In vitro antiplasmodial properties of selected plants of Sabah
The antiplasmodial activity of the crude extracts of thirty plant species collected from Sabah was evaluated using chloroquine-sensitive strain (D10) and chloroquine-resistant strain (Gombak A) of Plasmodium falciparum. Significant activities were observed for the bark extract of Polyalthia insignis...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Universiti Putra Malaysia Press
2011
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| Online Access: | http://psasir.upm.edu.my/id/eprint/40635/ http://psasir.upm.edu.my/id/eprint/40635/1/97.%20In%20vitro%20antiplasmodial%20properties%20of%20selected%20plants%20of%20Sabah.pdf |
| Summary: | The antiplasmodial activity of the crude extracts of thirty plant species collected from Sabah was evaluated using chloroquine-sensitive strain (D10) and chloroquine-resistant strain (Gombak A) of Plasmodium falciparum. Significant activities were observed for the bark extract of Polyalthia insignis (IC50 3.89 and 11.89 µg/ml against Gombak A and D10, respectively), the leaf extracts of Kopsia dasyrachis (4.62 µg/ml against Gombak A) and Litsea elliptibacea (IC50 8.88 µg/ml against Gombak A), as well as the leaf and bark extracts of Neouvaria acuminatissima (IC50 6.90-10.08 and 0.69 µg/ml against Gombak A and D10, respectively), and the bark extract of Polyalthia microtus (IC50 9.0 and 12.12 µg/ml against Gombak A and D10, respectively). |
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