Angiotensin-I converting enzyme (ACE) inhibitory and anti-oxidant activities of sea cucumber (Actinopyga lecanora) hydrolysates
In recent years, food protein-derived hydrolysates have received considerable attention because of their numerous health benefits. Amongst the hydrolysates, those with anti-hypertensive and anti-oxidative activities are receiving special attention as both activities can play significant roles in pre...
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| Format: | Article |
| Language: | English |
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MDPI
2015
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| Online Access: | http://psasir.upm.edu.my/id/eprint/43775/ http://psasir.upm.edu.my/id/eprint/43775/1/Angiotensin-I%20Converting%20Enzyme%20%28ACE%29%20Inhibitory.pdf |
| _version_ | 1848850319431172096 |
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| author | Ghanbari, Raheleh Zarei, Mohammad Ebrahimpour, Afshin Abdul Hamid, Azizah Ismail, Amin Saari, Nazamid |
| author_facet | Ghanbari, Raheleh Zarei, Mohammad Ebrahimpour, Afshin Abdul Hamid, Azizah Ismail, Amin Saari, Nazamid |
| author_sort | Ghanbari, Raheleh |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | In recent years, food protein-derived hydrolysates have received considerable attention because of their numerous health benefits. Amongst the hydrolysates, those with anti-hypertensive and anti-oxidative activities are receiving special attention as both activities can play significant roles in preventing cardiovascular diseases. The present study investigated the angiotensin-I converting enzyme (ACE) inhibitory and anti-oxidative activities of Actinopyga lecanora (A. lecanora) hydrolysates, which had been prepared by alcalase, papain, bromelain, flavourzyme, pepsin, and trypsin under their optimum conditions. The alcalase hydrolysate showed the highest ACE inhibitory activity (69.8%) after 8 h of hydrolysis while the highest anti-oxidative activities measured by 2,2-diphenyl 1-1-picrylhydrazyl radical scavenging (DPPH) (56.00%) and ferrous ion-chelating (FIC) (59.00%) methods were exhibited after 24 h and 8 h of hydrolysis, respectively. The ACE-inhibitory and anti-oxidative activities displayed dose-dependent trends, and increased with increasing protein hydrolysate concentrations. Moreover, strong positive correlations between angiotensin-I converting enzyme (ACE) inhibitory and anti-oxidative activities were also observed. This study indicates that A. lecanora hydrolysate can be exploited as a source of functional food owing to its anti-oxidant as well as anti-hypertension functions. |
| first_indexed | 2025-11-15T10:04:24Z |
| format | Article |
| id | upm-43775 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T10:04:24Z |
| publishDate | 2015 |
| publisher | MDPI |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-437752016-09-20T09:22:30Z http://psasir.upm.edu.my/id/eprint/43775/ Angiotensin-I converting enzyme (ACE) inhibitory and anti-oxidant activities of sea cucumber (Actinopyga lecanora) hydrolysates Ghanbari, Raheleh Zarei, Mohammad Ebrahimpour, Afshin Abdul Hamid, Azizah Ismail, Amin Saari, Nazamid In recent years, food protein-derived hydrolysates have received considerable attention because of their numerous health benefits. Amongst the hydrolysates, those with anti-hypertensive and anti-oxidative activities are receiving special attention as both activities can play significant roles in preventing cardiovascular diseases. The present study investigated the angiotensin-I converting enzyme (ACE) inhibitory and anti-oxidative activities of Actinopyga lecanora (A. lecanora) hydrolysates, which had been prepared by alcalase, papain, bromelain, flavourzyme, pepsin, and trypsin under their optimum conditions. The alcalase hydrolysate showed the highest ACE inhibitory activity (69.8%) after 8 h of hydrolysis while the highest anti-oxidative activities measured by 2,2-diphenyl 1-1-picrylhydrazyl radical scavenging (DPPH) (56.00%) and ferrous ion-chelating (FIC) (59.00%) methods were exhibited after 24 h and 8 h of hydrolysis, respectively. The ACE-inhibitory and anti-oxidative activities displayed dose-dependent trends, and increased with increasing protein hydrolysate concentrations. Moreover, strong positive correlations between angiotensin-I converting enzyme (ACE) inhibitory and anti-oxidative activities were also observed. This study indicates that A. lecanora hydrolysate can be exploited as a source of functional food owing to its anti-oxidant as well as anti-hypertension functions. MDPI 2015 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/43775/1/Angiotensin-I%20Converting%20Enzyme%20%28ACE%29%20Inhibitory.pdf Ghanbari, Raheleh and Zarei, Mohammad and Ebrahimpour, Afshin and Abdul Hamid, Azizah and Ismail, Amin and Saari, Nazamid (2015) Angiotensin-I converting enzyme (ACE) inhibitory and anti-oxidant activities of sea cucumber (Actinopyga lecanora) hydrolysates. International Journal of Molecular Sciences, 16 (12). pp. 28870-28885. ISSN 1661-6596; ESSN: 1422-0067 http://www.mdpi.com/journal/ijms 10.3390/ijms161226140 |
| spellingShingle | Ghanbari, Raheleh Zarei, Mohammad Ebrahimpour, Afshin Abdul Hamid, Azizah Ismail, Amin Saari, Nazamid Angiotensin-I converting enzyme (ACE) inhibitory and anti-oxidant activities of sea cucumber (Actinopyga lecanora) hydrolysates |
| title | Angiotensin-I converting enzyme (ACE) inhibitory and anti-oxidant activities of sea cucumber (Actinopyga lecanora) hydrolysates |
| title_full | Angiotensin-I converting enzyme (ACE) inhibitory and anti-oxidant activities of sea cucumber (Actinopyga lecanora) hydrolysates |
| title_fullStr | Angiotensin-I converting enzyme (ACE) inhibitory and anti-oxidant activities of sea cucumber (Actinopyga lecanora) hydrolysates |
| title_full_unstemmed | Angiotensin-I converting enzyme (ACE) inhibitory and anti-oxidant activities of sea cucumber (Actinopyga lecanora) hydrolysates |
| title_short | Angiotensin-I converting enzyme (ACE) inhibitory and anti-oxidant activities of sea cucumber (Actinopyga lecanora) hydrolysates |
| title_sort | angiotensin-i converting enzyme (ace) inhibitory and anti-oxidant activities of sea cucumber (actinopyga lecanora) hydrolysates |
| url | http://psasir.upm.edu.my/id/eprint/43775/ http://psasir.upm.edu.my/id/eprint/43775/ http://psasir.upm.edu.my/id/eprint/43775/ http://psasir.upm.edu.my/id/eprint/43775/1/Angiotensin-I%20Converting%20Enzyme%20%28ACE%29%20Inhibitory.pdf |