Acetyl-cholinesterase enzyme inhibitory effect of calophyllum species
Purpose: To search for new acetylcholinesterase enzyme inhibitors from Calopyllum species. Methods: Six stem bark extracts of Calophyllum inophyllum, C. soulattri, C. teysmannii, C. lowii, C. benjaminum and C. javanicum were subjected to anti-cholinesterase analysis against acetylcholinesterase (...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin
2015
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| Online Access: | http://psasir.upm.edu.my/id/eprint/43642/ http://psasir.upm.edu.my/id/eprint/43642/1/Acetyl-cholinesterase%20enzyme%20inhibitory%20effect%20of%20calophyllum%20species.pdf |
| Summary: | Purpose: To search for new acetylcholinesterase enzyme inhibitors from Calopyllum species.
Methods: Six stem bark extracts of Calophyllum inophyllum, C. soulattri, C. teysmannii, C. lowii, C. benjaminum and C. javanicum were subjected to anti-cholinesterase analysis against acetylcholinesterase (AChE) enzyme using Ellman’s method.
Results: Most of the extracts showed promising inhibitory activity against AChE at concentrations of 100 μg/mL, with the methanol extract of C. inophyllum demonstrating the strongest inhibitory effect of 81.28 % followed by the methanol extract of C. benjaminum with 74.32 % inhibition. The methanol extracts of Calophyllum inophyllum and Calophyllum bejaminum also showed significant inhibitory activity towards the acetylcholinesterase (AChE) enzyme.
Conclusion: Calophyllum species is capable of yielding potential lead compounds for the development for acetyl-cholinesterase enzyme inhibition drugs.
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