A case series of acquired haemophilia in a Malaysian hospital: unpredictabty rare medical emergency
Acquired haemophilia (AH) is a rare bleeding disorder characterized by the presence of acquired inhibitors against Factor VIII causing disruption of coagulation cascade. It has no known genetic inheritance, and diagnosis remains a challenge. The peculiar presentations are later age of onset as acute...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Oxford University Press
2015
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| Online Access: | http://psasir.upm.edu.my/id/eprint/43462/ http://psasir.upm.edu.my/id/eprint/43462/1/abstract123.pdf |
| _version_ | 1848850234966278144 |
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| author | Chiou, Perng Lee Khalid, Bahariah |
| author_facet | Chiou, Perng Lee Khalid, Bahariah |
| author_sort | Chiou, Perng Lee |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Acquired haemophilia (AH) is a rare bleeding disorder characterized by the presence of acquired inhibitors against Factor VIII causing disruption of coagulation cascade. It has no known genetic inheritance, and diagnosis remains a challenge. The peculiar presentations are later age of onset as acute pain in weight-bearing joints and spontaneous muscle haematoma with isolated prolonged activated partial thrombin time (APTT). Prevalence is 1 per million per year affecting both genders equally where blood product transfusion is seen in almost 87% of cases. The direct cause of AH is still unknown, and autoimmune dysregulation has been postulated, which predisposes to the development of the factor inhibitors. Being extremely rare, we are reporting two consecutive patients diagnosed by unusual bleeding episodes with isolated prolonged APTT due to Factor VIII inhibitors. AH deserves a special mention as high index of suspicion is required. More studies are required to provide better guidance in diagnosis and management of this condition. |
| first_indexed | 2025-11-15T10:03:03Z |
| format | Article |
| id | upm-43462 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T10:03:03Z |
| publishDate | 2015 |
| publisher | Oxford University Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-434622016-06-28T03:35:03Z http://psasir.upm.edu.my/id/eprint/43462/ A case series of acquired haemophilia in a Malaysian hospital: unpredictabty rare medical emergency Chiou, Perng Lee Khalid, Bahariah Acquired haemophilia (AH) is a rare bleeding disorder characterized by the presence of acquired inhibitors against Factor VIII causing disruption of coagulation cascade. It has no known genetic inheritance, and diagnosis remains a challenge. The peculiar presentations are later age of onset as acute pain in weight-bearing joints and spontaneous muscle haematoma with isolated prolonged activated partial thrombin time (APTT). Prevalence is 1 per million per year affecting both genders equally where blood product transfusion is seen in almost 87% of cases. The direct cause of AH is still unknown, and autoimmune dysregulation has been postulated, which predisposes to the development of the factor inhibitors. Being extremely rare, we are reporting two consecutive patients diagnosed by unusual bleeding episodes with isolated prolonged APTT due to Factor VIII inhibitors. AH deserves a special mention as high index of suspicion is required. More studies are required to provide better guidance in diagnosis and management of this condition. Oxford University Press 2015 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/43462/1/abstract123.pdf Chiou, Perng Lee and Khalid, Bahariah (2015) A case series of acquired haemophilia in a Malaysian hospital: unpredictabty rare medical emergency. Oxford Medical Case Reports, 2015 (10). pp. 330-332. ISSN 2053-8855 10.1093/omcr/omv055 |
| spellingShingle | Chiou, Perng Lee Khalid, Bahariah A case series of acquired haemophilia in a Malaysian hospital: unpredictabty rare medical emergency |
| title | A case series of acquired haemophilia in a Malaysian hospital: unpredictabty rare medical emergency |
| title_full | A case series of acquired haemophilia in a Malaysian hospital: unpredictabty rare medical emergency |
| title_fullStr | A case series of acquired haemophilia in a Malaysian hospital: unpredictabty rare medical emergency |
| title_full_unstemmed | A case series of acquired haemophilia in a Malaysian hospital: unpredictabty rare medical emergency |
| title_short | A case series of acquired haemophilia in a Malaysian hospital: unpredictabty rare medical emergency |
| title_sort | case series of acquired haemophilia in a malaysian hospital: unpredictabty rare medical emergency |
| url | http://psasir.upm.edu.my/id/eprint/43462/ http://psasir.upm.edu.my/id/eprint/43462/ http://psasir.upm.edu.my/id/eprint/43462/1/abstract123.pdf |