Subclinical hypothyroidism among patients with depressive disorders
Subclinical hypothyroidism (SHT) is a biochemical diagnosis, defined as an elevated Thyroid Stimulating Hormone (TSH) with normal free thyroxine (FT4). It affects 4-10% of the adult population and is more prevalent in elderly women. Its commonest cause is autoimmune thyroiditis, detected by anti-thy...
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| Format: | Article |
| Language: | English |
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Faculty of Medicine and Health Sciences, Universiti Putra Malaysia
2014
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| Online Access: | http://psasir.upm.edu.my/id/eprint/41424/ http://psasir.upm.edu.my/id/eprint/41424/1/Subclinical%20hypothyroidism%20among%20patients%20with%20depressive%20disorders.pdf |
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| author | Zahari Sham, Siti Yazmin Umar, Nor Aini Hambali, Zarida Razali, Rosdinom Abdul Manaf, Mohd Rizal |
| author_facet | Zahari Sham, Siti Yazmin Umar, Nor Aini Hambali, Zarida Razali, Rosdinom Abdul Manaf, Mohd Rizal |
| author_sort | Zahari Sham, Siti Yazmin |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Subclinical hypothyroidism (SHT) is a biochemical diagnosis, defined as an elevated Thyroid Stimulating Hormone (TSH) with normal free thyroxine (FT4). It affects 4-10% of the adult population and is more prevalent in elderly women. Its commonest cause is autoimmune thyroiditis, detected by anti-thyroid peroxidase antibody (TPO-Ab). About 2-5% of SHT patients progress to overt hypothyroidism annually. The SHT prevalence among depressed patients ranges between 3% and 17%. This study aimed to determine the prevalence of SHT and TPO-Ab positivity among patients diagnosed with depressive disorders. It was a cross-sectional study carried out in the Universiti Kebangsaan Malaysia Medical Centre over a 12 months period. Serum TSH, FT4 and TPO-Ab were measured. Results showed that 82% of depressed patients were euthyroid, 4% had SHT, 11% had subclinical hyperthyroidism and 2% had discordant thyroid function. TPO-Ab positivity among the subjects was 7%, one of whom had SHT. In conclusion, the prevalence of SHT and TPO-Ab positivity in the study population, at 4% and 7%, respectively, were comparable to previous findings. |
| first_indexed | 2025-11-15T09:54:25Z |
| format | Article |
| id | upm-41424 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T09:54:25Z |
| publishDate | 2014 |
| publisher | Faculty of Medicine and Health Sciences, Universiti Putra Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-414242015-12-18T04:23:55Z http://psasir.upm.edu.my/id/eprint/41424/ Subclinical hypothyroidism among patients with depressive disorders Zahari Sham, Siti Yazmin Umar, Nor Aini Hambali, Zarida Razali, Rosdinom Abdul Manaf, Mohd Rizal Subclinical hypothyroidism (SHT) is a biochemical diagnosis, defined as an elevated Thyroid Stimulating Hormone (TSH) with normal free thyroxine (FT4). It affects 4-10% of the adult population and is more prevalent in elderly women. Its commonest cause is autoimmune thyroiditis, detected by anti-thyroid peroxidase antibody (TPO-Ab). About 2-5% of SHT patients progress to overt hypothyroidism annually. The SHT prevalence among depressed patients ranges between 3% and 17%. This study aimed to determine the prevalence of SHT and TPO-Ab positivity among patients diagnosed with depressive disorders. It was a cross-sectional study carried out in the Universiti Kebangsaan Malaysia Medical Centre over a 12 months period. Serum TSH, FT4 and TPO-Ab were measured. Results showed that 82% of depressed patients were euthyroid, 4% had SHT, 11% had subclinical hyperthyroidism and 2% had discordant thyroid function. TPO-Ab positivity among the subjects was 7%, one of whom had SHT. In conclusion, the prevalence of SHT and TPO-Ab positivity in the study population, at 4% and 7%, respectively, were comparable to previous findings. Faculty of Medicine and Health Sciences, Universiti Putra Malaysia 2014-06 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/41424/1/Subclinical%20hypothyroidism%20among%20patients%20with%20depressive%20disorders.pdf Zahari Sham, Siti Yazmin and Umar, Nor Aini and Hambali, Zarida and Razali, Rosdinom and Abdul Manaf, Mohd Rizal (2014) Subclinical hypothyroidism among patients with depressive disorders. Malaysian Journal of Medicine and Health Sciences, 10 (2). pp. 71-78. ISSN 1675-8544 http://www.medic.upm.edu.my/dokumen/FKUSK1_Jurnal_Text_Article_9.pdf |
| spellingShingle | Zahari Sham, Siti Yazmin Umar, Nor Aini Hambali, Zarida Razali, Rosdinom Abdul Manaf, Mohd Rizal Subclinical hypothyroidism among patients with depressive disorders |
| title | Subclinical hypothyroidism among patients with depressive disorders |
| title_full | Subclinical hypothyroidism among patients with depressive disorders |
| title_fullStr | Subclinical hypothyroidism among patients with depressive disorders |
| title_full_unstemmed | Subclinical hypothyroidism among patients with depressive disorders |
| title_short | Subclinical hypothyroidism among patients with depressive disorders |
| title_sort | subclinical hypothyroidism among patients with depressive disorders |
| url | http://psasir.upm.edu.my/id/eprint/41424/ http://psasir.upm.edu.my/id/eprint/41424/ http://psasir.upm.edu.my/id/eprint/41424/1/Subclinical%20hypothyroidism%20among%20patients%20with%20depressive%20disorders.pdf |