Mitochondrial mutation in Iranian patients with multiple sclerosis, correlation between haplogroups H, A and clinical manifestations
As multiple sclerosis (MS) has long been known to be associated with Leber, hereditary optic neuropathy (LHON), a disease caused by mitochondrial (mtDNA) mutations, in this study we assessed possible involvement of mtDNA point mutation in MS patients. Fifty-two MS patients whose disease was confirme...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Springer
2009
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| Online Access: | http://psasir.upm.edu.my/id/eprint/40430/ http://psasir.upm.edu.my/id/eprint/40430/1/Mitochondrial%20mutation%20in%20iranian%20patients%20with%20multiple%20sclerosis%2C%20correlation%20between%20haplogroups%20H%2C%20A%20and%20clinical%20manifestations.pdf |
| _version_ | 1848849423163981824 |
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| author | Ghabaee, Mojdeh Omranisikaroudi, Motahar Amrisaroukolaei, Shahla Meysamie, Alipasha Sahraian, Mohammad Ali Bayati, Asghar Sanati, Mohammad Hossein Houshman, Mossoud Sadeghian, Homa Vajihazaman, Khalili |
| author_facet | Ghabaee, Mojdeh Omranisikaroudi, Motahar Amrisaroukolaei, Shahla Meysamie, Alipasha Sahraian, Mohammad Ali Bayati, Asghar Sanati, Mohammad Hossein Houshman, Mossoud Sadeghian, Homa Vajihazaman, Khalili |
| author_sort | Ghabaee, Mojdeh |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | As multiple sclerosis (MS) has long been known to be associated with Leber, hereditary optic neuropathy (LHON), a disease caused by mitochondrial (mtDNA) mutations, in this study we assessed possible involvement of mtDNA point mutation in MS patients. Fifty-two MS patients whose disease was confirmed with revised McDonald criteria and referred to Iranian Center of Neurological Research of Imam Khomeini hospital during 2006–2007 entered the study. Secondary mtDNA mutations, age, gender, clinical disability according to expanded disability status scale (EDSS), course of the disease, and presenting symptoms were the variables investigated in this study. DNA purification was performed by Diatom DNA Extraction Kit. Analysis of data was done by SPSS V11.5. The prevalent mutations with frequency of 19.2% were J, L, and T haplogroups. Haplotype A was more prevalent in patients with younger age of onset (P-value = 0.012) and high proportion of haplogroup H was associated with optic nerve involvement (P-value = 0.015). No motor symptoms were seen in haplogroup H patients. There is no significant relationship between duration of the disease and EDSS in different mutation of mtDNA. |
| first_indexed | 2025-11-15T09:50:09Z |
| format | Article |
| id | upm-40430 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T09:50:09Z |
| publishDate | 2009 |
| publisher | Springer |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-404302015-09-18T02:48:30Z http://psasir.upm.edu.my/id/eprint/40430/ Mitochondrial mutation in Iranian patients with multiple sclerosis, correlation between haplogroups H, A and clinical manifestations Ghabaee, Mojdeh Omranisikaroudi, Motahar Amrisaroukolaei, Shahla Meysamie, Alipasha Sahraian, Mohammad Ali Bayati, Asghar Sanati, Mohammad Hossein Houshman, Mossoud Sadeghian, Homa Vajihazaman, Khalili As multiple sclerosis (MS) has long been known to be associated with Leber, hereditary optic neuropathy (LHON), a disease caused by mitochondrial (mtDNA) mutations, in this study we assessed possible involvement of mtDNA point mutation in MS patients. Fifty-two MS patients whose disease was confirmed with revised McDonald criteria and referred to Iranian Center of Neurological Research of Imam Khomeini hospital during 2006–2007 entered the study. Secondary mtDNA mutations, age, gender, clinical disability according to expanded disability status scale (EDSS), course of the disease, and presenting symptoms were the variables investigated in this study. DNA purification was performed by Diatom DNA Extraction Kit. Analysis of data was done by SPSS V11.5. The prevalent mutations with frequency of 19.2% were J, L, and T haplogroups. Haplotype A was more prevalent in patients with younger age of onset (P-value = 0.012) and high proportion of haplogroup H was associated with optic nerve involvement (P-value = 0.015). No motor symptoms were seen in haplogroup H patients. There is no significant relationship between duration of the disease and EDSS in different mutation of mtDNA. Springer 2009 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/40430/1/Mitochondrial%20mutation%20in%20iranian%20patients%20with%20multiple%20sclerosis%2C%20correlation%20between%20haplogroups%20H%2C%20A%20and%20clinical%20manifestations.pdf Ghabaee, Mojdeh and Omranisikaroudi, Motahar and Amrisaroukolaei, Shahla and Meysamie, Alipasha and Sahraian, Mohammad Ali and Bayati, Asghar and Sanati, Mohammad Hossein and Houshman, Mossoud and Sadeghian, Homa and Vajihazaman, Khalili (2009) Mitochondrial mutation in Iranian patients with multiple sclerosis, correlation between haplogroups H, A and clinical manifestations. Cellular and Molecular Neurobiology, 29 (3). pp. 341-346. ISSN 0272-4340; ESSN: 1573-6830 http://link.springer.com/article/10.1007%2Fs10571-008-9325-7 10.1007/s10571-008-9325-7 |
| spellingShingle | Ghabaee, Mojdeh Omranisikaroudi, Motahar Amrisaroukolaei, Shahla Meysamie, Alipasha Sahraian, Mohammad Ali Bayati, Asghar Sanati, Mohammad Hossein Houshman, Mossoud Sadeghian, Homa Vajihazaman, Khalili Mitochondrial mutation in Iranian patients with multiple sclerosis, correlation between haplogroups H, A and clinical manifestations |
| title | Mitochondrial mutation in Iranian patients with multiple sclerosis, correlation between haplogroups H, A and clinical manifestations |
| title_full | Mitochondrial mutation in Iranian patients with multiple sclerosis, correlation between haplogroups H, A and clinical manifestations |
| title_fullStr | Mitochondrial mutation in Iranian patients with multiple sclerosis, correlation between haplogroups H, A and clinical manifestations |
| title_full_unstemmed | Mitochondrial mutation in Iranian patients with multiple sclerosis, correlation between haplogroups H, A and clinical manifestations |
| title_short | Mitochondrial mutation in Iranian patients with multiple sclerosis, correlation between haplogroups H, A and clinical manifestations |
| title_sort | mitochondrial mutation in iranian patients with multiple sclerosis, correlation between haplogroups h, a and clinical manifestations |
| url | http://psasir.upm.edu.my/id/eprint/40430/ http://psasir.upm.edu.my/id/eprint/40430/ http://psasir.upm.edu.my/id/eprint/40430/ http://psasir.upm.edu.my/id/eprint/40430/1/Mitochondrial%20mutation%20in%20iranian%20patients%20with%20multiple%20sclerosis%2C%20correlation%20between%20haplogroups%20H%2C%20A%20and%20clinical%20manifestations.pdf |