Effects of copper overload on hepatic lipid peroxidation and antioxidant defense in rats
The influence of copper (Cu) overload on hepatic lipid peroxidation and antioxidation defense capacity was studied by overloading rats with copper sulphate orally (500 mg Cu/kg bw) 5 d/w for 8 w. Malondialdehyde (MDA), Cu-Zn superoxide dismutase (SOD), and Se-glutathione peroxidase (GSH-Px) were mea...
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| Format: | Article |
| Language: | English |
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American College of Veterinary Toxicologists
2000
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| Online Access: | http://psasir.upm.edu.my/id/eprint/40378/ http://psasir.upm.edu.my/id/eprint/40378/1/Effects%20of%20copper%20overload%20on%20hepatic%20lipid%20peroxidation%20and%20antioxidant%20defense%20in%20rats.pdf |
| _version_ | 1848849408469237760 |
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| author | Zhang, S. S. Mohamed Mustapha, Noordin Rahman, Shakilur O. A. Haron, Md. Jelas |
| author_facet | Zhang, S. S. Mohamed Mustapha, Noordin Rahman, Shakilur O. A. Haron, Md. Jelas |
| author_sort | Zhang, S. S. |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | The influence of copper (Cu) overload on hepatic lipid peroxidation and antioxidation defense capacity was studied by overloading rats with copper sulphate orally (500 mg Cu/kg bw) 5 d/w for 8 w. Malondialdehyde (MDA), Cu-Zn superoxide dismutase (SOD), and Se-glutathione peroxidase (GSH-Px) were measured in serum and liver homogenate at 2, 4 and 8 w of dosing. Liver Cu concentration and alanine aminotransferase (ALT) activity were also determined. As Cu loading progressed, there were multiparameter changes with significant ALT elevation, increased MDA concentrations in serum and liver homogenate, and dramatic declines of SOD and GSH-Px activities in erythrocytes and whole blood respectively, along with marked elevation of hepatic Cu in the Cu-dosed group. Excessive Cu accumulation in the liver depressed SOD and GSH-Px activities and resulted in high MDA in serum and liver homogenate due to the lipid peroxidation induced by the Cu overload. |
| first_indexed | 2025-11-15T09:49:55Z |
| format | Article |
| id | upm-40378 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T09:49:55Z |
| publishDate | 2000 |
| publisher | American College of Veterinary Toxicologists |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-403782016-11-21T07:10:39Z http://psasir.upm.edu.my/id/eprint/40378/ Effects of copper overload on hepatic lipid peroxidation and antioxidant defense in rats Zhang, S. S. Mohamed Mustapha, Noordin Rahman, Shakilur O. A. Haron, Md. Jelas The influence of copper (Cu) overload on hepatic lipid peroxidation and antioxidation defense capacity was studied by overloading rats with copper sulphate orally (500 mg Cu/kg bw) 5 d/w for 8 w. Malondialdehyde (MDA), Cu-Zn superoxide dismutase (SOD), and Se-glutathione peroxidase (GSH-Px) were measured in serum and liver homogenate at 2, 4 and 8 w of dosing. Liver Cu concentration and alanine aminotransferase (ALT) activity were also determined. As Cu loading progressed, there were multiparameter changes with significant ALT elevation, increased MDA concentrations in serum and liver homogenate, and dramatic declines of SOD and GSH-Px activities in erythrocytes and whole blood respectively, along with marked elevation of hepatic Cu in the Cu-dosed group. Excessive Cu accumulation in the liver depressed SOD and GSH-Px activities and resulted in high MDA in serum and liver homogenate due to the lipid peroxidation induced by the Cu overload. American College of Veterinary Toxicologists 2000 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/40378/1/Effects%20of%20copper%20overload%20on%20hepatic%20lipid%20peroxidation%20and%20antioxidant%20defense%20in%20rats.pdf Zhang, S. S. and Mohamed Mustapha, Noordin and Rahman, Shakilur O. A. and Haron, Md. Jelas (2000) Effects of copper overload on hepatic lipid peroxidation and antioxidant defense in rats. Veterinary and Human Toxicology, 42 (5). pp. 261-264. ISSN 0145-6296 |
| spellingShingle | Zhang, S. S. Mohamed Mustapha, Noordin Rahman, Shakilur O. A. Haron, Md. Jelas Effects of copper overload on hepatic lipid peroxidation and antioxidant defense in rats |
| title | Effects of copper overload on hepatic lipid peroxidation and antioxidant defense in rats |
| title_full | Effects of copper overload on hepatic lipid peroxidation and antioxidant defense in rats |
| title_fullStr | Effects of copper overload on hepatic lipid peroxidation and antioxidant defense in rats |
| title_full_unstemmed | Effects of copper overload on hepatic lipid peroxidation and antioxidant defense in rats |
| title_short | Effects of copper overload on hepatic lipid peroxidation and antioxidant defense in rats |
| title_sort | effects of copper overload on hepatic lipid peroxidation and antioxidant defense in rats |
| url | http://psasir.upm.edu.my/id/eprint/40378/ http://psasir.upm.edu.my/id/eprint/40378/1/Effects%20of%20copper%20overload%20on%20hepatic%20lipid%20peroxidation%20and%20antioxidant%20defense%20in%20rats.pdf |