Influence of Corynebacterium pseudotuberculosis infection on level of acute phase proteins in goats
Background: Goat caseous lymphadenitis (CLA) is a chronic disease caused by Corynebacterium pseudotuberculosis. However, there is paucity of data about goat's acute phase response during the course of CLA. This study was conducted to investigate the response of acute phase proteins, mainly hapt...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BioMed Central
2016
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/43409/ http://psasir.upm.edu.my/id/eprint/43409/1/43409.pdf |
| _version_ | 1848850220936331264 |
|---|---|
| author | Jeber, Z. K. H. Md. Jinin @ Md. Janin, Zurin Azlin @ Zurinazlin Abdullah, Faez Firdaus Jesse Saharee, Abdul Aziz Sabri, Jasni Yusoff, Rosnina Haron, Abd Wahid |
| author_facet | Jeber, Z. K. H. Md. Jinin @ Md. Janin, Zurin Azlin @ Zurinazlin Abdullah, Faez Firdaus Jesse Saharee, Abdul Aziz Sabri, Jasni Yusoff, Rosnina Haron, Abd Wahid |
| author_sort | Jeber, Z. K. H. |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Background: Goat caseous lymphadenitis (CLA) is a chronic disease caused by Corynebacterium pseudotuberculosis. However, there is paucity of data about goat's acute phase response during the course of CLA. This study was conducted to investigate the response of acute phase proteins, mainly haptoglobin (Hp), serum amyloid A (SAA) and the negative acute phase response, especially albumin after an experimental challenge of C. pseudotuberculosis and phospholipase D (PLD) in Cross bred Boer goats. Results: Serum Hp concentration in goats challenged with C. pseudotuberculosis (inoculated with 1x109 cfu subcutaneously) showed a significant increase, 5 fold in males (0.98±0.12mg/ml) and 3 fold in females (0.66±0.12mg/ml) compared to the control (0.2±0.02mg/ml). Challenge with PLD (1ml/20kg body weight intravenously) also showed significant increase, 4 fold in males and females (0.89±0.11mg/ml; 0.82±0.12mg/ml) respectively compared to the control (0.2±0.02mg/ml). Albumin concentration showed a significant decrease in both treated groups compared to the control. There were no significant changes in SAA concentration between challenged and control goats. Conclusions: There was a significant response by Hp to C. pseudotuberculosis infection and PLD challenge. This was supported by the early acute response in which Hp was detected before CLA lesions were developed. Therefore, it concluded that C. pseudotuberculosis and PLD can influence the level of acute phase proteins in goats. |
| first_indexed | 2025-11-15T10:02:50Z |
| format | Article |
| id | upm-43409 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T10:02:50Z |
| publishDate | 2016 |
| publisher | BioMed Central |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-434092016-05-19T02:09:08Z http://psasir.upm.edu.my/id/eprint/43409/ Influence of Corynebacterium pseudotuberculosis infection on level of acute phase proteins in goats Jeber, Z. K. H. Md. Jinin @ Md. Janin, Zurin Azlin @ Zurinazlin Abdullah, Faez Firdaus Jesse Saharee, Abdul Aziz Sabri, Jasni Yusoff, Rosnina Haron, Abd Wahid Background: Goat caseous lymphadenitis (CLA) is a chronic disease caused by Corynebacterium pseudotuberculosis. However, there is paucity of data about goat's acute phase response during the course of CLA. This study was conducted to investigate the response of acute phase proteins, mainly haptoglobin (Hp), serum amyloid A (SAA) and the negative acute phase response, especially albumin after an experimental challenge of C. pseudotuberculosis and phospholipase D (PLD) in Cross bred Boer goats. Results: Serum Hp concentration in goats challenged with C. pseudotuberculosis (inoculated with 1x109 cfu subcutaneously) showed a significant increase, 5 fold in males (0.98±0.12mg/ml) and 3 fold in females (0.66±0.12mg/ml) compared to the control (0.2±0.02mg/ml). Challenge with PLD (1ml/20kg body weight intravenously) also showed significant increase, 4 fold in males and females (0.89±0.11mg/ml; 0.82±0.12mg/ml) respectively compared to the control (0.2±0.02mg/ml). Albumin concentration showed a significant decrease in both treated groups compared to the control. There were no significant changes in SAA concentration between challenged and control goats. Conclusions: There was a significant response by Hp to C. pseudotuberculosis infection and PLD challenge. This was supported by the early acute response in which Hp was detected before CLA lesions were developed. Therefore, it concluded that C. pseudotuberculosis and PLD can influence the level of acute phase proteins in goats. BioMed Central 2016 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/43409/1/43409.pdf Jeber, Z. K. H. and Md. Jinin @ Md. Janin, Zurin Azlin @ Zurinazlin and Abdullah, Faez Firdaus Jesse and Saharee, Abdul Aziz and Sabri, Jasni and Yusoff, Rosnina and Haron, Abd Wahid (2016) Influence of Corynebacterium pseudotuberculosis infection on level of acute phase proteins in goats. BMC Veterinary Research, 12 (1). art. no. 48. pp. 1-5. ISSN 1746-6148 http://link.springer.com/article/10.1186/s12917-016-0675-y?view=classic 10.1186/s12917-016-0675-y |
| spellingShingle | Jeber, Z. K. H. Md. Jinin @ Md. Janin, Zurin Azlin @ Zurinazlin Abdullah, Faez Firdaus Jesse Saharee, Abdul Aziz Sabri, Jasni Yusoff, Rosnina Haron, Abd Wahid Influence of Corynebacterium pseudotuberculosis infection on level of acute phase proteins in goats |
| title | Influence of Corynebacterium pseudotuberculosis infection on level of acute phase proteins in goats |
| title_full | Influence of Corynebacterium pseudotuberculosis infection on level of acute phase proteins in goats |
| title_fullStr | Influence of Corynebacterium pseudotuberculosis infection on level of acute phase proteins in goats |
| title_full_unstemmed | Influence of Corynebacterium pseudotuberculosis infection on level of acute phase proteins in goats |
| title_short | Influence of Corynebacterium pseudotuberculosis infection on level of acute phase proteins in goats |
| title_sort | influence of corynebacterium pseudotuberculosis infection on level of acute phase proteins in goats |
| url | http://psasir.upm.edu.my/id/eprint/43409/ http://psasir.upm.edu.my/id/eprint/43409/ http://psasir.upm.edu.my/id/eprint/43409/ http://psasir.upm.edu.my/id/eprint/43409/1/43409.pdf |