Antioxidant and antitumor promoting activities of the flavonoids from Hedychium thyrsiforme
Five flavonoids, including 3,7,4′-trimethoxy-5-hydroxyflavone (1), 3,4′-dimethoxy-5,7-dihydroxyflavone (2), 5,7,4′-trimethoxy-3-hydroxyflavone (3), 3,5,7,4′-tetramethoxyflavone (4), and 7,4′-dimethoxy-3,5-dihydroxyflavone (5), were isolated from the rhizome of Hedychium thyrsiforme and assayed for a...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English English |
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Taylor & Francis
2003
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| Online Access: | http://psasir.upm.edu.my/id/eprint/40438/ http://psasir.upm.edu.my/id/eprint/40438/1/Antioxidant%20and%20antitumor%20promoting%20activities%20of%20the%20flavonoids%20from%20Hedychium%20thyrsiforme.pdf http://psasir.upm.edu.my/id/eprint/40438/7/Antioxidant%20and%20Antitumor%20Promoting%20Activities%20of%20the%20Flavonoids%20from%20Hedychium%20thyrsiforme.pdf |
| _version_ | 1848849425572560896 |
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| author | Karim, Jasril Lim, Yang Mooi Lajis, Nordin Ali, Abdul Manaf Sukari, Mohd Aspollah Rahman, A. A. Othman, A. G. Kikuzaki, Hiroe Nakatani, Nobuji |
| author_facet | Karim, Jasril Lim, Yang Mooi Lajis, Nordin Ali, Abdul Manaf Sukari, Mohd Aspollah Rahman, A. A. Othman, A. G. Kikuzaki, Hiroe Nakatani, Nobuji |
| author_sort | Karim, Jasril |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Five flavonoids, including 3,7,4′-trimethoxy-5-hydroxyflavone (1), 3,4′-dimethoxy-5,7-dihydroxyflavone (2), 5,7,4′-trimethoxy-3-hydroxyflavone (3), 3,5,7,4′-tetramethoxyflavone (4), and 7,4′-dimethoxy-3,5-dihydroxyflavone (5), were isolated from the rhizome of Hedychium thyrsiforme and assayed for antioxidant and antitumor promoting activities. The antioxidant assays showed that 5,7,4′-trimethoxy-3-hydroxyflavone, 7,4′-dimethoxy-3,5-dihydroxyflavone and 3,4′-dimethoxy-5,7-dihydroxyflavone had strong activities. Only two compounds, 5,7,4′-trimethoxy-3-hychoxyflavone and 7,4′-dimethoxy-3,5-dihydroxyflavone, were found to be strong 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavengers with fifty percent inhibition concentration (IC50) values of 92 and 119 μM, respectively. Antitumor promoting assays indicated that all the flavonoids showed strong inhibition activity towards Epstein-Barr virus (EBV) activation in Raji cells. |
| first_indexed | 2025-11-15T09:50:11Z |
| format | Article |
| id | upm-40438 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-15T09:50:11Z |
| publishDate | 2003 |
| publisher | Taylor & Francis |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-404382024-08-06T03:12:25Z http://psasir.upm.edu.my/id/eprint/40438/ Antioxidant and antitumor promoting activities of the flavonoids from Hedychium thyrsiforme Karim, Jasril Lim, Yang Mooi Lajis, Nordin Ali, Abdul Manaf Sukari, Mohd Aspollah Rahman, A. A. Othman, A. G. Kikuzaki, Hiroe Nakatani, Nobuji Five flavonoids, including 3,7,4′-trimethoxy-5-hydroxyflavone (1), 3,4′-dimethoxy-5,7-dihydroxyflavone (2), 5,7,4′-trimethoxy-3-hydroxyflavone (3), 3,5,7,4′-tetramethoxyflavone (4), and 7,4′-dimethoxy-3,5-dihydroxyflavone (5), were isolated from the rhizome of Hedychium thyrsiforme and assayed for antioxidant and antitumor promoting activities. The antioxidant assays showed that 5,7,4′-trimethoxy-3-hydroxyflavone, 7,4′-dimethoxy-3,5-dihydroxyflavone and 3,4′-dimethoxy-5,7-dihydroxyflavone had strong activities. Only two compounds, 5,7,4′-trimethoxy-3-hychoxyflavone and 7,4′-dimethoxy-3,5-dihydroxyflavone, were found to be strong 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavengers with fifty percent inhibition concentration (IC50) values of 92 and 119 μM, respectively. Antitumor promoting assays indicated that all the flavonoids showed strong inhibition activity towards Epstein-Barr virus (EBV) activation in Raji cells. Taylor & Francis 2003 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/40438/1/Antioxidant%20and%20antitumor%20promoting%20activities%20of%20the%20flavonoids%20from%20Hedychium%20thyrsiforme.pdf text en http://psasir.upm.edu.my/id/eprint/40438/7/Antioxidant%20and%20Antitumor%20Promoting%20Activities%20of%20the%20Flavonoids%20from%20Hedychium%20thyrsiforme.pdf Karim, Jasril and Lim, Yang Mooi and Lajis, Nordin and Ali, Abdul Manaf and Sukari, Mohd Aspollah and Rahman, A. A. and Othman, A. G. and Kikuzaki, Hiroe and Nakatani, Nobuji (2003) Antioxidant and antitumor promoting activities of the flavonoids from Hedychium thyrsiforme. Pharmaceutical Biology, 41 (7). pp. 506-511. ISSN 1388-0209; ESSN: 1744-5116 http://www.tandfonline.com/doi/abs/10.1080/13880200308951344 10.1080/13880200308951344 |
| spellingShingle | Karim, Jasril Lim, Yang Mooi Lajis, Nordin Ali, Abdul Manaf Sukari, Mohd Aspollah Rahman, A. A. Othman, A. G. Kikuzaki, Hiroe Nakatani, Nobuji Antioxidant and antitumor promoting activities of the flavonoids from Hedychium thyrsiforme |
| title | Antioxidant and antitumor promoting activities of the flavonoids from Hedychium thyrsiforme |
| title_full | Antioxidant and antitumor promoting activities of the flavonoids from Hedychium thyrsiforme |
| title_fullStr | Antioxidant and antitumor promoting activities of the flavonoids from Hedychium thyrsiforme |
| title_full_unstemmed | Antioxidant and antitumor promoting activities of the flavonoids from Hedychium thyrsiforme |
| title_short | Antioxidant and antitumor promoting activities of the flavonoids from Hedychium thyrsiforme |
| title_sort | antioxidant and antitumor promoting activities of the flavonoids from hedychium thyrsiforme |
| url | http://psasir.upm.edu.my/id/eprint/40438/ http://psasir.upm.edu.my/id/eprint/40438/ http://psasir.upm.edu.my/id/eprint/40438/ http://psasir.upm.edu.my/id/eprint/40438/1/Antioxidant%20and%20antitumor%20promoting%20activities%20of%20the%20flavonoids%20from%20Hedychium%20thyrsiforme.pdf http://psasir.upm.edu.my/id/eprint/40438/7/Antioxidant%20and%20Antitumor%20Promoting%20Activities%20of%20the%20Flavonoids%20from%20Hedychium%20thyrsiforme.pdf |