Antiallodynic and antihyperalgesic effects of zerumbone on a mouse model of chronic constriction injury-induced neuropathic pain
Neuropathic pain is a chronic condition that is difficult to be treated. Current therapies available are either ineffective or non-specific thus requiring newer treatment approaches. In this study, we investigated the antiallodynic and antihyperalgesic effects of zerumbone, a bioactive sesquiterpene...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2015
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/43782/ http://psasir.upm.edu.my/id/eprint/43782/2/1-s2.0-S0367326X15300484-main.pdf |
| _version_ | 1848850321346920448 |
|---|---|
| author | Zulazmi, Nurul Atiqah Gopalsamy, Banulata Omar Farouk, Ahmad Akira Sulaiman, Mohd Roslan Bharatham, Hemabarathy Perimal, Enoch Kumar |
| author_facet | Zulazmi, Nurul Atiqah Gopalsamy, Banulata Omar Farouk, Ahmad Akira Sulaiman, Mohd Roslan Bharatham, Hemabarathy Perimal, Enoch Kumar |
| author_sort | Zulazmi, Nurul Atiqah |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Neuropathic pain is a chronic condition that is difficult to be treated. Current therapies available are either ineffective or non-specific thus requiring newer treatment approaches. In this study, we investigated the antiallodynic and antihyperalgesic effects of zerumbone, a bioactive sesquiterpene from Zingiber zerumbet in chronic constriction injury (CCI)-induced neuropathic pain animal model. Our findings showed that single and repeated dose of intra-peritoneal administration of zerumbone (5, 10, 50, 100 mg/kg) significantly attenuated the CCI-induced neuropathic pain when evaluated using the electronic von Frey anesthesiometer, cold plate, Randall-Selitto analgesiometer and the Hargreaves plantar test. Zerumbone significantly alleviated tactile and cold allodynia as well as mechanical and thermal hyperalgesia. Our findings are in comparison to the positive control drugs thatused gabapentin (20 mg/kgi.p.) and morphine (1 mg/kgi.p.). Together, these results showed that the systemic administration of zerumbone produced marked antiallodynic and antihyperalgesic effects in the CCI-induced neuropathic pain in mice and may serve as a potential lead compound for further analysis. |
| first_indexed | 2025-11-15T10:04:26Z |
| format | Article |
| id | upm-43782 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T10:04:26Z |
| publishDate | 2015 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-437822016-09-21T02:43:43Z http://psasir.upm.edu.my/id/eprint/43782/ Antiallodynic and antihyperalgesic effects of zerumbone on a mouse model of chronic constriction injury-induced neuropathic pain Zulazmi, Nurul Atiqah Gopalsamy, Banulata Omar Farouk, Ahmad Akira Sulaiman, Mohd Roslan Bharatham, Hemabarathy Perimal, Enoch Kumar Neuropathic pain is a chronic condition that is difficult to be treated. Current therapies available are either ineffective or non-specific thus requiring newer treatment approaches. In this study, we investigated the antiallodynic and antihyperalgesic effects of zerumbone, a bioactive sesquiterpene from Zingiber zerumbet in chronic constriction injury (CCI)-induced neuropathic pain animal model. Our findings showed that single and repeated dose of intra-peritoneal administration of zerumbone (5, 10, 50, 100 mg/kg) significantly attenuated the CCI-induced neuropathic pain when evaluated using the electronic von Frey anesthesiometer, cold plate, Randall-Selitto analgesiometer and the Hargreaves plantar test. Zerumbone significantly alleviated tactile and cold allodynia as well as mechanical and thermal hyperalgesia. Our findings are in comparison to the positive control drugs thatused gabapentin (20 mg/kgi.p.) and morphine (1 mg/kgi.p.). Together, these results showed that the systemic administration of zerumbone produced marked antiallodynic and antihyperalgesic effects in the CCI-induced neuropathic pain in mice and may serve as a potential lead compound for further analysis. Elsevier 2015 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/43782/2/1-s2.0-S0367326X15300484-main.pdf Zulazmi, Nurul Atiqah and Gopalsamy, Banulata and Omar Farouk, Ahmad Akira and Sulaiman, Mohd Roslan and Bharatham, Hemabarathy and Perimal, Enoch Kumar (2015) Antiallodynic and antihyperalgesic effects of zerumbone on a mouse model of chronic constriction injury-induced neuropathic pain. Fitoterapia, 105. pp. 215-221. ISSN 0367-326X; ESSN: 1873-6971 http://www.elsevier.com/locate/fitote 10.1016/j.fitote.2015.07.011 |
| spellingShingle | Zulazmi, Nurul Atiqah Gopalsamy, Banulata Omar Farouk, Ahmad Akira Sulaiman, Mohd Roslan Bharatham, Hemabarathy Perimal, Enoch Kumar Antiallodynic and antihyperalgesic effects of zerumbone on a mouse model of chronic constriction injury-induced neuropathic pain |
| title | Antiallodynic and antihyperalgesic effects of zerumbone on a mouse model of chronic constriction injury-induced neuropathic pain |
| title_full | Antiallodynic and antihyperalgesic effects of zerumbone on a mouse model of chronic constriction injury-induced neuropathic pain |
| title_fullStr | Antiallodynic and antihyperalgesic effects of zerumbone on a mouse model of chronic constriction injury-induced neuropathic pain |
| title_full_unstemmed | Antiallodynic and antihyperalgesic effects of zerumbone on a mouse model of chronic constriction injury-induced neuropathic pain |
| title_short | Antiallodynic and antihyperalgesic effects of zerumbone on a mouse model of chronic constriction injury-induced neuropathic pain |
| title_sort | antiallodynic and antihyperalgesic effects of zerumbone on a mouse model of chronic constriction injury-induced neuropathic pain |
| url | http://psasir.upm.edu.my/id/eprint/43782/ http://psasir.upm.edu.my/id/eprint/43782/ http://psasir.upm.edu.my/id/eprint/43782/ http://psasir.upm.edu.my/id/eprint/43782/2/1-s2.0-S0367326X15300484-main.pdf |