Involvement of splenic dendritic cells during infectious bursal disease virus infection in chickens
Infectious bursal disease virus (IBDV) is attracted to lymphoid cells and especially those of B-lymphocyte origins. Recent studies have shown that IBDV also can infect macrophage. However, the involvement of dendritic cells (DC) in IBDV infection is not clear. The objective of this study was to exam...
| Main Authors: | , , , , |
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| Format: | Conference or Workshop Item |
| Language: | English |
| Published: |
Faculty of Veterinary Medicine
2013
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| Online Access: | http://psasir.upm.edu.my/id/eprint/41426/ http://psasir.upm.edu.my/id/eprint/41426/1/41426.pdf |
| _version_ | 1848849691993702400 |
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| author | Abd Rahman, Yasmin Bejo, Mohd Hair Kaiser, Pete Fakurazi, Sharida Omar, Abdul Rahman |
| author_facet | Abd Rahman, Yasmin Bejo, Mohd Hair Kaiser, Pete Fakurazi, Sharida Omar, Abdul Rahman |
| author_sort | Abd Rahman, Yasmin |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Infectious bursal disease virus (IBDV) is attracted to lymphoid cells and especially those of B-lymphocyte origins. Recent studies have shown that IBDV also can infect macrophage. However, the involvement of dendritic cells (DC) in IBDV infection is not clear. The objective of this study was to examine the effect IBDV vaccine and very virulent (vv) strains on avian derived splenic DC. Enriched DCs were cultured from spleen of infected SPF chickens with vaccine and vvIBDV strains of IBDV. The infected DCs were analysed for morphology study, immunophenotyping, proliferation activity, and immunofluorescent antibody test (IFAT). Both IBDV strains inhibit DC proliferation. However, the inhibition is higher in vvIBDV strain group. However, the expressions of IBDV antigens from both strains were detected in splenic DC. |
| first_indexed | 2025-11-15T09:54:26Z |
| format | Conference or Workshop Item |
| id | upm-41426 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T09:54:26Z |
| publishDate | 2013 |
| publisher | Faculty of Veterinary Medicine |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-414262016-01-28T02:06:08Z http://psasir.upm.edu.my/id/eprint/41426/ Involvement of splenic dendritic cells during infectious bursal disease virus infection in chickens Abd Rahman, Yasmin Bejo, Mohd Hair Kaiser, Pete Fakurazi, Sharida Omar, Abdul Rahman Infectious bursal disease virus (IBDV) is attracted to lymphoid cells and especially those of B-lymphocyte origins. Recent studies have shown that IBDV also can infect macrophage. However, the involvement of dendritic cells (DC) in IBDV infection is not clear. The objective of this study was to examine the effect IBDV vaccine and very virulent (vv) strains on avian derived splenic DC. Enriched DCs were cultured from spleen of infected SPF chickens with vaccine and vvIBDV strains of IBDV. The infected DCs were analysed for morphology study, immunophenotyping, proliferation activity, and immunofluorescent antibody test (IFAT). Both IBDV strains inhibit DC proliferation. However, the inhibition is higher in vvIBDV strain group. However, the expressions of IBDV antigens from both strains were detected in splenic DC. Faculty of Veterinary Medicine 2013 Conference or Workshop Item PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/41426/1/41426.pdf Abd Rahman, Yasmin and Bejo, Mohd Hair and Kaiser, Pete and Fakurazi, Sharida and Omar, Abdul Rahman (2013) Involvement of splenic dendritic cells during infectious bursal disease virus infection in chickens. In: World’s Poultry Science Association (Malaysia Branch) and World Veterinary Poultry Association (Malaysia Branch) Scientific Conference 2013, 30 Nov.-1 Dec. 2013, Faculty of Veterinary Medicine, Universiti Putra Malaysia. (pp. 128-129). http://www.vet.upm.edu.my/dokumen/90301_proceeding_WPSA_V2_first_second_XX_new_20121013_%281%29.pdf |
| spellingShingle | Abd Rahman, Yasmin Bejo, Mohd Hair Kaiser, Pete Fakurazi, Sharida Omar, Abdul Rahman Involvement of splenic dendritic cells during infectious bursal disease virus infection in chickens |
| title | Involvement of splenic dendritic cells during infectious bursal disease virus infection in chickens
|
| title_full | Involvement of splenic dendritic cells during infectious bursal disease virus infection in chickens
|
| title_fullStr | Involvement of splenic dendritic cells during infectious bursal disease virus infection in chickens
|
| title_full_unstemmed | Involvement of splenic dendritic cells during infectious bursal disease virus infection in chickens
|
| title_short | Involvement of splenic dendritic cells during infectious bursal disease virus infection in chickens
|
| title_sort | involvement of splenic dendritic cells during infectious bursal disease virus infection in chickens |
| url | http://psasir.upm.edu.my/id/eprint/41426/ http://psasir.upm.edu.my/id/eprint/41426/ http://psasir.upm.edu.my/id/eprint/41426/1/41426.pdf |