Adenoviral based gene therapy for cancer in human and animals: a review
Adenovirus vector is the most common used vector in clinical gene therapy. The development of adenovirus from the first generation until the helper-dependent adenovirus vector has greatly reduced toxicity and immunogenicity. The helper-dependent adenovirus can also prolong transgene expression. Tiss...
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| Format: | Article |
| Language: | English |
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Universiti Putra Malaysia Press
2011
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| Online Access: | http://psasir.upm.edu.my/id/eprint/40590/ http://psasir.upm.edu.my/id/eprint/40590/1/%2317%20Pg%20129-140.pdf |
| _version_ | 1848849469519429632 |
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| author | Tan, Seok Shin Allaudin, Zeenathul Nazariah Mohd Lila, Mohd Azmi |
| author_facet | Tan, Seok Shin Allaudin, Zeenathul Nazariah Mohd Lila, Mohd Azmi |
| author_sort | Tan, Seok Shin |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Adenovirus vector is the most common used vector in clinical gene therapy. The development of adenovirus from the first generation until the helper-dependent adenovirus vector has greatly reduced toxicity and immunogenicity. The helper-dependent adenovirus can also prolong transgene expression. Tissue- or disease-specific approach has been used to improve the specificity of adenoviral vector for cancer gene therapy. This review summarizes some adenoviral gene therapy and targeting approaches available for human cancer as well as animal cancer. |
| first_indexed | 2025-11-15T09:50:53Z |
| format | Article |
| id | upm-40590 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T09:50:53Z |
| publishDate | 2011 |
| publisher | Universiti Putra Malaysia Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-405902016-01-05T08:58:31Z http://psasir.upm.edu.my/id/eprint/40590/ Adenoviral based gene therapy for cancer in human and animals: a review Tan, Seok Shin Allaudin, Zeenathul Nazariah Mohd Lila, Mohd Azmi Adenovirus vector is the most common used vector in clinical gene therapy. The development of adenovirus from the first generation until the helper-dependent adenovirus vector has greatly reduced toxicity and immunogenicity. The helper-dependent adenovirus can also prolong transgene expression. Tissue- or disease-specific approach has been used to improve the specificity of adenoviral vector for cancer gene therapy. This review summarizes some adenoviral gene therapy and targeting approaches available for human cancer as well as animal cancer. Universiti Putra Malaysia Press 2011-01 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/40590/1/%2317%20Pg%20129-140.pdf Tan, Seok Shin and Allaudin, Zeenathul Nazariah and Mohd Lila, Mohd Azmi (2011) Adenoviral based gene therapy for cancer in human and animals: a review. Pertanika Journal of Science & Technology, 19 (1). pp. 129-140. ISSN 0128-7680; ESSN: 2231-8526 http://www.pertanika.upm.edu.my/Pertanika%20PAPERS/JST%20Vol.%2019%20%281%29%20Jan.%202011/%2317%20Pg%20129-140.pdf |
| spellingShingle | Tan, Seok Shin Allaudin, Zeenathul Nazariah Mohd Lila, Mohd Azmi Adenoviral based gene therapy for cancer in human and animals: a review |
| title | Adenoviral based gene therapy for cancer in human and animals: a review |
| title_full | Adenoviral based gene therapy for cancer in human and animals: a review |
| title_fullStr | Adenoviral based gene therapy for cancer in human and animals: a review |
| title_full_unstemmed | Adenoviral based gene therapy for cancer in human and animals: a review |
| title_short | Adenoviral based gene therapy for cancer in human and animals: a review |
| title_sort | adenoviral based gene therapy for cancer in human and animals: a review |
| url | http://psasir.upm.edu.my/id/eprint/40590/ http://psasir.upm.edu.my/id/eprint/40590/ http://psasir.upm.edu.my/id/eprint/40590/1/%2317%20Pg%20129-140.pdf |