Acetyl-cholinesterase enzyme inhibitory effect of calophyllum species
Purpose: To search for new acetylcholinesterase enzyme inhibitors from Calopyllum species. Methods: Six stem bark extracts of Calophyllum inophyllum, C. soulattri, C. teysmannii, C. lowii, C. benjaminum and C. javanicum were subjected to anti-cholinesterase analysis against acetylcholinesterase (...
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| Format: | Article |
| Language: | English |
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Pharmacotherapy Group, Faculty of Pharmacy, University of Benin
2015
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| Online Access: | http://psasir.upm.edu.my/id/eprint/43642/ http://psasir.upm.edu.my/id/eprint/43642/1/Acetyl-cholinesterase%20enzyme%20inhibitory%20effect%20of%20calophyllum%20species.pdf |
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| author | Cheng, Gwendoline Lian Ee Soek, Sin Teh Siau, Hui Mah Jamaluddin, Nur Ain Muhamad Sahimi, Muhamad Syarik Ahmad, Zuraini |
| author_facet | Cheng, Gwendoline Lian Ee Soek, Sin Teh Siau, Hui Mah Jamaluddin, Nur Ain Muhamad Sahimi, Muhamad Syarik Ahmad, Zuraini |
| author_sort | Cheng, Gwendoline Lian Ee |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Purpose: To search for new acetylcholinesterase enzyme inhibitors from Calopyllum species.
Methods: Six stem bark extracts of Calophyllum inophyllum, C. soulattri, C. teysmannii, C. lowii, C. benjaminum and C. javanicum were subjected to anti-cholinesterase analysis against acetylcholinesterase (AChE) enzyme using Ellman’s method.
Results: Most of the extracts showed promising inhibitory activity against AChE at concentrations of 100 μg/mL, with the methanol extract of C. inophyllum demonstrating the strongest inhibitory effect of 81.28 % followed by the methanol extract of C. benjaminum with 74.32 % inhibition. The methanol extracts of Calophyllum inophyllum and Calophyllum bejaminum also showed significant inhibitory activity towards the acetylcholinesterase (AChE) enzyme.
Conclusion: Calophyllum species is capable of yielding potential lead compounds for the development for acetyl-cholinesterase enzyme inhibition drugs.
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| first_indexed | 2025-11-15T10:03:49Z |
| format | Article |
| id | upm-43642 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T10:03:49Z |
| publishDate | 2015 |
| publisher | Pharmacotherapy Group, Faculty of Pharmacy, University of Benin |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-436422016-07-22T02:47:23Z http://psasir.upm.edu.my/id/eprint/43642/ Acetyl-cholinesterase enzyme inhibitory effect of calophyllum species Cheng, Gwendoline Lian Ee Soek, Sin Teh Siau, Hui Mah Jamaluddin, Nur Ain Muhamad Sahimi, Muhamad Syarik Ahmad, Zuraini Purpose: To search for new acetylcholinesterase enzyme inhibitors from Calopyllum species. Methods: Six stem bark extracts of Calophyllum inophyllum, C. soulattri, C. teysmannii, C. lowii, C. benjaminum and C. javanicum were subjected to anti-cholinesterase analysis against acetylcholinesterase (AChE) enzyme using Ellman’s method. Results: Most of the extracts showed promising inhibitory activity against AChE at concentrations of 100 μg/mL, with the methanol extract of C. inophyllum demonstrating the strongest inhibitory effect of 81.28 % followed by the methanol extract of C. benjaminum with 74.32 % inhibition. The methanol extracts of Calophyllum inophyllum and Calophyllum bejaminum also showed significant inhibitory activity towards the acetylcholinesterase (AChE) enzyme. Conclusion: Calophyllum species is capable of yielding potential lead compounds for the development for acetyl-cholinesterase enzyme inhibition drugs. Pharmacotherapy Group, Faculty of Pharmacy, University of Benin 2015 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/43642/1/Acetyl-cholinesterase%20enzyme%20inhibitory%20effect%20of%20calophyllum%20species.pdf Cheng, Gwendoline Lian Ee and Soek, Sin Teh and Siau, Hui Mah and Jamaluddin, Nur Ain and Muhamad Sahimi, Muhamad Syarik and Ahmad, Zuraini (2015) Acetyl-cholinesterase enzyme inhibitory effect of calophyllum species. Tropical Journal of Pharmaceutical Research, 14 (11). pp. 1319-1326. ISSN 1596-5996; ESSN: 1596-9827 http://www.bioline.org.br/pdf?pr15262 10.4314/tjpr.v14i11.8 |
| spellingShingle | Cheng, Gwendoline Lian Ee Soek, Sin Teh Siau, Hui Mah Jamaluddin, Nur Ain Muhamad Sahimi, Muhamad Syarik Ahmad, Zuraini Acetyl-cholinesterase enzyme inhibitory effect of calophyllum species |
| title | Acetyl-cholinesterase enzyme inhibitory effect of calophyllum species |
| title_full | Acetyl-cholinesterase enzyme inhibitory effect of calophyllum species |
| title_fullStr | Acetyl-cholinesterase enzyme inhibitory effect of calophyllum species |
| title_full_unstemmed | Acetyl-cholinesterase enzyme inhibitory effect of calophyllum species |
| title_short | Acetyl-cholinesterase enzyme inhibitory effect of calophyllum species |
| title_sort | acetyl-cholinesterase enzyme inhibitory effect of calophyllum species |
| url | http://psasir.upm.edu.my/id/eprint/43642/ http://psasir.upm.edu.my/id/eprint/43642/ http://psasir.upm.edu.my/id/eprint/43642/ http://psasir.upm.edu.my/id/eprint/43642/1/Acetyl-cholinesterase%20enzyme%20inhibitory%20effect%20of%20calophyllum%20species.pdf |