Antimicrobial, antioxidant, antitumour-promoting and cytotoxic activities of different plant part extracts of Garcinia atroviridis Griff. ex T. Anders
Crude extracts (methanol) of various parts, viz. the leaves, fruits, roots, stem and trunk bark, of Garcinia atroviridis were screened for antimicrobial, cytotoxic, brine shrimp toxic, antitumour-promoting and antioxidant activities. The crude extracts exhibited predominantly antibacterial activity...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English English |
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Elsevier
2000
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| Online Access: | http://psasir.upm.edu.my/id/eprint/40314/ http://psasir.upm.edu.my/id/eprint/40314/1/Antimicrobial%2C%20antioxidant%2C%20antitumour-promoting%20and%20cytotoxic%20activities%20of%20different%20plant%20part%20extracts%20of%20Garcinia%20atroviridis%20Griff.%20ex%20T.%20Anders.pdf http://psasir.upm.edu.my/id/eprint/40314/7/1-s2.0-S0378874100002452-main.pdf |
| _version_ | 1848849390700068864 |
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| author | Mohamed Mackeen, Muhammad Mukram Ali, Abdul Manaf Lajis, Nordin Kawazu, Kazuyoshi Hassan, Zaiton Amran, Mugahed Mohamad, Habsah Mooi, Lim Yang Mohamed, S. M. |
| author_facet | Mohamed Mackeen, Muhammad Mukram Ali, Abdul Manaf Lajis, Nordin Kawazu, Kazuyoshi Hassan, Zaiton Amran, Mugahed Mohamad, Habsah Mooi, Lim Yang Mohamed, S. M. |
| author_sort | Mohamed Mackeen, Muhammad Mukram |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Crude extracts (methanol) of various parts, viz. the leaves, fruits, roots, stem and trunk bark, of Garcinia atroviridis were screened for antimicrobial, cytotoxic, brine shrimp toxic, antitumour-promoting and antioxidant activities. The crude extracts exhibited predominantly antibacterial activity with the root extract showing the strongest inhibition against the test bacteria at a minimum inhibitory dose (MID) of 15.6 μg/disc. Although all the extracts failed to inhibit the growth of most of the test fungi, significant antifungal activity against Cladosporium herbarum was exhibited by most notably the fruit (MID: 100 μg), and the leaf (MID: 400 μg) extracts. None of the extracts were significantly cytotoxic, and lethal towards brine shrimps. The root, leaf, trunk and stem bark extracts (except for the fruits) showed strong antioxidant activity exceeding that of the standard antioxidant, α-tocopherol. Antitumour-promoting activity (>95% inhibition) was shown by the fruit, leaf, stem and trunk bark extracts. |
| first_indexed | 2025-11-15T09:49:38Z |
| format | Article |
| id | upm-40314 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-15T09:49:38Z |
| publishDate | 2000 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-403142024-07-23T00:14:24Z http://psasir.upm.edu.my/id/eprint/40314/ Antimicrobial, antioxidant, antitumour-promoting and cytotoxic activities of different plant part extracts of Garcinia atroviridis Griff. ex T. Anders Mohamed Mackeen, Muhammad Mukram Ali, Abdul Manaf Lajis, Nordin Kawazu, Kazuyoshi Hassan, Zaiton Amran, Mugahed Mohamad, Habsah Mooi, Lim Yang Mohamed, S. M. Crude extracts (methanol) of various parts, viz. the leaves, fruits, roots, stem and trunk bark, of Garcinia atroviridis were screened for antimicrobial, cytotoxic, brine shrimp toxic, antitumour-promoting and antioxidant activities. The crude extracts exhibited predominantly antibacterial activity with the root extract showing the strongest inhibition against the test bacteria at a minimum inhibitory dose (MID) of 15.6 μg/disc. Although all the extracts failed to inhibit the growth of most of the test fungi, significant antifungal activity against Cladosporium herbarum was exhibited by most notably the fruit (MID: 100 μg), and the leaf (MID: 400 μg) extracts. None of the extracts were significantly cytotoxic, and lethal towards brine shrimps. The root, leaf, trunk and stem bark extracts (except for the fruits) showed strong antioxidant activity exceeding that of the standard antioxidant, α-tocopherol. Antitumour-promoting activity (>95% inhibition) was shown by the fruit, leaf, stem and trunk bark extracts. Elsevier 2000-10 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/40314/1/Antimicrobial%2C%20antioxidant%2C%20antitumour-promoting%20and%20cytotoxic%20activities%20of%20different%20plant%20part%20extracts%20of%20Garcinia%20atroviridis%20Griff.%20ex%20T.%20Anders.pdf text en http://psasir.upm.edu.my/id/eprint/40314/7/1-s2.0-S0378874100002452-main.pdf Mohamed Mackeen, Muhammad Mukram and Ali, Abdul Manaf and Lajis, Nordin and Kawazu, Kazuyoshi and Hassan, Zaiton and Amran, Mugahed and Mohamad, Habsah and Mooi, Lim Yang and Mohamed, S. M. (2000) Antimicrobial, antioxidant, antitumour-promoting and cytotoxic activities of different plant part extracts of Garcinia atroviridis Griff. ex T. Anders. Journal of Ethnopharmacology, 72 (3). pp. 395-402. ISSN 0378-8741; ESSN: 1872-7573 http://www.sciencedirect.com/science/article/pii/S0378874100002452 10.1016/S0378-8741(00)00245-2 |
| spellingShingle | Mohamed Mackeen, Muhammad Mukram Ali, Abdul Manaf Lajis, Nordin Kawazu, Kazuyoshi Hassan, Zaiton Amran, Mugahed Mohamad, Habsah Mooi, Lim Yang Mohamed, S. M. Antimicrobial, antioxidant, antitumour-promoting and cytotoxic activities of different plant part extracts of Garcinia atroviridis Griff. ex T. Anders |
| title | Antimicrobial, antioxidant, antitumour-promoting and cytotoxic activities of different plant part extracts of Garcinia atroviridis Griff. ex T. Anders |
| title_full | Antimicrobial, antioxidant, antitumour-promoting and cytotoxic activities of different plant part extracts of Garcinia atroviridis Griff. ex T. Anders |
| title_fullStr | Antimicrobial, antioxidant, antitumour-promoting and cytotoxic activities of different plant part extracts of Garcinia atroviridis Griff. ex T. Anders |
| title_full_unstemmed | Antimicrobial, antioxidant, antitumour-promoting and cytotoxic activities of different plant part extracts of Garcinia atroviridis Griff. ex T. Anders |
| title_short | Antimicrobial, antioxidant, antitumour-promoting and cytotoxic activities of different plant part extracts of Garcinia atroviridis Griff. ex T. Anders |
| title_sort | antimicrobial, antioxidant, antitumour-promoting and cytotoxic activities of different plant part extracts of garcinia atroviridis griff. ex t. anders |
| url | http://psasir.upm.edu.my/id/eprint/40314/ http://psasir.upm.edu.my/id/eprint/40314/ http://psasir.upm.edu.my/id/eprint/40314/ http://psasir.upm.edu.my/id/eprint/40314/1/Antimicrobial%2C%20antioxidant%2C%20antitumour-promoting%20and%20cytotoxic%20activities%20of%20different%20plant%20part%20extracts%20of%20Garcinia%20atroviridis%20Griff.%20ex%20T.%20Anders.pdf http://psasir.upm.edu.my/id/eprint/40314/7/1-s2.0-S0378874100002452-main.pdf |