaiman and Hamzah, Hazilawati and Abu Bakar @ Zakaria, Md Zuki and Chartrand, Max Stanley (2015) Antihypercholesterolemic and antioxidant efficacies of zerumbone on the formation, development, and establishment of atherosclerosis in cholesterol-fed rabbits. Drug Design, Development and Therapy, 9. pp. 4173-4208. ISSN 1177-8881 https://www.dovepress.com/antihypercholesterolemic-and-antioxidant-efficacies-of-zerumbone-on-th-peer-reviewed-article-DDDT 10.2147/DDDT.S76225 |
| spellingShingle | Othman, Hemn Hassan Mohamed Mustapha, Noordin Rahman, Heshu Sulaiman Hamzah, Hazilawati Abu Bakar @ Zakaria, Md Zuki Chartrand, Max Stanley Antihypercholesterolemic and antioxidant efficacies of zerumbone on the formation, development, and establishment of atherosclerosis in cholesterol-fed rabbits |
| title | Antihypercholesterolemic and antioxidant efficacies of zerumbone on the formation, development, and establishment of atherosclerosis in cholesterol-fed rabbits |
| title_full | Antihypercholesterolemic and antioxidant efficacies of zerumbone on the formation, development, and establishment of atherosclerosis in cholesterol-fed rabbits |
| title_fullStr | Antihypercholesterolemic and antioxidant efficacies of zerumbone on the formation, development, and establishment of atherosclerosis in cholesterol-fed rabbits |
| title_full_unstemmed | Antihypercholesterolemic and antioxidant efficacies of zerumbone on the formation, development, and establishment of atherosclerosis in cholesterol-fed rabbits |
| title_short | Antihypercholesterolemic and antioxidant efficacies of zerumbone on the formation, development, and establishment of atherosclerosis in cholesterol-fed rabbits |
| title_sort | antihypercholesterolemic and antioxidant efficacies of zerumbone on the formation, development, and establishment of atherosclerosis in cholesterol-fed rabbits |
| url | http://psasir.upm.edu.my/id/eprint/43791/ http://psasir.upm.edu.my/id/eprint/43791/ http://psasir.upm.edu.my/id/eprint/43791/ http://psasir.upm.edu.my/id/eprint/43791/1/Antihypercholesterolemic%20and%20antioxidant%20efficacies%20of%20zerumbone%20on%20the%20formation%2C%20.pdf |