Sequence of the haemagglutinin-neuraminidase gene of the Newcastle disease virus oral vaccine strain V4(UPM)
The nucleotide sequence of the haemagglutinin‐neuraminidase (HN) glycoprotein gene of Newcastle disease virus (NDV) variant strain V4(UPM) was determined by direct genomic RNA sequencing and confirmed by cycle sequencing. The gene comprises 1996 nucleotides encoding a 615 amino acid protein of size...
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| Format: | Article |
| Language: | English English |
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Houghton Trust
1996
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| Online Access: | http://psasir.upm.edu.my/id/eprint/42345/ http://psasir.upm.edu.my/id/eprint/42345/1/Sequence%20of%20the%20haemagglutinin-neuraminidase%20gene%20of%20the%20Newcastle%20disease%20virus%20oral%20vaccine%20strain%20V4%28UPM%29.pdf http://psasir.upm.edu.my/id/eprint/42345/7/Sequence%20of%20the%20haemagglutinin%20neuraminidase%20gene%20of%20the%20Newcastle%20disease%20virus%20oral%20vaccine%20strain%20V4%20UPM%20.pdf |
| _version_ | 1848849937835491328 |
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| author | Yusoff, Khatijah Tan, Wen Siang Lau, Chin Hoon Ng, Ban Kim Ibrahim, Abdul Latif |
| author_facet | Yusoff, Khatijah Tan, Wen Siang Lau, Chin Hoon Ng, Ban Kim Ibrahim, Abdul Latif |
| author_sort | Yusoff, Khatijah |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | The nucleotide sequence of the haemagglutinin‐neuraminidase (HN) glycoprotein gene of Newcastle disease virus (NDV) variant strain V4(UPM) was determined by direct genomic RNA sequencing and confirmed by cycle sequencing. The gene comprises 1996 nucleotides encoding a 615 amino acid protein of size 67.4 kDa. The nucleotide and amino acid sequences of this strain were compared with those of the parent strain V4(QUE). There are 16 nucleotide substitutions on V4(UPM), eight of which are silent mutations and another eliminated a potential Asn‐linked glycosylation site in V4(UPM). In addition, an Arg (403) residue was shown to be absent in the variant strain. This deletion is thought to be significant because of its location in a highly conserved region of the HN protein. |
| first_indexed | 2025-11-15T09:58:20Z |
| format | Article |
| id | upm-42345 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-15T09:58:20Z |
| publishDate | 1996 |
| publisher | Houghton Trust |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-423452024-08-05T06:16:14Z http://psasir.upm.edu.my/id/eprint/42345/ Sequence of the haemagglutinin-neuraminidase gene of the Newcastle disease virus oral vaccine strain V4(UPM) Yusoff, Khatijah Tan, Wen Siang Lau, Chin Hoon Ng, Ban Kim Ibrahim, Abdul Latif The nucleotide sequence of the haemagglutinin‐neuraminidase (HN) glycoprotein gene of Newcastle disease virus (NDV) variant strain V4(UPM) was determined by direct genomic RNA sequencing and confirmed by cycle sequencing. The gene comprises 1996 nucleotides encoding a 615 amino acid protein of size 67.4 kDa. The nucleotide and amino acid sequences of this strain were compared with those of the parent strain V4(QUE). There are 16 nucleotide substitutions on V4(UPM), eight of which are silent mutations and another eliminated a potential Asn‐linked glycosylation site in V4(UPM). In addition, an Arg (403) residue was shown to be absent in the variant strain. This deletion is thought to be significant because of its location in a highly conserved region of the HN protein. Houghton Trust 1996 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/42345/1/Sequence%20of%20the%20haemagglutinin-neuraminidase%20gene%20of%20the%20Newcastle%20disease%20virus%20oral%20vaccine%20strain%20V4%28UPM%29.pdf text en http://psasir.upm.edu.my/id/eprint/42345/7/Sequence%20of%20the%20haemagglutinin%20neuraminidase%20gene%20of%20the%20Newcastle%20disease%20virus%20oral%20vaccine%20strain%20V4%20UPM%20.pdf Yusoff, Khatijah and Tan, Wen Siang and Lau, Chin Hoon and Ng, Ban Kim and Ibrahim, Abdul Latif (1996) Sequence of the haemagglutinin-neuraminidase gene of the Newcastle disease virus oral vaccine strain V4(UPM). Avian Pathology, 25 (4). pp. 837-844. ISSN 0307-9457; ESSN: 1465-3338 http://www.tandfonline.com/doi/abs/10.1080/03079459608419185 10.1080/03079459608419185 |
| spellingShingle | Yusoff, Khatijah Tan, Wen Siang Lau, Chin Hoon Ng, Ban Kim Ibrahim, Abdul Latif Sequence of the haemagglutinin-neuraminidase gene of the Newcastle disease virus oral vaccine strain V4(UPM) |
| title | Sequence of the haemagglutinin-neuraminidase gene of the Newcastle disease virus oral vaccine strain V4(UPM) |
| title_full | Sequence of the haemagglutinin-neuraminidase gene of the Newcastle disease virus oral vaccine strain V4(UPM) |
| title_fullStr | Sequence of the haemagglutinin-neuraminidase gene of the Newcastle disease virus oral vaccine strain V4(UPM) |
| title_full_unstemmed | Sequence of the haemagglutinin-neuraminidase gene of the Newcastle disease virus oral vaccine strain V4(UPM) |
| title_short | Sequence of the haemagglutinin-neuraminidase gene of the Newcastle disease virus oral vaccine strain V4(UPM) |
| title_sort | sequence of the haemagglutinin-neuraminidase gene of the newcastle disease virus oral vaccine strain v4(upm) |
| url | http://psasir.upm.edu.my/id/eprint/42345/ http://psasir.upm.edu.my/id/eprint/42345/ http://psasir.upm.edu.my/id/eprint/42345/ http://psasir.upm.edu.my/id/eprint/42345/1/Sequence%20of%20the%20haemagglutinin-neuraminidase%20gene%20of%20the%20Newcastle%20disease%20virus%20oral%20vaccine%20strain%20V4%28UPM%29.pdf http://psasir.upm.edu.my/id/eprint/42345/7/Sequence%20of%20the%20haemagglutinin%20neuraminidase%20gene%20of%20the%20Newcastle%20disease%20virus%20oral%20vaccine%20strain%20V4%20UPM%20.pdf |