Percentage of haemoglobin variants detected during HbA1c analysis in Hospital Kuala Lumpur
HbA1c is an established index of glycaemic control and correlates strongly with risk of chronic diabetic complications. However, the accuracy of HbA1c measurement can be affected by many factors, among which is the presence of haemoglobin (Hb) variants. The aim of the study was to determine the perc...
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| Format: | Article |
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Faculty of Medicine and Health Sciences, Universiti Putra Malaysia
2013
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| Online Access: | http://psasir.upm.edu.my/id/eprint/41363/ http://psasir.upm.edu.my/id/eprint/41363/1/Percentage%20of%20haemoglobin%20variants%20detected%20during%20HbA1c%20analysis%20in%20Hospital%20Kuala%20Lumpur.pdf |
| _version_ | 1848849675268915200 |
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| author | Samsudin, Intan Nureslyna Md Noor, Sabariah Lim, C. R. Wan Salleh, Wan Nor Syafiqah Chen, D. R. Choy, S. Y. Othman, Nor'Ashikin |
| author_facet | Samsudin, Intan Nureslyna Md Noor, Sabariah Lim, C. R. Wan Salleh, Wan Nor Syafiqah Chen, D. R. Choy, S. Y. Othman, Nor'Ashikin |
| author_sort | Samsudin, Intan Nureslyna |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | HbA1c is an established index of glycaemic control and correlates strongly with risk of chronic diabetic complications. However, the accuracy of HbA1c measurement can be affected by many factors, among which is the presence of haemoglobin (Hb) variants. The aim of the study was to determine the percentage of Hb variant detected during HbA1c monitoring in Hospital Kuala Lumpur. The study also analysed non-reportable HbA1c results in the presence of Hb variants. A cross-sectional study using retrospective data of HbA1c results over five months’ period was analysed on Biorad Variant II Turbo, a high performance liquid chromatography (HPLC) assay. The Hb variants were grouped either as HbS, HbC, others (Hb variant apart from HbS or C), and a combination of HbS or C with Others. A total of 11,904 patients were included. Only 2.3% (273) had Hb variants; HbS trait (10.3%), others (89%), and the combination of HbS trait with others (0.7%). No patient with HbC variant or its combination was found. Only 2.2% of those with Hb variant had non-reportable HbA1c. Although the percentage of Hb variants detected during HbA1c analysis and non-reportable HbA1c results were low, their presence should be noted. |
| first_indexed | 2025-11-15T09:54:10Z |
| format | Article |
| id | upm-41363 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T09:54:10Z |
| publishDate | 2013 |
| publisher | Faculty of Medicine and Health Sciences, Universiti Putra Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-413632015-12-18T00:26:15Z http://psasir.upm.edu.my/id/eprint/41363/ Percentage of haemoglobin variants detected during HbA1c analysis in Hospital Kuala Lumpur Samsudin, Intan Nureslyna Md Noor, Sabariah Lim, C. R. Wan Salleh, Wan Nor Syafiqah Chen, D. R. Choy, S. Y. Othman, Nor'Ashikin HbA1c is an established index of glycaemic control and correlates strongly with risk of chronic diabetic complications. However, the accuracy of HbA1c measurement can be affected by many factors, among which is the presence of haemoglobin (Hb) variants. The aim of the study was to determine the percentage of Hb variant detected during HbA1c monitoring in Hospital Kuala Lumpur. The study also analysed non-reportable HbA1c results in the presence of Hb variants. A cross-sectional study using retrospective data of HbA1c results over five months’ period was analysed on Biorad Variant II Turbo, a high performance liquid chromatography (HPLC) assay. The Hb variants were grouped either as HbS, HbC, others (Hb variant apart from HbS or C), and a combination of HbS or C with Others. A total of 11,904 patients were included. Only 2.3% (273) had Hb variants; HbS trait (10.3%), others (89%), and the combination of HbS trait with others (0.7%). No patient with HbC variant or its combination was found. Only 2.2% of those with Hb variant had non-reportable HbA1c. Although the percentage of Hb variants detected during HbA1c analysis and non-reportable HbA1c results were low, their presence should be noted. Faculty of Medicine and Health Sciences, Universiti Putra Malaysia 2013-06 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/41363/1/Percentage%20of%20haemoglobin%20variants%20detected%20during%20HbA1c%20analysis%20in%20Hospital%20Kuala%20Lumpur.pdf Samsudin, Intan Nureslyna and Md Noor, Sabariah and Lim, C. R. and Wan Salleh, Wan Nor Syafiqah and Chen, D. R. and Choy, S. Y. and Othman, Nor'Ashikin (2013) Percentage of haemoglobin variants detected during HbA1c analysis in Hospital Kuala Lumpur. Malaysian Journal of Medicine and Health Sciences, 9 (2). pp. 13-17. ISSN 1675-8544 http://www.medic.upm.edu.my/dokumen/FKUSK1_MJMHS_2013V09N2_OP02.pdf |
| spellingShingle | Samsudin, Intan Nureslyna Md Noor, Sabariah Lim, C. R. Wan Salleh, Wan Nor Syafiqah Chen, D. R. Choy, S. Y. Othman, Nor'Ashikin Percentage of haemoglobin variants detected during HbA1c analysis in Hospital Kuala Lumpur |
| title | Percentage of haemoglobin variants detected during HbA1c analysis in Hospital Kuala Lumpur |
| title_full | Percentage of haemoglobin variants detected during HbA1c analysis in Hospital Kuala Lumpur |
| title_fullStr | Percentage of haemoglobin variants detected during HbA1c analysis in Hospital Kuala Lumpur |
| title_full_unstemmed | Percentage of haemoglobin variants detected during HbA1c analysis in Hospital Kuala Lumpur |
| title_short | Percentage of haemoglobin variants detected during HbA1c analysis in Hospital Kuala Lumpur |
| title_sort | percentage of haemoglobin variants detected during hba1c analysis in hospital kuala lumpur |
| url | http://psasir.upm.edu.my/id/eprint/41363/ http://psasir.upm.edu.my/id/eprint/41363/ http://psasir.upm.edu.my/id/eprint/41363/1/Percentage%20of%20haemoglobin%20variants%20detected%20during%20HbA1c%20analysis%20in%20Hospital%20Kuala%20Lumpur.pdf |